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In this study, three epigallocatechin gallate glycosides were synthesized by the acceptor reaction of a glucansucrase produced by Leuconostoc mesenteroides B-1299CB with epigallocatechin gallate (EGCG) and sucrose. Each of these glycosides was then purified, and the structures were assigned as follows: epigallocatechin gallate 7-O-alpha-D-glucopyranoside (EGCG-G1); epigallocatechin gallate 4'-O-alpha-D-glucopyranoside (EGCG-G1'); and epigallocatechin gallate 7,4'-O-alpha-D-glucopyranoside (EGCG-G2). One of these compounds (EGCG-G1) was a novel compound. The EGCG glycosides exhibited similar or slower antioxidant effects, depending on their structures (EGCG > or = EGCG-G1 > EGCG-G1' > EGCG-G2), and also manifested a higher degree of browning resistance than was previously noted in EGCG. Also, EGCG-G1, EGCG-G1', and EGCG-G2 were 49, 55, and 114 times as water soluble, respectively, as EGCG.
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http://dx.doi.org/10.1021/jf052359i | DOI Listing |
J Agric Food Chem
September 2025
Food & Nutritional Sciences Programme, School of Life Sciences, The Chinese University of Hong Kong, Shatin 999077, Hong Kong, China.
Epigallocatechin gallate (EGCG), a major catechin in green tea, was selected due to its dietary prevalence and potential synergistic functions with starch. Starch-EGCG complexes represent a form of type 5 resistant starch, but their effects on gut microbiota relative to starch chain-length distribution remain unclear. Using an in vitro fermentation model, we analyzed complexes derived from five starches.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Department of Pediatric Dentistry (Department of Preventive Dentistry), School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University, No.44-1 Wenhua Road West, 250012 Jinan, Shandong, China.
Guided bone regeneration (GBR) is a prominent focus in biomedical materials research, yet few studies address practical clinical needs. GBR membranes must fulfill the "PASS" principles to be effective in surgery, but existing membranes often fall short in balancing antibacterial activity, controlled degradation, osteoinductive potential, and mechanical support. In this study, we employed laser powder bed fusion (LPBF) to fabricate a porous WE43 magnesium alloy scaffold suitable for large alveolar bone defects.
View Article and Find Full Text PDFCrit Rev Food Sci Nutr
September 2025
Department of Analytical and Food Chemistry, Faculty of Science, Universidade de Vigo, Nutrition and Bromatology Group, Ourense, Spain.
The discovery of flavonoid amination metabolism has raised research interest in this new biotransformation mechanism. studies have revealed that flavonoids with pyrogallol structures readily react with N-nucleophilic ammonia, where amination occurs at intermediate -OH position, such as the B ring C4'-OH of epigallocatechin gallate and myricetin, A ring C6-OH of baicalein. Flavonoids are also covalently bound with amino acid residue by Schiff base, Michael addition or Strecker degradation, which are further rearranged to generate -NH substituted products.
View Article and Find Full Text PDFJ Mater Chem B
September 2025
State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Sichuan University, Chengdu, 610041, China.
Dentin caries is a multifactorial pathological process characterized by bacterial colonization and biofilm formation that result in concurrent acid-mediated demineralization and matrix metalloproteinase (MMP)-mediated degradation of the collagenous matrix. While remineralization therapies offer minimal invasiveness, their long-term efficacy is compromised by ongoing collagen degradation and persistent bacterial acid production that counteract remineralization efforts. To address these limitations, we designed PAMAM-G4@EG (PGE) nanoparticles (NPs) using polyamide amine (PAMAM) dendrimers as mineral deposition templates, with antimicrobial peptide G(IIKK)I-NH (G4) grafted onto the external surface groups and epigallocatechin gallate (EG) encapsulated within the internal cavities to provide biofilm disintegration and collagen protection for comprehensive dentin caries intervention.
View Article and Find Full Text PDFAlzheimer's disease (AD), a progressive neurodegenerative disorder, characterized by amyloid-beta (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, and neuroinflammation resulted the cognitive memory loss. Despite extensive research, effective therapeutic treatment remains elusive. Polyphenols, naturally occurring bioactive compounds, have emerged as promising neuroprotective agents due to their potent antioxidant, anti-inflammatory, and amyloid-modulating properties.
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