98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jdermsci.2011.06.014 | DOI Listing |
Clin Rheumatol
September 2025
Immunology Market Access, Johnson & Johnson, Horsham, PA, USA.
Introduction/objective: Oral glucocorticoids (OGC) are conventionally used as first-line treatment for dermatomyositis (DM) and polymyositis (PM). This study evaluated clinical and economic outcomes associated with long-term (LT) OGC use in DM/PM.
Methods: Adults with ≥ 2 medical claims of DM/PM 30‒365 days apart from January 1, 2016, to December 31, 2022, and ≥ 1 diagnosis code of a physician specialty of interest were selected from the MarketScan Commercial and Medicare Supplemental databases.
J Mol Histol
September 2025
Department of Urology, Yantai Yuhuangding Hospital, Qingdao University, No. 20 East Yuhuangding Road, Yantai, 264000, Shandong, China.
The stress urinary incontinence (SUI) is a difficulty in urology and current sub-urethral sling treatments are associated with inflamation and recurrence. In this study, we developed a novel tissue-engineered sling with myogenic induced adiposederived stem cells (MI-ADSCs) sheets induced by 5-Aza and combined with electrospun scaffolds of silk fibroin and poly(lactide-co-glycolide) (SF/PLGA) for the treatment of stress urinary incontinence. MI-ADSCs increased α-SMA, MyoD and Desmin the mRNA and protein expression.
View Article and Find Full Text PDFAesthetic Plast Surg
September 2025
Department of Surgical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Hangzhou, 310016, Zhejiang, China.
J Neurosci
September 2025
Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030, United States.
Presenilin mutations are the most common cause of familial Alzheimer's disease (FAD), but the mechanisms by which they disrupt neuronal function remain unresolved, particularly in relation to γ-secretase activity. Using , we show that the presenilin ortholog SEL-12 supports synaptic transmission and axonal integrity through a pathway involving the ryanodine receptor RYR-1. Loss-of-function mutations in either or reduce neurotransmitter release and cause neuronal structural defects, with no additional impairment in double mutants, suggesting a shared pathway.
View Article and Find Full Text PDFTalanta
September 2025
Warsaw University of Technology, Faculty of Chemistry, Chair of Analytical Chemistry, Noakowskiego St. 3, 00-664, Warsaw, Poland. Electronic address:
The contamination of agricultural soils with military-grade explosives such as 2,4,6-trinitrotoluene (TNT), 1,3,5-trinitro-1,3,5-triazaccyclohexane (RDX) and 1,3,5,7-tetranitro-1,3,5,7-tetraazacyclohexane (HMX) is an emerging concern in post-conflict regions, where food crops may take up these compounds. This study presents a novel analytical approach for detecting explosive residues in wheat (Triticum aestivum L.) grown on contaminated substrates.
View Article and Find Full Text PDF