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Optimal gingival contours around restored teeth and implants are of critical importance for restorative success and esthetics. This paper describes a novel computer-aided methodology for building a 3-D statistical model of gingival contours from a 3-D scan dental dataset and reconstructing missing gingival contours in partially edentulous patients. The gingival boundaries were first obtained from the 3-D dental model through a discrete curvature analysis and shortest path searching algorithm. Based on the gingival shape differential characteristics, the boundaries were demarcated to construct the gingival contour of each individual tooth. Through B-spline curve approximation to each gingival contour, the control points of the B-spline curves are used as the shape vector for training the model. Statistical analysis results demonstrate that the method can give a simple but compact model that effectively capture the most important variations in arch width and shape as well as gingival morphology and position. Within this statistical model, the morphologically plausible missing contours can be inferred based on a nonlinear optimization fitting from the global similarity transformation, the model shape deformation and a Mahalanobis prior. The reconstruction performance is evaluated through large simulated experimental data and a real patient case, which demonstrates the effectiveness of this approach.
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http://dx.doi.org/10.1109/TBME.2012.2183368 | DOI Listing |
J Voice
September 2025
Bielefeld University, P.O. Box 10 01 31, Bielefeld D-33501, Germany. Electronic address:
To this day, the assessment of human voices remains a challenge due to (i) inconsistencies in subjective ratings and (ii) the lack of objective measurements for the perceptual impressions of voice characteristics. This can lead to significant consequences in applied fields such as speech therapy, where the assessment of voices is crucial for a successful treatment. In this paper, we address the explanation of voice and its characteristics from two different angles: In a first study, 22 speech therapists in training assessed a set of 20 non-pathological voices regarding 20 voice characteristics before and after receiving an expert explanation.
View Article and Find Full Text PDFNeurosci Biobehav Rev
September 2025
Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia.
This systematic review was conducted to provide a comprehensive summary of biopsychosocial factors associated with attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with Neurofibromatosis Type 1 (NF1), and identify key limitations and gaps in the current literature. Systematic literature searches were conducted in Scopus, PsycINFO, Web of Science, PubMed, and ProQuest Dissertations and Theses Global in March 2024. The searches identified 2,345 unique articles.
View Article and Find Full Text PDFTransplant Cell Ther
September 2025
Department of Medical Imaging, Hematology and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Background: Hepatic sinusoidal obstruction syndrome (SOS), or veno-occlusive disease (VOD), is a severe complication following hematopoietic stem cell transplantation (HSCT), often leading to liver dysfunction and poor outcomes if not detected early. Traditional diagnostic methods, including ultrasound and liver biopsy, have limitations in sensitivity and feasibility. Non-invasive elastography techniques, such as transient elastography (TE) and shear-wave elastography (SWE), offer a promising alternative by quantitatively assessing liver stiffness.
View Article and Find Full Text PDFJ Dent
September 2025
Dental Clinic Post-Graduate Program, University Center of State of Pará, Belém, Pará, Brazil. Electronic address:
Objective: This study evaluated the coherence, consistency, and diagnostic accuracy of eight AI-based chatbots in clinical scenarios related to dental implants.
Methods: A double-blind, clinical experimental study was carried out between February and March 2025, to evaluate eight AI-based chatbots using six fictional cases simulating peri-implant mucositis and peri-implantitis. Each chatbot answered five standardized clinical questions across three independent runs per case, generating 720 binary outputs.
Cell Rep Methods
August 2025
Interdepartmental Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT 06511, USA; Department of Biostatistics, Yale University, New Haven, CT 06511, USA. Electronic address:
Single-cell multi-modal data integration has been an area of active research in recent years. However, it is difficult to unify the integration process of different omics in a pipeline and evaluate the contributions of data integration. In this article, we revisit the definition and contributions of multi-modal data integration and propose a strong and scalable method based on probabilistic deep learning with an explainable framework powered by statistical modeling to extract meaningful information after data integration.
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