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Objective: Adherence to clinical guidelines for mental disorders among clinicians in industrialized countries is low. Research on guideline adherence among clinicians in lower- and middle-income countries is scarce. The purpose of this study was to evaluate the implementation of clinical guidelines for first-episode schizophrenia in the pilot phase of the Explicit Guarantees in Health (GES) program in Chile.
Methods: Data were collected from 12 catchment areas in Chile, representing 58% of the public health system. Records for 20 patients from each site who were referred to the GES program with a tentative diagnosis of first-episode schizophrenia were reviewed. Adherence to first- and second-line antipsychotic treatments, use of diagnostic measures, and psychosocial interventions recommended in the guidelines were evaluated.
Results: In the final sample of 110 patients, adherence to medication guidelines was good-86% received the recommended first-line antipsychotic. Psychoeducation was provided to 55% of patients and 49% of their families, but other psychosocial interventions were used more rarely. Use of symptom rating scales was low. At 12 months, 19% of patients had dropped out of treatment.
Conclusions: Adherence to treatment guidelines in the Chilean GES program was remarkably good for pharmacological treatment, average for psychosocial interventions, and low for utilization of symptom scales and diagnostic measures. The dropout rate was low.
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http://dx.doi.org/10.1176/appi.ps.001042011 | DOI Listing |
Comput Methods Programs Biomed
September 2025
Department of Medical Imaging and Radiation Sciences, School of Primary and Allied Health Care, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia. Electronic address:
Background And Purpose: Several studies have shown changes in neurochemicals within the deep-brain nuclei of patients with psychosis. These alterations indicate a dysfunction in dopamine within subcortical regions affected by fluctuations in iron concentrations. Quantitative Susceptibility Mapping (QSM) is a method employed to measure iron concentration, offering a potential means to identify dopamine dysfunction in these subcortical areas.
View Article and Find Full Text PDFBehav Modif
September 2025
University of California, Los Angeles, USA.
We examined the effects of combining cognitive training plus aerobic exercise versus cognitive training alone on positive symptoms in recent-onset schizophrenia patients. Sixty-eight participants were randomly assigned to Cognitive Training plus Exercise (CT&E, = 37) or Cognitive Training alone (CT, = 31). All participants were also randomly assigned to either oral risperidone or paliperidone palmitate (PP1M) in a concurrent antipsychotic medication study.
View Article and Find Full Text PDFAlpha Psychiatry
August 2025
The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, 610036 Chengdu, Sichuan, China.
Objective: Physical aggression in schizophrenia patients carries significant societal implications. Previous studies on aggression prediction have primarily focused on hospitalized patients, overlooking specific rural community contexts in China. This study investigated multidimensional predictive factors to develop and validate a predictive model for predicting physical aggression in schizophrenia patients in rural communities in southwestern China.
View Article and Find Full Text PDFAlpha Psychiatry
August 2025
Department of Clinical Laboratory, Beijing Huilongguan Hospital, 100096 Beijing, China.
Objective: To analyze the correlation between interleukin-5 (IL-5), eosinophils (EOS), and immunoglobulin A (IgA) levels with schizophrenia, and assess their potential as auxiliary diagnostic markers for schizophrenia.
Methods: This study comprised 57 patients with first-episode schizophrenia and 340 patients with recurrent or chronic schizophrenia who were hospitalized at Beijing Huilongguan Hospital from March 2023 to August 2024, and 72 healthy volunteers were recruited as the control group. Fasting venous blood samples were collected from all participants on the second day after admission.
Schizophr Res
September 2025
UHC Sestre Milosrdnice, Department of Psychiatry, Zagreb, Croatia; Catholic University of Croatia, School of Medicine, Zagreb, Croatia.
Objective: Thalamic abnormalities have been associated with clinical and cognitive symptoms of schizophrenia, yet their role in the early stages of the disorder remain unclear. This study aimed to examine and compare thalamic perfusion differences between first-episode schizophrenia (FES) and early-course schizophrenia (ECS), along with their associations with cognitive performance and symptom severity.
Methods: This study included 100 unmedicated schizophrenia patients aged 19-30: 50 FES and 50 ECS (<5 years, ≥2 episodes).