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Feature extraction of event-related potentials (ERP) plays an important part in both basic and clinical researches for cerebral neurophysiology. ICA is a method for separating blind signals based on signal statistic characteristics. In this paper, the fundamental principle, the discrimination condition and the practical algorithm of Independent Component Analysis are discussed. Then, a fast Independent Component Analysis algorithm (Fast ICA) is introduced. But like Fast ICA, its convergence is dependent on initial weight. We bring in a revision factor into the algorithm; thus the new algorithm could implement convergence on a largescale. In this paper, the revision factor is calculated by gradient. By modifying kernel iterate course, several iterations of Fast ICA are merged into one iteration of Modified Fast ICA, so the convergence of ICA will be accelerated. Finally, Modified ICA is applied to ERP extraction. The simulation shows that the convergence speed can be increased by using the improved algorithm.
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Anal Chim Acta
October 2025
Hefei Institute of Physical Science, Chinese Academy of Sciences, Hefei, 230036, China. Electronic address:
Background: The excessive use of pesticide pollutants in agricultural production seriously threatens food safety. Traditional detection techniques are difficult to meet the detection requirements due to the complex sample pretreatment and high detection costs. The immunochromatography method (ICA) is simple to operate and fast, and is suitable for on-site rapid detection.
View Article and Find Full Text PDFCells
August 2025
Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) tend to show a mixed population of action potential (AP) types, including atrial-like (A-like) and ventricular-like (V-like) APs. In the present study, we investigated the membrane currents underlying these two AP types in hESC-CMs. These were generated using standard (Std) and retinoic acid (RA)-based differentiation protocols.
View Article and Find Full Text PDFNeurosurgery
July 2025
Department of Neurosurgery, Emory University, Atlanta, Georgia, USA.
Background And Objectives: Despite successful endovascular thrombectomy for acute ischemic stroke, a significant proportion of patients demonstrate fast and early progression of infarct core and fail to achieve functional independence at 90 days. The aim of this study was to evaluate the impact of thrombus location and the potential impact of collaterals on concurrent middle cerebral artery (MCA) and anterior cerebral artery (ACA) occlusion.
Methods: Data were included from a multicenter registry for patients undergoing endovascular thrombectomy for anterior circulation stroke from 32 international centers between 2015 and 2021.
J Physiol
July 2025
College of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, South Korea.
Changes in heart rate affect Ca signalling and contractility in ventricular muscle, but the effects on atrial Ca signalling are poorly understood. Here, we explored how increased stimulation frequency affects right atrial (RA) and left atrial (LA) local Ca signalling and underlying cellular mechanisms. We used two-dimensional confocal Ca imaging, patch clamping, immunocytochemistry and western blotting in isolated rat atrial myocytes.
View Article and Find Full Text PDFChemistry
June 2025
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee, Uttarakhand, India.
Cesium lead bromide perovskite nanocrystals (NCs) show great potential for photoelectric properties. However, due to their poor stability and the insulating nature of passivating ligands, they suffer from practical applications. Herein, in an approach to passivate the NCs surface by introducing a ligand, Indole-2-carboxylic acid (ICA), we synthesized a mixed CsPbBr/CsPbBr NCs by a ligand-assisted reprecipitation approach.
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