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http://dx.doi.org/10.1002/smll.200600220 | DOI Listing |
Nat Nanotechnol
September 2025
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA.
Adoptive T-cell therapies, and particularly CAR T cells and tumour-infiltrating lymphocytes, have transformed cancer treatment by selectively targeting malignant cells. Despite their clinical success, these therapies face substantial challenges, including costly manufacturing processes and tumour-imposed barriers that limit efficacy. Advances in understanding the nanoscale mechanisms governing T-cell activation and the role of the tumour microenvironment in restricting T-cell responses have driven the development of nanotechnology-based strategies that integrate key chemical and physical cues.
View Article and Find Full Text PDFNanoscale
September 2025
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.
Precious metal nanomaterials have demonstrated significant advantages in the field of alcohol electro-catalytic oxidation. In this study, the inexpensive main group metals lead (Pb) and platinum (Pt) have been innovatively selected to construct an alloy catalyst. By employing the solvent-thermal method, PtPb nanoparticles with a well-defined crystalline structure were successfully synthesized, exhibiting excellent performance.
View Article and Find Full Text PDFMed Oncol
September 2025
Venom and Biotherapeutics Molecules Laboratory, Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Neuropeptide Y (NPY) and the voltage-gated potassium channel Kv1.3 are closely associated with breast cancer progression and apoptosis regulation, respectively. NPY receptors (NPYRs), which are overexpressed in breast tumors, contribute to tumor growth, migration, and angiogenesis.
View Article and Find Full Text PDFDalton Trans
September 2025
Department of Chemistry and Protein Research Center for Bio-Industry, Hankuk University of Foreign Studies, Yongin 17035, Republic of Korea.
The nanoscale environment within the void spaces of metal-organic frameworks (MOFs) can significantly influence the photoredox catalytic activity of encapsulated visible-light photoredox catalysts (PCs). To compare two isostructural PC@In-MOF systems, three cationic Ru(II) polypyridine complexes were successfully encapsulated within the mesoscale channels of the anionic framework of InTATB (HTATB = 4,4',4''--triazine-2,4,6-triyltribenzoic acid), which features a doubly interpenetrated framework structure. This encapsulation yielded three heterogenized visible-light PCs, RuL@InTATB, where L = 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen), or 2,2'-bipyrazine (bpz).
View Article and Find Full Text PDFNanoscale
September 2025
Department of Chemical and Biomolecular Engineering, National University of Singapore, 117576, Singapore.
Separation of xylene isomers, serving as indispensable feedstock in the petrochemical industry, is important but significantly challenging due to their similar physicochemical properties. With readily tunable network structures and chemical functionalities, metal-organic frameworks (MOFs) are promising for separation and many other potential applications. Here, we computationally design 150 lanthanide-based MOFs with one-dimensional triangular nanopores by varying metal compositions.
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