SLC7A11 upregulation via AR and NEDD4L ubiquitination contributes to ferroptosis inhibition and enzalutamide resistance in castration-resistant prostate cancer.

Advanced prostate cancer (PCa) is associated with a poor prognosis, particularly in patients who progress to castration-resistant prostate cancer (CRPC). The emergence of enzalutamide (Enz), a second-generation androgen receptor inhibitor, has effectively extended the median survival of these patients. However, drug resistance frequently develops during clinical use.

Surge Dose Formulations of NSAIDs Provide for Ultra-Rapid and Consistent Drug Absorption in Both the Fasted and Fed State as Predicted by Physiologically Based Biopharmaceutics Modelling.

This paper describes the use of physiologically based biopharmaceutics modelling (PBBM) to predict the effect of food on diclofenac and ibuprofen absorption from ultra-rapid-release Surge Dose tablets. Fasted-state diclofenac pharmacokinetics (PK) were used with published IV data and biorelevant dissolution data for the diclofenac tablets to develop a mechanistic PBBM model which could be used to predict absorption. The resultant model that best fitted the PK data showed that, in vivo, the ultra-rapid-release tablets behaved like a solution with a median time to peak plasma concentration (T) of 20 min.

Metabolic biomarkers mediate allergic rhinitis via circulating inflammatory proteins: Evidence from a Mendelian randomization study.

Objective: Allergic Rhinitis (AR), a prevalent allergic condition, markedly diminishes quality of life and increases public health burdens. This study investigated the mediating roles of Metabolic Biomarkers (MBs) in the associations between Circulating Inflammatory Proteins (CIPs) and AR, aiming to uncover novel therapeutic targets.

Methods: Utilizing Mendelian Randomization (MR), we leveraged genetic variants as instrumental variables to delineate causal relationships between CIPs and AR.

Quantum Dot Nanoprobes for Microvascular Thromboembolism Therapy via Ultrasound and Near-Infrared Dual-Mode Approach.

Thromboembolism can lead to ischemic damage in vital organs and, in severe cases, become life-threatening. A major challenge in its treatment is that, despite conventional clinical therapies, thromboembolic occlusions in the microvasculature often persist, making them difficult to remove completely and effectively, with limited improvement in patient outcomes. In this study, a novel approach to treating microvascular thromboembolism is proposed by utilizing the imaging and photothermal properties of quantum dots.

Cuticle protein mediates the evolution of stress resistance by generating a decoy circular RNA in spider mite.

Phytophagous mites, including , are arthropods known for their wide infestation of host plants and pesticide resistance. We found that fenpropathrin-resistant female mites (YN-FeR, with target resistance: F1538I mutation) exhibited significantly enhanced adaptability to various stress conditions, including exposure to different acaricides and high-temperature (34°C) and low-humidity environments (40% relative humidity). This evolution was attributed to cuticle thickening in resistant female mites.

Zn-thiocatecholate functionalized MOF modified separator stabilizing zinc anodes for long-life aqueous zinc-ion batteries.

A separator (UiO-dcbdt-Zn@GF) modified by Zn-thiocatecholate functionalized MOF is proposed. Benefiting from the unique [S-Zn-S] zincophilic moieties, UiO-dcbdt-Zn@GF ensures a uniform distribution of zinc ion flux, enhances ion migration kinetics and assists in the desolvation of hydrated zinc ions, thereby promoting the reversibility of Zn anode in Zn ion batteries.

Lycium barbarum glycopeptide reduces inflammation and fibrosis in corneal injury by modulating the NF-κB/NLRP3/IL-1 β signaling pathway and microRNA-21a-5p/SMAD7.

Lycium barbarum glycopeptide (LbGp), derived from the Chinese medicinal plant Lycium barbarum, has demonstrated anti-inflammatory properties; however, its precise role and mechanism in corneal repair following injury remain elusive. The present research investigated the mechanisms and effects of LbGp on corneal repair following alkali burn injury using in vivo mouse models of corneal alkali burn and in vitro human keratocyte fibrosis models. Corneal inflammation, opacity, and epithelial defects were assessed via a slit lamp microscope.

Glioblastoma with metastasis to the bone marrow.

Extraneural metastasis of glioblastoma (GBM) is rare but expected to increase in incidence as patients live longer. We present a rare case of GBM that has metastasised to the bone marrow shortly after completing standard of care treatment. This case highlights the importance of having a high index of suspicion, using next-generation sequencing testing and the urgent need for further research to identify treatment options for this population.

Harnessing Coordination Microenvironment of Metal-bis(dithiolene) Sites for Modulating Electrocatalytic CO Reduction by Metal-Organic Framework.

