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Association Between Menopause Age and Estradiol-Based Hormone Therapy With Cognitive Performance in Cognitively Normal Women in the CLSA.
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Djavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, Canada.
Background And Objectives: Menopause and menopausal hormone therapy (MHT) affect cognition, although existing studies are inconclusive. Age-related declines in executive functions, episodic memory, and prospective memory may be differentially sensitive to menopause age and MHT, due to variations in which brain regions are involved and their estrogen receptor density. Few studies have explored how menopause age and estradiol (E2)-based MHT by administration route affect these domains, a gap that this study addresses.
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Mental Health Department, Tianjin Anding Hospital, Psychiatric Medical Center, Tianjin University, Mental Health Center of Tianjin Medical University, Tianjin, 300222, China.
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Introduction: Early life bilateral salpingo-oophorectomy (BSO) leads to immediate estradiol loss and increased risk of late-life Alzheimer's disease (AD). We investigated risk and resilience (RandR) on the average of 5 years post BSO and their possible impact on subjective cognitive decline (SCD), and brain structure.
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Do combined oral contraceptives have long-term effects? Little evidence of an enduring effect on cognitive function in former users.
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The use of combined oral contraceptives (COCs) is associated with subtle differences in brain activity and in certain cognitive, perceptual, or affective processes among current COC users compared with non-users. Whether any differences persist after the COCs are discontinued is essentially unknown. In a retrospective analysis of a cognitive dataset from healthy adults (N = 221, M = 23.
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