Effects of pH on potassium: new explanations for old observations.

J Am Soc Nephrol

Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8029, USA.

Published: November 2011


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Article Abstract

Maintenance of extracellular K(+) concentration within a narrow range is vital for numerous cell functions, particularly electrical excitability of heart and muscle. Potassium homeostasis during intermittent ingestion of K(+) involves rapid redistribution of K(+) into the intracellular space to minimize increases in extracellular K(+) concentration, and ultimate elimination of the K(+) load by renal excretion. Recent years have seen great progress in identifying the transporters and channels involved in renal and extrarenal K(+) homeostasis. Here we apply these advances in molecular physiology to understand how acid-base disturbances affect serum potassium.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3231780PMC
http://dx.doi.org/10.1681/ASN.2011040414DOI Listing

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