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IncA/C plasmids carrying an unusual cassette configuration in a class 1 integron and five further shared resistance genes, aacC4, aphA1, hph, sul2, and tetA(D) were found in Salmonella enterica serovars Senftenberg and Ohio. A deletion formed using a short region of homology in the 5' conserved segment and the orfF cassette created an array with only part of orfF followed by the aadA2 cassette. The IncA/C plasmids were not recoverable by conjugation, but additional conjugative resistance plasmids were present in some strains.
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http://dx.doi.org/10.1128/AAC.00233-09 | DOI Listing |
BMC Microbiol
July 2025
College of Veterinary Medicine, Xinjiang Agricultural University, Urumqi, 830052, China.
Background: Florfenicol is a critical antibiotic used in cattle to manage respiratory infections, while azithromycin is recommended for treating early-stage Shiga toxin-producing Escherichia coli (STEC) infections. This study focused on examining the co-resistance and mechanisms of co-dissemination of resistance to florfenicol and azithromycin in 367 non-O157 STEC strains isolated from cattle in Xinjiang between 2015 and 2023.
Results: Among these isolates, 16.
Microorganisms
April 2025
Centre d'appui pour la Prévention des Infections Associées aux Soins (CPias) Hauts-de-France, Home des Infirmiers, Avenue Oscar Lambret, 59037 Lille, Cedex, France.
Outbreaks involving carbapenemase-producing enterobacteria (CPE) have become a common occurrence in healthcare settings. While clonal dissemination is firmly established as a cause for these outbreaks, horizontal gene transfers (HGTs) between different species of Enterobacterales found in clinical and environmental isolates are less so. To gather evidence backing up this hypothesis, a review covering the 2013-2024 period was performed.
View Article and Find Full Text PDFFront Cell Infect Microbiol
May 2025
Jiangsu Key Laboratory of Zoonosis/Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China.
Salmonellosis, caused by non-typhoidal , is a common foodborne gastrointestinal infection. Third-generation cephalosporins are recommended as the first-line treatment for infections. Our study aimed to investigate the molecular epidemiology, antimicrobial resistance, and the transmission of extended-spectrum β-lactamases (ESBL) genes in 96 clinical isolates collected between 2020 and 2022 at a tertiary hospital in Shenzhen, China.
View Article and Find Full Text PDFJ Glob Antimicrob Resist
May 2025
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal do Rio Grande Do Sul (UFRGS), Porto Alegre, RS, Brazil; Laboratório de Pesquisa em Resistência Bacteriana, Centro de Pesquisa Experimental, Hospital de Clínicas de Porto Alegre (HCPA), Porto Ale
Objective: Infections due to carbapenemase-producing Enterobacterales harbouring more than one carbapenemase-encoding gene spread mainly by plasmid and transposon mobilisation. The objective of this study was to analyse the mobile genetic elements carrying bla and bla of Klebsiella pneumoniae carbapenemase co-producers (KpKN).
Methods: K.
Front Microbiol
February 2025
Avian Disease Research Center, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
-lactam antibiotics are essential medications for treating human diseases. The spread of extended-spectrum β-lactamase-producing (ESBL-PE) exists globally in multiple reservoirs and the natural environment and poses an immense threat to public health. Plasmid incompatibility groups, such as IncFIA, IncI1, IncY, IncFIB, IncN, IncFIC, IncX4, IncB/O/K/Z, IncHI1/2, and IncA/C, which exist in humans, animals, and the environment, carrying , , and genes.
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