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http://dx.doi.org/10.1007/978-1-4419-5692-7_27 | DOI Listing |
Pompe disease (PD) is a rare, autosomal recessive neuromuscular disorder caused by a deficiency in acid α-glucosidase. In the Phase 3 COMET trial (NCT02782741), respiratory function was examined in participants with late-onset PD randomized to receive enzyme replacement therapy with alglucosidase alfa (ALG; standard of care) or avalglucosidase alfa (AVA; intervention) in the primary analysis period (PAP). The open-label extended treatment period (ETP) provided long-term data on AVA treatment.
View Article and Find Full Text PDFPhysiother Theory Pract
July 2025
Faculty of Medicine, Department of Pulmonology, Gazi University, Ankara, Türkiye.
Background: Pulmonary involvement due to coronavirus disease 2019 (COVID-19) is common. Pulmonary involvement may affect pulmonary function. Moreover, structural alterations in the lungs may impair the extrapulmonary functions.
View Article and Find Full Text PDFBMC Pulm Med
May 2025
Department of Respiratory Care, Chang Gung University of Science and Technology, Chiayi, 613, Taiwan.
Background: Previous studies have demonstrated the positive effects of long-term inspiratory muscle training (IMT) on inspiratory muscle strength and pulmonary function. However, the benefits of IMT with aerobic exercise (IMT + AE) in patients with myasthenia gravis (MG) remain unclear. This randomized controlled trial aimed to assess the impact of the early, 6-week, moderate-intensity interval IMT + AE on pulmonary function, functional capacity, and respiratory muscle strength in patients with MG post-hospitalization.
View Article and Find Full Text PDFSupport Care Cancer
April 2025
Faculty of Health Sciences, Division of Physiotherapy and Rehabilitation, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Purpose: This study aimed to compare the effects of manual lymphatic drainage and bandaging (MLDB) combined with calf muscle exercise training (CMT) and/or inspiratory muscle training (IMT) on edema, muscle strength, functional capacity, functionality, and quality of life (QoL) in patients with secondary lower limb lymphedema (LLL).
Method: A total of 76 patients (mean age: 47.06 ± 16.
BMJ Open
March 2025
Centre for Heart Lung Innovation, The University of British Columbia, Vancouver, British Columbia, Canada
Introduction: The rapid growth in popularity of e-cigarettes over the past decade has prompted concerns about their impact on long-term respiratory health. Small airway injury is suspected to be a direct consequence of e-cigarette use and may be quantifiable by novel structural and functional diagnostic modalities.
Methods And Analysis: In a multicentre observational longitudinal study, participants will be enrolled in either an adolescent (ages ≥12 and <19 years) or an adult arm (≥19 years old) and followed over 3 years across three time points (baseline, 18 months and 36 months).