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We report the first case of canine lymphoadenomegalia caused by Cryptococcus neoformans in Chile. Physical examination of a Rottweiler dog patient showed a generalized lymphoadenomegalia that affected the submandibular, superficial cervical and popliteus lymphatic nodules. Cryptococcus neoformans was isolated and identified from biopsies of the right submandibular nodule. After antifungal susceptibility, oral ketoconazole treatment was established for a period of six months showing clinical improvement. Two years post-treatment the patient showed no signs of the infection.
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http://dx.doi.org/10.1016/s1130-1406(06)70052-3 | DOI Listing |
J Appl Toxicol
September 2025
Departamento de Bioquímica, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil.
Coagulant Moringa oleifera lectin (cMoL) is one of the compounds involved in the application of M. oleifera seeds for traditional water treatment methods. The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against Cryptococcus neoformans B3501 and H99 and Cryptococcus gattii R265 strains.
View Article and Find Full Text PDFJ Med Microbiol
September 2025
Department of Microbiology & Molecular Genetics, Oklahoma State University, Stillwater, OK, USA.
is an opportunistic fungal pathogen that causes pulmonary cryptococcosis, or an acute or chronic infection in the lungs, and cryptococcal meningitis, an infection of the brain and spinal column, in immunocompromised individuals. Fungal infections are responsible for ~1.7 million deaths each year.
View Article and Find Full Text PDFJ Infect Public Health
August 2025
Infection Control Center, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China; National Clinical Research Center for Geriatric Disorders (XiangYa Hospital), Changsha, Hunan Province 410008, China; Superbugs and Multidrug Resistant Microbes Infection Control Research Ce
Background: On October 25, 2022, the World Health Organization (WHO) released its first Fungal Priority Pathogen List (FPPL), classifying Cryptococcus neoformans (C. neoformans), Candida auris (C. auris), Aspergillus fumigatus (A.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Orthopedics, Xiangtan Central Hospital, Xiangtan, Hunan Province, China.
Rationale: Cryptococcal meningitis is caused by Cryptococcus neoformans and Cryptococcus gattii, predominantly affects immunocompromised host. Resistance to amphotericin B poses therapeutic challenges, especially in immunocompetent individuals, where evidence is scarce.
Patient Concerns: This study reports a case of an old immunocompetent male diagnosed with amphotericin B-resistant C neoformans meningitis.
Front Microbiol
August 2025
Post-graduate Program in Medicine and Biomedicine, Faculdade de Saúde Santa Casa de Belo Horizonte, Belo Horizonte, Brazil.
Protein Kinases (PKs) are a large family of enzymes that act as "molecular switches," playing fundamental role in cellular signaling through protein phosphorylation. This process consists in transfer a phosphate group (-PO₄) from ATP (adenosine triphosphate) to specific residues in target proteins; thereby, controlling vital cellular processes, such as (i) cell proliferation and differentiation, (ii) response to environmental stimuli (stress, nutrients, hormones), (iii) metabolism, (iv) cell cycle and apoptosis, and (v) signal transduction. Among fungi, adaptability is intrinsically connected to their ability to thrive under extreme environmental stress, being morphological plasticity an example of this adaptability.
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