Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1001/jama.2010.1057 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Conserved Cia1-Cia2 Interface Mediates Client Recruitment in the Cytosolic Iron-Sulfur Cluster Assembly Pathway.
J Am Chem Soc
September 2025
Department of Chemistry, Boston University, 590 Commonwealth Ave, Boston, Massachusetts 02215, United States.
The cytosolic iron-sulfur cluster assembly (CIA) targeting complex maturates over 30 cytosolic and nuclear Fe-S proteins, raising the question of how a single complex recognizes such a diverse set of clients. The discovery of a C-terminal targeting complex recognition (TCR) peptide in up to 25% of CIA clients provided a clue to substrate specificity, yet the molecular and energetic basis for this interaction remained unresolved. By integrating computational and biochemical approaches, we show that the TCR peptide binds a conserved interface between the Cia1 and Cia2 subunits of the targeting complex, even in the absence of the Fe-S cluster.
View Article and Find Full Text PDFKnockdown of UBD Ameliorates Experimental Rheumatoid Arthritis by Suppressing TLR4/Myd88/NF-κB and P38/MAPK Pathway.
Cell Physiol Biochem
September 2025
Department of General Practice, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China, E-Mail:
Background/aims: Ubiquitin D (UBD), a member of the ubiquitin-like modifier (UBL) family, is significantly overexpressed in various cancers and is positively correlated with tumor progression. However, the role and underlying mechanisms of UBD in rheumatoid arthritis (RA) remain poorly understood. This study aimed to investigate the effects of UBD knockdown on the progression of RA.
View Article and Find Full Text PDFInhibition of WAC alleviates the chondrocyte proinflammatory secretory phenotype and cartilage degradation H2BK120ub1 and H3K27me3 coregulation.
Acta Pharm Sin B
August 2025
Department of Orthopedics, the Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518003, China.
Several types of arthritis share the common feature that the generation of inflammatory mediators leads to joint cartilage degradation. However, the shared mechanism is largely unknown. H2BK120ub1 was reportedly involved in various inflammatory diseases but its role in the shared mechanism in inflammatory joint conditions remains elusive.
View Article and Find Full Text PDFImpact of multi-strain probiotics supplementation on growth, immune responses and physiological traits in backyard poultry of Andaman and Nicobar Islands, India.
Front Microbiol
August 2025
Department of Veterinary Pathology, West Bengal University of Animal and Fishery Sciences (W.B.U.A.F.S), Kolkata, India.
Antibiotic growth promoters (AGPs) are widely used as feed additives to enhance the immunity, and productivity in the poultry industries. But over usage of AGPs has led to multi drug-resistance among pathogens. Nonspecific immunomodulators like probiotics have emerged as competent replacements of AGPs.
View Article and Find Full Text PDFFibroblast activation protein-α drives rheumatoid arthritis inflammation through the AKT/mTOR signaling pathway and its therapeutic effect by Wangbi granules.
Phytomedicine
August 2025
National Center for Integrative Medicine, Department of TCM Rheumatism, China-Japan Friendship Hospital, Beijing, China. Electronic address:
Background: Fibroblast activation protein-α (FAPα), a transmembrane protein highly expressed in rheumatoid arthritis (RA) synovium, is postulated to drive inflammatory cascades, yet its mechanistic role remains elusive. Wangbi granules (WBG), a clinically used traditional Chinese medicine (TCM), show anti-RA potential but lack defined pharmacological evidence.
Purpose: To identify FAPα as an inflammatory driver in RA pathogenesis and decipher how WBG suppresses FAPα-mediated AKT/mTOR signaling to resolve inflammation.