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This review deals with general and significant development of the fluorous organocatalysts based on thiourea. The applications of fluorous technology are briefly discussed. The implementations of thiourea based catalysts in organic synthesis are focused on in the chapter.
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http://dx.doi.org/10.1007/128_2011_248 | DOI Listing |
Colloids Surf B Biointerfaces
September 2025
Department of Analytical Chemistry, College of Chemistry, Jilin University, Changchun 130012, China. Electronic address:
Herein, a novel S/N co-doped carbon-based nanozyme (S/N-Fe) with peroxidase-like properties was synthesized by doping thiourea into Fe MOF and introducing g-CN for pyrolysis. Generated by enzymatic cascade with acetylcholinesterase (AChE) involved, HO could react with S/N-Fe to generate reactive oxygen species (ROS). O-Phenylenediamine (OPD) could be catalyzed by ROS, resulting in the production of 2,3-diaminophenazine (DAP) with a fluorescent emission at 564 nm.
View Article and Find Full Text PDFACS Omega
August 2025
VinUni-Illinois Smart Health Center, VinUniversity, Hanoi 100000, Vietnam.
Accurate and accessible glucose detection is essential for clinical diagnostics, point-of-care testing, food safety, and biosensing applications. In this study, we present a simple, scalable, and dual-mode glucose sensor that integrates commercial potassium permanganate (KMnO) with glucose oxidase to enable sensitive and selective detection in the clinically critical range of 1-5 mM. Leveraging the strong oxidative power and distinct optical characteristics of KMnO, the sensor operates via both absorbance measurement at 400 nm and visual colorimetric analysis, displaying a clear color change from purple to pink and yellow upon reaction with glucose.
View Article and Find Full Text PDFJ Chromatogr A
August 2025
Nuclear and Chemical Sciences Division, Lawrence Livermore National Laboratory, Livermore, California 94550, United States.
Radioactive arsenic (As) isotopes are of growing interest for applications in nuclear medicine, national security, and environmental research. Recent efforts at the Facility for Rare Isotope Beams (FRIB) have focused on aqueous harvesting of selenium-72,73 (Se) and their daughter isotopes, arsenic-72,73 (As), which are particularly valuable for medical applications and nuclear data studies, respectively. Both conventional isotope production and harvesting methods require chemical separations to purify radioactive As from parent and co-produced Se radioisotopes.
View Article and Find Full Text PDFMolecules
August 2025
Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, Departamento de Química Inorgánica, Pedro Cerbuna 12, 50009 Zaragoza, Spain.
Pyridyl-thiourea complexes of formula [(Cym)MCl(κ,-)][SbF] (Cym = --MeCHPr; = -(-tolyl)--(2-pyridylmethyl)thiourea); M = Ru (), Os ()) were synthesized by reacting the corresponding metal dimers [{(Cym)MCl}(-Cl)] with in the presence of NaSbF. Subsequent chloride abstraction with AgSbF, followed by NH deprotonation using NaHCO, afforded the cationic complexes [(Cym)M(κ,,)][SbF] (M = Ru (), (); M = Os ()) and [(Cym)M(κ,)][SbF] (M = Ru (); M = Os ()). The proposed structures for the prepared compounds are based on NMR data.
View Article and Find Full Text PDFBioorg Chem
August 2025
Dipartimento di Chimica 'Ugo Schiff', Università degli Studi di Firenze, via della Lastruccia 3-13, Sesto Fiorentino, FI 50019, Italy. Electronic address:
The so-called "sugar approach" in the field of human Carbonic Anhydrase (hCA) inhibition is the installation of a hydrophilic sugar moiety in the tail of a sulfonamide derivative to induce selectivity towards the different isoforms. Further investigations on our related "azasugar approach" variant, where the sugar is replaced by a polyhydroxypiperidine with a basic nitrogen atom, are reported. The synthesis and biological evaluation of a series of benzenesulfonamides, urea-, thiourea-, or amide-analogues of previously assessed inhibitors but lacking the triazole ring in the connecting chain to the azasugar, has allowed to draw some hints, albeit the precise effects on inhibition of a given hCA isoform needs to be evaluated case by case.
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