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The Earth undergoes continuous oscillations, and free oscillation peaks have been consistently identified in seismic records in the frequency range 2-7 mHz (refs 1, 2), on days without significant earthquakes. The level of daily excitation of this 'hum' is equivalent to that of magnitude 5.75 to 6.0 earthquakes, which cannot be explained by summing the contributions of small earthquakes. As slow or silent earthquakes have been ruled out as a source for the hum (except in a few isolated cases), turbulent motions in the atmosphere or processes in the oceans have been invoked as the excitation mechanism. We have developed an array-based method to detect and locate sources of the excitation of the hum. Our results demonstrate that the Earth's hum originates mainly in the northern Pacific Ocean during Northern Hemisphere winter, and in the Southern oceans during Southern Hemisphere winter. We conclude that the Earth's hum is generated by the interaction between atmosphere, ocean and sea floor, probably through the conversion of storm energy to oceanic infragravity waves that interact with seafloor topography.
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http://dx.doi.org/10.1038/nature02942 | DOI Listing |
J Am Chem Soc
August 2025
Engineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
Circular mRNA (mRNA) exhibits promising potential in mRNA therapy due to its increased stability and extended duration of protein translation, which has sparked an urgent demand for efficient methods to prepare circular RNAs . Here, we present a versatile self-circularization strategy that employs simple motifs to synthesize circular RNAs, achieving robust efficiencies for sequences ranging from dozens to thousands of nucleotides. By leveraging an automated computational program, we optimized highly specific lock-key structures to maximize circularization efficiency, particularly for long RNA substrates.
View Article and Find Full Text PDFJ Hum Evol
September 2025
Ephorate of Palaeoanthropology-Spelaeology, Hellenic Ministry of Culture, 34b Ardittou str., Athens 11636, Greece.
Assigning an age to the nearly complete cranium found in the Petralona Cave in Greece is of outstanding importance because this fossil has a key position in European human evolution. This topic has been debated since its discovery more than 60 years ago, highlighting the difficulties in applying physical dating methods to prehistoric samples. Previous results obtained on various types of samples yielded a large age range between about 170 and 700 ka, precluding any consensus on the age of the human fossil.
View Article and Find Full Text PDFJACS Au
July 2025
Engineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China.
Oligonucleotide therapeutics, especially antisense oligonucleotides (ASOs), provide promising treatments for various diseases, with combinatorial ASO therapy increasing the efficacy. However, challenges persist in enhancing stability and ensuring precise delivery. Here, we proposed the use of single-stranded circular ASOs (circASOs) for the cosilence of multiple genes, which was demonstrated with universality.
View Article and Find Full Text PDFIntroduction: With future manned missions that extend beyond low Earth orbit, it would be wise to anticipate all risks to astronaut health, including those relevant to ophthalmology and the ocular surface. Corneal edema has been documented among mice experiments conducted onboard the Space Transportation System mission, STS-133, owing to increased stress response gene expression.
Methods: A targeted, relevant search of the literature on topics relating to ocular surface and spaceflight was conducted with scholarly databases PubMed, Web of Science, and Embase from inception to July 2024.
Aerosp Med Hum Perform
June 2025
Introduction: Novel ocular findings have been identified in spaceflight. We discuss their potential association with Spaceflight Associated Neuro-ocular Syndrome (SANS) and integrate them in a framework that may help explain the pathophysiology.
Methods: We reviewed literature using the Medline/PubMed database starting in October 2020.