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Correlation between cardiovascular magnetic resonance features and clinical characteristics of cardiac involvement in connective tissue diseases.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha 410008.
Objectives: Patients with connective tissue diseases (CTD) have a high incidence of cardiac involvement, which often presents insidiously and can progress rapidly, making it one of the leading causes of death. Multiparametric cardiovascular magnetic resonance (CMR) provides a comprehensive quantitative evaluation of myocardial injury and is emerging as a valuable tool for detecting cardiac involvement in CTD. This study aims to investigate the correlations between CMR features and serological biomarkers in CTD patients, assess their potential clinical value, and further explore the impact of pre-CMR immunotherapy intensity on CMR-specific parameters, thereby evaluating the role of CMR in the early diagnosis of CTD-related cardiac involvement.
View Article and Find Full Text PDFFerric derisomaltose augments intrinsic skeletal muscle electron transport chain activity in heart failure: A FERRIC-HF II molecular substudy.
Eur J Heart Fail
September 2025
School of Cardiovascular & Metabolic Medicine and Science, James Black Centre, King's College London British Heart Foundation Centre of Excellence, London, UK.
Aims: Skeletal muscle energetic augmentation might be a mechanism via which intravenous iron improves symptoms in heart failure, but no direct measurement of intrinsic mitochondrial function has been performed to support this notion. This molecular substudy of the FERRIC-HF II trial tested the hypothesis that ferric derisomaltose (FDI) would improve electron transport chain activity, given its high dependence on iron-sulfur clusters which facilitate electron transfer during oxidative phosphorylation.
Methods And Results: Vastus lateralis skeletal muscle biopsies were taken before and 2 weeks after randomization.
Inducible Ischemia in Asymptomatic Patients With Coronary Chronic Total Occlusions: A Stress CMR Study.
Catheter Cardiovasc Interv
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IRCCS Humanitas Research Hospital, Rozzano-Milan, Italy.
Background: Given the divergence in recommendations regarding the relevance of inducible ischemia regarding the indication to revascularize chronic total occlusions (CTOs) among European and North American guidelines, we aim at investigating the prevalence and the prognostic impact of significant inducible ischemia in an unselected cohort of asymptomatic CTO patients, integrating collateralization status and viability assessment with stress cardiac magnetic resonance (CMR).
Methods: From a cohort of 749 patients referred to our center with a diagnosis of CTO, we retrospectively analyzed 111 asymptomatic individuals who underwent an adenosine stress CMR. The amount of inducible ischemia subtended by the CTO was calculated, as well as the presence of viable myocardium and the collateralization status.
Value of CMR-derived Quantitative Myocardial Blood Flow Assessment in The Setting of Chronic Coronary Occlusion.
Eur Heart J Cardiovasc Imaging
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Bosch Health Campus, Robert Bosch Hospital, Department of Cardiology and Angiology, Stuttgart, Germany.
Aims: For many years, visual assessment has been the mainstay of detecting obstructive coronary artery disease (CAD) by stress perfusion cardiovascular magnetic resonance (S-CMR). Recently, fully automated quantitative assessment of myocardial blood flow (MBF) has been introduced. The value of MBF quantification in patients with coronary chronic total occlusion (CTO) is unknown.
View Article and Find Full Text PDFMPTN: A video-based multi-point tracking network for atrioventricular junction detection and tracking in cardiovascular magnetic resonance imaging.
Comput Methods Programs Biomed
August 2025
CardioVascular Systems Imaging and Artificial Intelligence Lab, National Heart Centre Singapore, Singapore; Duke-NUS Medical School, Singapore; Department of Biomedical Engineering, National University of Singapore, Singapore. Electronic address:
Background And Objective: To develop an end-to-end artificial intelligence solution-video-based Multi-Point Tracking Network (MPTN), for detecting and tracking atrioventricular junction (AVJ) points from cardiovascular magnetic resonance and deriving AVJ motion parameters.
Methods: The MPTN model consists of two modules: AVJ point detection and AVJ motion tracking. The detection module utilizes convolutional-based feature extraction and elastic regression to detect all candidate AVJ points.