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An antiadhesive absorbable means "Mezogel" produced by the firm "Lintex" (St. Petersburg) after intraperitoneal administration to animals in experiments was shown to reliably effectively reduce the degree of a recurrent adhesion process, and in 40% of the cases to completely prevent repeated formation of adhesions in the abdominal cavity. The use of "Mezogel" for intraperitoneal administration after dissection of adhesions in patients with acute adhesive intestinal obstruction results in relieving the course of the nearest and long term postoperative periods and reducing the number of recurrences, thus improving quality of life of the patients.
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ACS Nano
September 2025
Department of Chemistry, Queen Mary University of London, Mile End Road, London E1 4NS, United Kingdom.
Nanoscale organization of integrin-mediated receptor crosstalk is crucial for controlling cellular signaling in cancer biology. Previously, interactions between integrin αvβ6 and receptor tyrosine kinases (RTKs) have been implicated in cancer progression, but the spatial regulatory mechanisms remain undefined. Here, we developed a programmable DNA origami-based platform for nanoscale control of heteroligand multivalency and spacing, enabling systematic investigation of αvβ6-RTK interactions in cancer biology.
View Article and Find Full Text PDFDev Comp Immunol
September 2025
Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA. Electronic address:
Several studies have described immune responses in the teleost brain and meninges during infection, however, fundamental studies that systematically dissect how different regions of the brain maintain immune homeostasis in teleosts are missing. Here we present an in-depth investigation of the immune status of the brain parenchyma and meninges of juvenile rainbow trout (Oncorhynchus mykiss) at the steady state. We dissected four parenchymal brain regions including olfactory bulbs (OB), telencephalon (Tel), optic tectum (OT) and cerebellum (Cer) and its corresponding dorsal meninges.
View Article and Find Full Text PDFJ Hazard Mater
September 2025
State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Environmental Health Risk Assessment Engineering Research Center, Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, N
Nickel exposure elevates aortic dissection (AD) risk, yet its pathogenic mechanisms remain unclear. Here, we demonstrate that nickel accelerates AD progression, particularly in hypertensive individuals. Bioinformatics analysis of GEO datasets identified chemokine-mediated endothelial-neutrophil crosstalk as a key pathway.
View Article and Find Full Text PDFFront Surg
August 2025
Department of General Surgery, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Objective: To summarize the diagnosis and treatment experience of small intestinal duplication malformations in our hospital.
Methods: We retrospectively analyzed data from 90 children undergoing surgery for intestinal duplication malformations at our hospital from October 2019 to October 2024. All patients underwent transumbilical single-site laparoscopic-assisted resection.
MicroPubl Biol
August 2025
Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi, Japan.
Presynaptic active zones (AZs) form during synaptogenesis and are critical for ensuring precise synaptic transmission. Although much is known about the development of AZs at the neuromuscular junction, their assembly in the central nervous system (CNS) remains incompletely understood. Here, we demonstrate the mushroom body α/β Kenyon cells in young adults in which new AZs are continuously formed, as a novel system to dissect the sequential AZ assembly in the CNS.
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