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Catalytic asymmetric transfer hydrogenation of rac-furoin and furil produces hydrofuroin with up to 99% ee and 9:1 dr. This reaction provides an exceptionally easy access to optically active hydrofuroins in two straightforward steps from biomass-derived furfural (global production 200,000-300,000 t annually) using benzoin condensation.
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http://dx.doi.org/10.1021/ol3018402 | DOI Listing |
Angew Chem Int Ed Engl
September 2025
Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing, 210042, China.
Developing the efficient C─H bond activation carboxylation processes for furoic acid (FA) represents a critical technological challenge in achieving atom-economical synthesis of 2,5-furandicarboxylic acid (FDCA). Despite notable advancements in this field, the inherent contradiction between the high reactivity of furan rings and the chemical inertness of C─H bonds poses substantial technical bottleneck for achieving controllable C─H carboxylation under mild conditions. Herein, we report a high lattice-distorted MnOx catalyst with surface trench-like structures, wherein the Mn-O-conjugated configurations and electron-rich Mn cooperatively drive FA dehydrogenation and carbon radical reduction, inducing the free radical evolution process (FA→carbon-centered FA radical→FA carbanion), then coupled with solvent-polarized CO to accelerate the carboxylation process.
View Article and Find Full Text PDFRSC Adv
September 2025
Department of Chemical Engineering and Green Technology, Institute of Chemical Technology (ICT) Mumbai Maharashtra 400019 India
The sustainable synthesis of bio-based monomers from renewable biomass intermediates is a central goal in green chemistry and biorefinery innovation. This study introduces a synergistic catalytic-enzymatic strategy for the efficient and eco-friendly oxidation of 5-hydroxymethylfurfural (5-HMF) into 2,5-furandicarboxylic acid (FDCA), a key monomer for next-generation biodegradable plastics. The catalytic phase employed non-noble metal catalysts, MnO and Co-Mn supported on activated carbon (Co-Mn/AC), under mild batch reaction conditions at 90 °C.
View Article and Find Full Text PDFJ Colloid Interface Sci
September 2025
Faculty of Chemical Engineering, Kunming University of Science and Technology, Kunming 650093, China.
Encapsulation of non-noble bimetallic nanoparticles within a zeolite framework can improve the stability and accessibility of active sites, but the single microporous structure and poor metal stability decreased the catalytic performance of the catalyst. Here, 3D hierarchical ZSM-5 zeolite encapsulated NiCo nanoparticles (NiCo@3DHZ5) were synthesized by Bottom-up confined steam-assisted crystallization (SAC) one-pot hydrothermal method and applied to the hydrodeoxygenation of vanillin. A series of characterizations showed that highly stable alloyed NiCo nanoparticles were encapsulated in a framework of 3DHZ5, the strong metal-zeolite interactions resulted in highly dispersed NiCo nano-alloys facilitated hydrogen adsorption and spillover of active hydrogen atoms, and the 3D hierarchical structure promoted oxygenated substrate diffusion, the synergy interaction between the alloy particles confined in the 3DHZ5 pores and the acidic sites on the zeolite surface promoted the selective conversion of vanillin.
View Article and Find Full Text PDFAnnu Rev Microbiol
September 2025
3Department of Biology, Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Plant biomass has emerged as a cornerstone of the global bioenergy landscape because of its abundance and cost-effectiveness. The cell wall of plant biomass is an intricate network of cellulose, hemicellulose, and lignin. The hydrolysis of cellulose and hemicellulose by holoenzymes converts these polymers into monosaccharides and paves the way for the production of bioethanol and other bio-based products.
View Article and Find Full Text PDFChem Biodivers
September 2025
Key Lab of Natural Product Chemistry and Application at Universities of Education, Department of Xinjiang Uygur Autonomous Region, School of Chemistry and Chemical Engineering, Yili Normal University, Xinjiang, China.
The persistent threat posed by phytopathogenic fungi to agricultural systems underscores the critical need for novel fungicides. Here, we synthesized and characterized a series of novel acridospiroisoxazole derivatives (H1-H36) using H/C NMR and mass spectrometry. The absolute configuration of compound H23 was confirmed using single-crystal x-ray diffraction analysis.
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