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Purpose: Detection of amblyopia in infants and toddlers is difficult because the current clinical standard for this age group, fixation preference, is inaccurate. Although grating acuity represents an alternative, studies of preschoolers and schoolchildren report that it is not equivalent to the gold standard optotype acuity. Here, we examine whether the Teller Acuity Cards (TAC) can detect amblyopia effectively by testing children old enough (7.8 +/- 3.6 years) to complete optotype acuity testing.
Methods: Grating acuity was assessed monocularly in 45 patients with unilateral amblyopia, 44 patients at risk for amblyopia, and 37 children with no known vision disorders. Each child's grating acuity was classified as normal/abnormal based on age-appropriate norms. These classifications were compared with formal amblyopia diagnoses.
Results: Grating acuity was finer than optotype acuity among amblyopic eyes (medians: 0.28 vs. 0.40 logMAR, respectively, p < 0.0001) but not among fellow eyes (medians: 0.03 vs. 0.10 logMAR, respectively, p = 0.36). The optotype acuity-grating acuity discrepancy among amblyopic eyes was larger for cases of severe amblyopia than for moderate amblyopia (means: 0.64 vs. 0.18 logMAR, respectively, p = 0.0001). Nevertheless, most cases of amblyopia were detected successfully by the TAC, yielding a sensitivity of 80%. Furthermore, grating acuity was relatively sensitive to all amblyopia subtypes (69 to 89%) and levels of severity (79 to 83%).
Conclusions: Although grating acuity is finer than optotype acuity in amblyopic eyes, most children with amblyopia were identified correctly suggesting that grating acuity is an effective clinical alternative for detecting amblyopia.
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http://dx.doi.org/10.1097/OPX.0b013e3181a523a3 | DOI Listing |
Cogn Neurodyn
December 2025
School of Mathematics, Northwest University, Xi'an, China.
This study sought to enhance visual acuity assessment using steady-state visual evoked potentials (SSVEPs) through subject-specific training methods. SSVEPs were elicited from eleven subjects using the vertical sinusoidal gratings at six various spatial frequency steps, and then the classical approach of Oz single-channel, the spatial filtering method of canonical correlation analysis (CCA), and five subject-specific training methods, i.e.
View Article and Find Full Text PDFDoc Ophthalmol
July 2025
Eye Center, Medical Center, University of Freiburg, Killianstr. 5, 79106, Freiburg, Germany.
Purpose: Objective estimation of visual acuity (VA) based on visual evoked potentials (VEPs) has become an established technique for cases where psychophysical VA might be unreliable. Refractive errors and improper accommodation could undesirably affect the outcome of VA measurements. Consequently, it is of interest whether a VA reduction due to dioptric blur is reflected by VEP-based estimation of VA.
View Article and Find Full Text PDFAm J Drug Alcohol Abuse
July 2025
Department of Medical Biology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey.
Postnatal alcohol exposure impairs the development of the central nervous system, including the visual system. The behavioral consequences of such exposure on visual function remain poorly understood. In this study, we investigated the effects of postnatal ethanol exposure on visuospatial learning and memory in C57BL/6 mice.
View Article and Find Full Text PDFFront Med (Lausanne)
June 2025
Visual Science and Optometry Center, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Objective: This study aimed to investigate the association between spherical equivalent (SE) and interocular suppression in myopic adults, addressing the knowledge gap in functional visual impairments beyond structural changes.
Methods: This hospital-based cross-sectional study included 988 myopic patients (aged 18.0-48.
J Neurosci
June 2025
Center for Visual Science, University of Rochester, Rochester, New York 14642
Damage to retinal cells from disease or injury causes vision loss and remodeling of downstream visual information processing circuits. As retinal cell replacement therapies and prosthetics become increasingly viable, we must understand the postretinal consequences of retinal cell loss to optimally recover visual perception. Here, we asked whether loss of retinal ganglion cells (RGCs) differentially impacts postsynaptic neurons in the visual thalamus-the dorsal lateral geniculate nucleus (LGN)-of ferrets, highly visual carnivores.
View Article and Find Full Text PDF