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Article Abstract
Aim: To observe the expressional alterations of colony stimulating factor-1 receptor (CSF-1R) after ischemic injury of cerebral cortex, and study the function of colony stimulating factor-1 (CSF-1)/CSF-1R signal during the process of ischemic injury and repair of central nervous system (CNS).
Methods: We examined the distribution and expression of CSF-1R in normal brain tissues and ischemic brain tissues by immunohistology and Western blot analysis.
Results: The expression of CSF-1R in neurons could be up-regulated by ischemic injury in CNS.
Conclusion: CSF-1/CSF-1R might take part in the process of ischemic injury and repair.
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