Advances of computational protein design: Principles, strategies and applications in nutrition and health.

Computational methods and AI technology have had a profound impact on protein design, significantly enhancing the ability to predict protein structures and create proteins with custom-tailored functions. With the help of computational methods, traditional protein design strategies such as directed evolution, fusion protein, and key subunit interface redesign show unprecedented progress in the design of various protein biomaterials such as nanocages, nanocarriers, antibodies, biocatalytic enzymes and inhibitory peptides. Strategies include physics-mediated design, which leverages the physical principles underlying protein structure and dynamics, and AI-mediated design, which employs machine learning techniques to generate and optimize protein configurations.

Stabilizing Lattice Oxygen to Enable Durable MnO Electrocatalyst for Simultaneous Acidic Hydrogen Production and Biomass Valorization.

Understanding and steering the stability of earth-abundant electrocatalysts in acidic medium is essential for proton exchange membrane (PEM) water electrolyzer. Manganese oxide (MnO) is one of the promising candidates for acidic oxygen evolution reaction (OER), but it still suffers from the overoxidation and the underlying mechanism remains elusive. Here, we observed that lattice oxygen was involved in the OER process on γ-MnO via Mars-van-Krevelen mechanism.

Expansion of T follicular helper cells is associated with disease progression in rat experimental membranous nephropathy model.

Background: T follicular helper (Tfh) cells drive humoral immunity by facilitating B cell responses, but the functional role of Tfh cells in the pathogenesis of idiopathic membranous nephropathy (IMN) remains unclear.

Objectives: This study aimed to establish a rat experimental membranous nephropathy model, investigate the phenotypic characteristics of Tfh cells, and analyze a clinically significant correlation between Tfh cells.

Material And Methods: Passive Heymann nephritis (PHN) rats were induced by immunizing Sprague Dawley rats with anti-Fx1A serum.

Triptolide inhibits the proinflammatory potential of myeloid-derived suppressor cells via reducing Arginase-1 in rheumatoid arthritis.

Triptolide (TPT) is widely used in the treatment of rheumatoid arthritis (RA). However, its regulatory mechanisms are not fully understood. This study demonstrated that Myeloid-derived suppressor cells (MDSCs) were expanded in both RA patients and arthritic mice.

Environmental tobacco smoke increased risk of gestational diabetes mellitus: A birth cohort study in Sichuan, China.

Introduction: Studies on the relationship between environmental tobacco smoke (ETS) and gestational diabetes mellitus (GDM) are limited. In this study, we aimed to clarify the association between ETS at different trimesters of pregnancy and the risk of GDM among non-smoking pregnant women.

Methods: A total of 16,893 non-smoking mothers from the Southwest Birth Cohort, China, were included in the final analyses.

Elevated circulating CD19CD24CD38 B cells display pro-inflammatory phenotype in idiopathic membranous nephropathy.

CD19CD24CD38 regulatory B cells exert immunosuppressive functions by producing IL-10, but their role in idiopathic membranous nephropathy (IMN) remains elusive. Here, we investigated the frequency and functional changes of circulating CD19CD24CD38 B cells and evaluated the correlation of CD19CD24CD38 B cells with clinical features and T helper cell subsets in IMN patients. Compared with healthy controls (HCs), IMN patients showed an increased frequency of CD19CD24CD38 B cells, but a significant reduction in the percentage of CD19CD24CD38 B cells was observed 4 weeks after cyclophosphamide treatment.

Analysis of characteristics and forecast of unintentional injury deaths of children under age 5 from 2013 to 2019 in Sichuan, China.

Objective: Through the study of death characteristics and trend prediction, it is hoped that key populations, regions and seasons can be identified, thereby providing evidence support for the efficient prevention and control management of unintentional injury deaths.

Method: We collected information on 8630 unintentional deaths of children under age 5 from local surveillance systems, analyzed by chi-square test and predicted by the seasonal ARIMA model.

Results: About 33.

