Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
This systematic review was conducted to provide a comprehensive summary of biopsychosocial factors associated with attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with Neurofibromatosis Type 1 (NF1), and identify key limitations and gaps in the current literature. Systematic literature searches were conducted in Scopus, PsycINFO, Web of Science, PubMed, and ProQuest Dissertations and Theses Global in March 2024. The searches identified 2,345 unique articles. Two researchers independently screened articles and extracted data. Inclusion criteria were met by 68 articles. We synthesized results across studies in a narrative format, following the Guidance on the Conduct of Narrative Synthesis in Systematic Reviews. Based on the biopsychosocial model of mental health, we grouped study findings on factors associated with ADHD into broad categories of biological (n = 33), psychological (n = 47), and social factors (n = 13), which were further divided into subcategories. Findings varied across biopsychosocial factors, ADHD-related variables (inattention, hyperactivity, impulsivity symptoms, or ADHD diagnosis), measurement methods, study designs, and statistical approaches. Psychological factors (e.g., executive functioning, IQ) were most commonly studied. Findings revealed consistent evidence for the link between informant-reported executive functioning problems and ADHD, whereas performance-based cognitive measures generally showed no significant associations. Most studies are cross-sectional and have small and nonrepresentative samples. Methodological limitations in previous studies hinder definitive conclusions on biopsychosocial factors associated with ADHD in NF1. Future research should use larger samples and longitudinal or experimental designs, explore understudied biological and social factors, and incorporate new technologies to improve understanding and interventions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neubiorev.2025.106355 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An International Classification of Functioning, Disability, and Health (ICF) comprehensive core set for vertebral fragility fracture.
Disabil Rehabil
September 2025
Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Purpose: To develop a comprehensive ICF Core Set (ICF-CS) for vertebral fragility fracture.
Materials And Methods: The development of ICF-CSs involves three phases: i) systematic literature review and qualitative studies; ii) linking process to identify the ICF codes and categories; iii) international consensus process. i) We performed a literature search and qualitative studies with people with vertebral fragility fractures and healthcare professionals; ii) We linked the findings from the search and qualitative studies to the ICF categories, and drafted the proposed ICF-CS; iii) We performed an international consensus process involving experts with clinical or research experience in management of vertebral fragility fractures.
Objectives: Azapirone-class drugs are partial 5-HT1A receptor agonists commonly used to treat anxiety disorders. Prior experimental studies have so far demonstrated that these drugs have low potential for dependence and problematic use and are considered safe treatment options compared with benzodiazepines. However, recent evidence suggesting the contrary raises concerns about their safety.
View Article and Find Full Text PDFDelphi Assessment of Home-Based Digital Healthcare for Aging Patients: A Biopsychosocial Perspective.
Clin Interv Aging
September 2025
Gravitational Physiology and Medicine Research Unit, Division of Physiology and Pathophysiology, Otto Löwi Research Center of Vascular Biology, Immunity and Inflammation, Medical University of Graz, Graz, Austria.
Purpose: The development of home-based clinical interventions and healthcare supported by digital tools has rapidly advanced in recent years, promising improvements in preventive and personalized treatment, especially for aging chronic patients. However, many systems are launched without feedback from healthcare experts, essential for understanding their strengths, limitations, and areas for improvement. This study had two objectives: first, to gather expert opinions on the qualities and limitations of current home-centred healthcare trends for aging patients; second, as a case study, to obtain feedback on a novel system, (TI-Health), integrating these trends.
View Article and Find Full Text PDFSystematic Review: Biopsychosocial Factors Related to Attention-Deficit/Hyperactivity Disorder in Children/Adolescents with Neurofibromatosis Type 1.
Neurosci Biobehav Rev
September 2025
Murdoch Children's Research Institute, Melbourne, Australia; Department of Pediatrics, University of Melbourne, Melbourne, Australia.
This systematic review was conducted to provide a comprehensive summary of biopsychosocial factors associated with attention-deficit/hyperactivity disorder (ADHD) in children and adolescents with Neurofibromatosis Type 1 (NF1), and identify key limitations and gaps in the current literature. Systematic literature searches were conducted in Scopus, PsycINFO, Web of Science, PubMed, and ProQuest Dissertations and Theses Global in March 2024. The searches identified 2,345 unique articles.
View Article and Find Full Text PDFBiopsychosocial and Environmental Factors that Impact Brain-Gut-Microbiome Interactions in Obesity.
Clin Gastroenterol Hepatol
August 2025
Vatche and Tamar Manoukian Division of Digestive Diseases, University of California, Los Angeles; Goodman Luskin Microbiome Center, University of California, Los Angeles; G. Oppenheimer Center for Neurobiology of Stress and Resilience, University of California, Los Angeles; David Geffen School of Me
Background: Despite significant advances in the understanding of the pathogenesis of obesity and influencing factors, its prevalence continues to increase at an alarming rate. Social determinants of health (SDOH) encompass a broad range of psychosocial and environmental factors, including economic stability, education, access to healthcare, social support, isolation, neighborhood disadvantage, discrimination, early life adversity, and stress, all of which have been recognized to significantly increase the risk of obesity.
Aim: This review aims to elucidate the intricate relationship between SDOH and biological mechanisms related to the brain-gut-microbiome (BGM) system that lead to altered eating behaviors and obesity.