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Front Pharmacol
August 2025
Department of Translational and Clinical Research, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India.
Background: Epilepsy is a chronic and complex brain disorder characterized by frequent seizures, cognitive impairments, neuroinflammation, oxidative stress, and imbalances in neurotransmitters. Developing an effective therapeutic intervention to target these pathological interventions remains a challenge. Trimetazidine (TMZ), the most commonly known anti-ischemic agent, has emerged as a promising candidate for its role in epilepsy due to its diverse mechanisms of action.
View Article and Find Full Text PDFBreast Cancer Res Treat
November 2025
Institute of Health and Wellbeing, Federation University Australia, Ballarat, VIC, Australia.
Purpose: This study aimed to systematically assess the efficacy of cardioprotective agents in preventing anthracycline-induced cardiotoxicity in patients with breast cancer using a comprehensive network meta-analysis (NMA).
Methods: This study included patients with breast cancer undergoing anthracycline-based chemotherapy. Randomized controlled trials (RCTs) published before March 2020 were identified through systematic searches in MEDLINE, Cochrane CENTRAL, Web of Science, and CINAHL.
Bioorg Chem
August 2025
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. Electronic address:
The thalidomide incident has aroused our attention immensely to the structure activity relationship of chiral drugs. BO (Bing-Pian or Long-Nao) ccould be obtained from natural extracts or artificial synthesis. It has four different stereoisomers: (+)-isoborneol, (-)-isoborneol, (+)-borneol, and (-)-borneol.
View Article and Find Full Text PDFCardiooncology
July 2025
State Key Laboratory for Innovation and Transformation of Luobing Theory, Jinan, China.
Introduction: Anthracycline-induced cardiotoxicity is a significant concern for breast cancer patients undergoing treatment, often leading to chronic cardiovascular complications and reduced long-term survival. The study aimed to systematically evaluate the efficacy of nine classes of pharmacological agents in protecting against cardiotoxicity in breast cancer patients treated with anthracyclines.
Methods: A comprehensive search of databases was performed from January 2000 to October 2024 to identify randomized controlled trials (RCTs) investigating cardioprotective agents.
Cardiovasc Res
July 2025
Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, location VUmc, The Netherlands.
Aims: Previous studies have shown that individuals with a hypertrophic cardiomyopathy (HCM) pathogenic variant (PV) or likely pathogenic variant (LPV) without a HCM phenotype (PV/LPV carrier) have decreased myocardial external efficiency (MEE), which is thought to be a key pathomechanism in the onset and progression of HCM. Metabolic treatments improved exercise capacity in HCM patients, but evidence that such drugs correct reduced MEE is lacking. The ENERGY trial is a double-blind, placebo-controlled randomized clinical trial to define if the metabolic drug trimetazidine (TMZ) corrects reduced MEE in PV/LPV carriers for HCM.
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