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Recent registry results have shown that polyvascular disease (PolyVD), usually manifested as coronary heart disease or peripheral arterial disease (PAD), is a marker of increased morbidity and mortality in patients with noncardioembolic ischaemic stroke, but is often inadequately assessed. This Personal View Paper advocates routine examination for PolyVD in such patients. Peripheral arterial disease can be readily detected in routine practice by measurement of the ankle-brachial index. This paper makes recommendations for risk stratification, discharge documentation and, where possible, management of ischaemic stroke patients with PolyVD.
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http://dx.doi.org/10.1111/j.1747-4949.2008.00220.x | DOI Listing |
Neurotherapeutics
September 2025
Department of Neurology, Peking University Third Hospital, Beijing, 100191, China; Beijing Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing, 100191, China; Key Laboratory for Neuroscience, National Health Commission/Ministry of Education, Peking Universit
Extensive research has confirmed that omega-3 fatty acids provide cardiovascular protection primarily by activating the G protein-coupled receptor 120 (GPR120) signaling pathway. However, natural activators of this receptor often lack sufficient strength and precision. TUG-891, a recently synthesized selective GPR120 activator, has displayed significant therapeutic potential in multiple disease.
View Article and Find Full Text PDFJ Epidemiol
September 2025
Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University.
Background: The potential impacts of polygenic scores (PGS) on health-behavior changes are not fully understood. The Iwate PGS Assessment and Risk Communication Study aims to investigate the effects of reporting PGS-based risk for ischemic stroke on health behaviors.
Methods: Participants wishing to know their PGS-based ischemic stroke risk were recruited from health checkup venues for workers in Iwate Prefecture in 2023.
World Neurosurg
September 2025
Department of Anaesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Electronic address:
Objective: The present study intends to conduct a comprehensive bibliometric analysis of the research pertaining to the treatment of vertebral artery stenosis, with the objective of elucidating the evolution and trends in therapeutic strategies.
Methods: A bibliometric analysis of publications spanning between January 1, 1980, and August 13, 2024, was conducted utilizing the Web of Science Core Collection database. The analysis and visualization of the data were performed using VOSviewer, CiteSpace, and R package "bibliometrix" software.
Brain Res Bull
September 2025
Jiangxi Key Laboratory of Neurological Diseases, Department of Neurosurgery, the 1(st) Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi, China. Electronic address:
Stroke is one of the leading causes of death and disability worldwide, with ischemic stroke accounting for the majority of cases. Intercellular communication is critical to its prognostic impact, and extracellular vesicles (EVs) are an emerging important mechanism. EVs are increasingly recognized as key mediators of crosstalk between neurons and glial cells, affecting processes such as neuroinflammation, oxidative stress and tissue repair.
View Article and Find Full Text PDFEnviron Res
September 2025
Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Background: Fine particulate matter (PM) has been previously linked to cardiovascular diseases (CVDs). PM is a mixture of components, each of which has its own toxicity profile which are not yet well understood. This study explores the relationship between long-term exposure to PM components and hospital admissions with CVDs in the Medicare population.
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