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Front Pharmacol
August 2025
Department of Genetics and Cell Biology, School of Basic Medicine, Qingdao University, Qingdao, Shandong, China.
Background: Osteoporosis (OP) is a chronic, systemic skeletal disorder characterized by progressive bone loss and microarchitectural deterioration, which increases fracture susceptibility and presents a challenging set of global healthcare problems. Current pharmacological interventions are limited by adverse effects, high costs, and insufficient long-term efficacy. Here, we identify snow crab shell-derived polypeptides (SCSP) as a potent osteoprotective agent.
View Article and Find Full Text PDFACS Nano
September 2025
Frontiers Science Center for Transformative Molecules, State Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.
Dynamic micro/nano-structured surfaces play pivotal roles in biological systems and engineering applications. Despite considerable progress has been made in fabricating precisely ordered architectures, achieving controlled motion in top-down fabricated structures remain a formidable challenge. Here, we introduce an advanced dynamic micron-nano optical platform featuring hierarchical microscale wrinkles integrated with ordered nanoscale arrays.
View Article and Find Full Text PDFAdv Mater
September 2025
College of Integrated Circuits & Micro-Nano Electronics, Fudan University, Shanghai, 200433, China.
High-operating-temperature (HOT) mid-wavelength and long-wavelength infrared photodetectors have emerged as critical enablers for eliminating bulky cryogenic cooling systems, offering transfromative potential in developing compact, energy-efficient infrared technologies with reduced size, weight, power, and cost. Focusing on infrared photodiodes, this review first discusses the fundamental mechanisms limiting performance at elevated operating temperatures. Subsequently, the progress in conventional epitaxial semiconductors, such as HgCdTe, InAsSb, and III-V type-II superlattice is reviewed, highlighting the evolution of device architectures designed to effectively suppress dark currents and approach background-limited performance.
View Article and Find Full Text PDFSkelet Muscle
September 2025
Sorbonne Université, Inserm, Institut de Myologie, Centre de Recherche en Myologie, Paris, France.
Duchenne muscular dystrophy (DMD) is a severe, progressive genetic disorder caused by mutations in the DMD gene, resulting in the absence of dystrophin-a key structural protein at the sarcolemma. As the disease progresses, cardiac involvement becomes a leading cause of morbidity and mortality. By adolescence or early adulthood, many patients develop dilated cardiomyopathy and arrhythmias.
View Article and Find Full Text PDFNat Commun
September 2025
Center for Advancing Electronics Dresden & Faculty of Chemistry and Food Chemistry, Technische Universität Dresden, Dresden, Germany.
The synthesis of thin crystalline two-dimensional polymers (2DPs) typically relies on reversible dynamic covalent reactions. While substantial progress has been made in solution-based and interfacial syntheses, achieving 2DPs through irreversible carbon-carbon coupling reactions remains a formidable challenge. Herein, we present an on-liquid surface (a mixture of N,N-dimethylacetamide and water, DMAc-HO) synthesis method for constructing diyne-linked 2DP (DY2DP) crystals via Glaser coupling, assisted by a perfluoro-surfactant (PFS) monolayer.
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