Stereoacuity and ocular-associated factors in children aged 3-7 years in Guangxi, Southwest China: a cross-sectional study.

Objective: This study aimed to investigate the distribution of stereoacuity and its ocular-associated factors in children aged 3-7 years in Guangxi, Southwest China.

Methods: This cross-sectional study recruited 4,090 children aged 3-7 years (mean: 5.12 ± 0.

The hidden impact of myopia severity on interocular suppression in myopia: a cross-sectional study.

Objective: This study aimed to investigate the association between spherical equivalent (SE) and interocular suppression in myopic adults, addressing the knowledge gap in functional visual impairments beyond structural changes.

Methods: This hospital-based cross-sectional study included 988 myopic patients (aged 18.0-48.

Efficacy and factors influencing toric orthokeratology lenses in managing moderate to high astigmatic myopia.

Significance: Toric orthokeratology lenses show potential in slowing myopia progression in adolescents with moderate to high astigmatic myopia. These findings support the broader application of toric orthokeratology in managing challenging refractive conditions and mitigating myopia-related complications.

Purpose: This study seeks to probe the efficacy of toric orthokeratology lenses in controlling moderate to high astigmatic myopia in adolescents and to analyze the risk factors influencing treatment outcomes.

Increasing myopic refraction reduces random dot stereopsis in Chinese myopic patients: a cross-sectional study.

Objective: To investigate the effects of myopic spherical equivalent (SE) on random dot stereopsis and influencing factors in Chinese adults with myopia.

Methods: A cross-sectional design was employed, and 988 Chinese myopic individuals (520 [52.6%] females) aged 18.

The Modulation of Laser Refractive Surgery on Sensory Eye Dominance of Anisometropia.

Purpose: To evaluate the effect of laser refractive surgery on sensory eye dominance of anisometropia.

Methods: A total of 156 subjects with nonanisometropic myopia and 70 subjects with anisometropic myopia were enrolled in the first part of the study. The dichoptic motion coherence threshold technique was applied to collect the normal dataset and distribution of sensory eye dominance.

Trehalose hydrogels for stabilization of enzymes to heat.

Enzymes can catalyze various reactions with high selectivity and are involved in many important biological processes. However, the general instability of enzymes against high temperature often limits their application. To address this, we synthesized a trehalose-based hydrogel in two steps from commercial starting materials with minimal purification procedures.

Protein-polymer conjugation via ligand affinity and photoactivation of glutathione S-transferase.

A photoactivated, site-selective conjugation of poly(ethylene glycol) (PEG) to the glutathione (GSH) binding pocket of glutathione S-transferase (GST) is described. To achieve this, a GSH analogue (GSH-BP) was designed and chemically synthesized with three functionalities: (1) the binding affinity of GSH to GST, (2) a free thiol for polymer functionalization, and (3) a photoreactive benzophenone (BP) component. Different molecular weights (2 kDa, 5 kDa, and 20 kDa) of GSH-BP modified PEGs (GSBP-PEGs) were synthesized and showed conjugation efficiencies between 52% and 76% to GST.

Therapeutic protein-polymer conjugates: advancing beyond PEGylation.

Protein-polymer conjugates are widely used as therapeutics. All Food and Drug Administration (FDA)-approved protein conjugates are covalently linked to poly(ethylene glycol) (PEG). These PEGylated drugs have longer half-lives in the bloodstream, leading to less frequent dosing, which is a significant advantage for patients.

Morphing hydrogel patterns by thermo-reversible fluorescence switching.

Stimuli responsive surfaces that show reversible fluorescence switching behavior in response to temperature changes were fabricated. Oligo(ethylene glycol) methacrylate thermoresponsive polymers with amine end-groups were prepared by atom transfer radical polymerization (ATRP). The polymers were patterned on silicon surfaces by electron beam (e-beam) lithography, followed by conjugation of self-quenching fluorophores.

Prevalence of high astigmatism in children aged 3 to 6 years in Guangxi, China.

Purpose: To investigate the prevalence and type of high astigmatism among children aged 3 to 6 years in Guangxi, a relatively undeveloped province in western China, and to examine the correlation between astigmatism and visual acuity.

Methods: Children aged 3 to 6 years in Nanning, the capital of Guangxi Province, participated in a population-based survey using a cluster random sampling technique. Eye examinations included autorefraction, visual acuity measurements, and assessments of the external eye, anterior segment, media, and fundus.

Trehalose glycopolymers as excipients for protein stabilization.

Herein, the synthesis of four different trehalose glycopolymers and investigation of their ability to stabilize proteins to heat and lyophilization stress are described. The disaccharide, α,α-trehalose, was modified with a styrenyl acetal, methacrylate acetal, styrenyl ether, or methacrylate moiety resulting in four different monomers. These monomers were then separately polymerized using free radical polymerization with azobisisobutyronitrile (AIBN) as an initiator to synthesize the glycopolymers.

Synthesis of glycopolymers by controlled radical polymerization techniques and their applications.

Natural saccharides are involved in numerous biological processes. It has been shown that these carbohydrates play a role in cell adhesion and proliferation, as well as protein stabilization, organization, and recognition. Certain carbohydrates also serve as receptors for viruses and bacteria.

Design of multivalent galactosyl carborane as a targeting specific agent for potential application to boron neutron capture therapy.

A multivalent galactosyl carborane derivative 10 (dendritic glyco-borane, DGB) was synthesized and demonstrated as a potential cell-targeting agent in BNCT with HepG2 cells. DGB 10 improved the delivery of boron to HepG2 cells and neutron irradiation data show DGB 10 with ten-fold improvement at killing the HepG2 cells over BSH.