[Retracted] MicroRNA‑655 inhibits cell proliferation and invasion in epithelial ovarian cancer by directly targeting vascular endothelial growth factor.

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the cell invasion assay data shown in Figs. 2C and 4C were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to , the Editor has decided that this paper should be retracted from the Journal.

Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring.

Maternal periconceptional folic acid supplementation (FAS) has been documented to be associated with decreased risk of nonsyndromic oral clefts (NsOC). However, the results remain inconclusive. In this population-based case-control study of 807 singletons affected by NsOC and 8070 healthy neonates who were born between October 2010 and September 2015 in Chengdu, China, we examined the association of maternal FAS with the risk of nonsyndromic cleft lip with or without cleft palate (NsCL/P), and cleft palate (NsCP).

Ethnic disparity in pneumonia-specific mortality among children under 5 years of age in Sichuan Province of Western China from 2010 to 2017.

Background: To reveal the ethnic disparity in the pneumonia-specific mortality rates of children under the age of 5 years (PU5MRs) and provide suggestions regarding priority interventions to reduce preventable under-five-years-of-age deaths.

Methods: Data were obtained from the Direct Report System of Maternal and Child Health in Sichuan. The Cochran-Armitage trend test was used to assess the time trend.

All-cause child mortality in minority and non-minority areas in Sichuan Province in Western China, 2008-2017.

This study aimed to evaluate the disparity in the under-five mortality rate (U5MR) between minority and non-minority areas in Sichuan Province in Western China. Data for this study was obtained from the National Health Statistics Survey System. The Cochran-Armitage trend test was used to analyze the time trend of the U5MR.

Unintentional injury mortality among children under age five in urban and rural areas in the Sichuan province of west China, 2009-2017.

This study analysed trends in the unintentional injuries specific mortality rates among children under age five (UI-specific U5MRs) in urban and rural areas in the Sichuan province of western China. Data were obtained from the National Health Statistics Survey System. The Cochran-Armitage trend test was used to analyse the trends in UI-specific U5MRs and the proportion of unintentional injury deaths to total deaths.

MicroRNA‑655 inhibits cell proliferation and invasion in epithelial ovarian cancer by directly targeting vascular endothelial growth factor.

In recent years, microRNAs (miRNAs/miRs) have been shown to be deregulated in epithelial ovarian cancer (EOC). Their deregulation has been suggested to be involved in EOC formation and progression through the regulation of the expression of numerous cancer‑related genes. Hence, it is of great importance to further determine the detailed roles and underlying mechanisms of miRNAs involved in EOC and to identify novel targets for diagnosis, prognosis and treatment of patients with EOC.

Disparities in health system input between minority and non-minority counties and their effects on maternal mortality in Sichuan province of western China.

Background: The maternal mortality rate (MMR) markedly decreased in China, but there has been a significant imbalance among different geographic regions (east, central and west regions), and the mortality in the western region remains high. This study aims to examine how much disparity in the health system and MMR between ethnic minority and non-minority counties exists in Sichuan province of western China and measures conceivable commitments of the health system determinants of the disparity in MMR.

Methods: The MMR and health system data of 67 minority and 116 non-minority counties were taken from Sichuan provincial official sources.

[Trend analysis on mortality and the mortal causes among children under 5 in Sichuan province, from 2001 to 2013].

Objective: To study the mortality of children under five and the causes of death together with related trend of dynamics, from 2001 to 2013 in Sichuan province.

Methods: Using the Children Death Monitoring Network under five in Sichuan province to obtain basic data. Descriptive statistics and chi-square were used to describe the mortalities in children and infants as well as the causes of death, in both rural and urban areas of Sichuan province.

16S ribosomal DNA clone libraries to reveal bacterial diversity in anaerobic reactor-degraded tetrabromobisphenol A.

Microorganisms able to rapidly degrade tetrabromobisphenol A (TBBPA) were domesticated in an anaerobic reactor and added to gradually increased concentrations of TBBPA. After 240 days of domestication, the degradation rate reached 96.0% in cultivated batch experiments lasting 20 days.