Nature's metalloenzymes inspire biomimetic catalysts for the CO reduction reaction (CORR), particularly using metal-bis(dithiolene) ([MS]) cores in frameworks. While prior research focused on tuning the chelating atoms of Ni-centered sites or [NiS] in metal-organic frameworks (MOFs), how different metal centers affect the electronic structure and catalytic activity is often overlooked. Notably, reported [NiS] molecular analogues exhibits a Faradaic efficiency (FE) of less than 70% for the major carbon product and shows operational stability for only about 4 hours (say falling FE and current density beyond).

Metabolic Biomarkers Mediate Allergic Conjunctivitis via Circulating Inflammatory Proteins: Evidence From a Mendelian Randomization Study.

Purpose: This study aimed to investigate the mediating role of metabolic biomarkers (MBs) in the association between circulating inflammatory proteins (CIPs) and allergic conjunctivitis (AC) and identify potential therapeutic targets.

Methods: A Mendelian randomization (MR) study was conducted, leveraging genetic variants as instrumental variables to infer causal relationships. Data were obtained from genome-wide association studies (GWASs), and a two-sample MR was employed to estimate the direct and indirect effects of CIPs on AC through MBs.

The Outcomes of Physiological Ventricular Rhythm Resetting With AV Node Ablation and Left Bundle Branch Pacing in Patients With AF-Induced Cardiomyopathy: A Prospective Cohort Study.

The mechanism of AF-induced cardiomyopathy (AF-CM) is still unclear. Expect for heart rate, atrial contraction lost and ventricular rhythm irregularity are believed as possible contributors to AF-CM. This study aimed to investigate ventricular rhythm irregularity effects on AF-CM.

AURKB as a Therapeutic Target and Key Driver of Liver Cancer Growth and Metastasis.

Hepatocellular carcinoma (HCC) is a major cause of cancer-related deaths worldwide. Aurora kinase B (AURKB), a critical regulator of mitosis, has been implicated in cancer progression, though its precise role in HCC remains unclear. In this study, AURKB expression was found to be significantly elevated in HCC tissues and cell lines compared to controls, as validated by GEPIA and ENCORI databases.

Exploring causal relationships between circulating micronutrients and age-related eye diseases: a Mendelian randomization study.

Background: With the global population aging, age-related eye diseases (AREDs) such as senile cataract (SC), age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy (DR) are becoming increasingly significant public health concerns. The rising prevalence of AREDs underscores the urgent need for effective prevention and treatment strategies. This study aimed to explore the causal relationships between circulating micronutrients (CMs) and AREDs.

Effect of Direct Cyclopexy for Traumatic Cyclodialysis Cleft: A Retrospective Clinical Study.

Purpose: To evaluate the clinical effects of direct cyclopexy in the treatment of traumatic cyclodialysis cleft.

Methods: This is a retrospective case study. Patients with traumatic cyclodialysis cleft, who were treated with direct cyclopexy and had complete medical records at Tianjin Eye Hospital between February 2021 and August 2022 were selected.

Molecular Subtype Identification and Potential Drug Prediction Based on Anoikis-Related Genes Expression in Keratoconus.

Purpose: Anoikis is a special apoptosis accompanied by the loss of extracellular matrix (ECM) environment and the decomposition of ECM is an important process in the occurrence of keratoconus (KC). This study aims to describe the expression profile of anoikis-related genes (ARGs) in KC samples, identify differentially expressed genes (DEGs), characterize the biological functions and immune characteristics of different molecular subtypes of KC and predict potential drugs based on the construction of a co-expression network.

Methods: First, we identified molecular subtypes by optimal clustering K based on the expression profile of ARGs in the KC dataset and analyzed the differences of functional and immune characteristics.

Left Bundle Branch Pacing Impact on QRS Amplitude in Different Pacing Voltages.

Background: Left bundle branch pacing (LBBP) emerged as a novel physiological pacing modality that improves clinical outcomes. This study aimed to explore the impact of LBBP on QRS wave amplitude (RWA).

Methods: This prospective observational study included patients with complete left bundle branch block (CLBBB) and cardiac resynchronization therapy (CRT) indication, as well as patients with QRSd < 120 ms and pacemaker indication.

Ultra-High Purity and Productivity Separation of CO and CH from CH in Rigid Layered Ultramicroporous Material.

Efficiently obtaining both high-purity gas-phase and adsorbed-phase products in a single physisorption process presents the challenge of simultaneously achieving high selectivity and uptake and rapid diffusion in adsorbents. With a focus on natural gas purification and high-purity acetylene production, we report for the first time that the synergistic ligand/anion binding mode and multiple diffusion pathways in a robust 2D layered ultramicroporous framework (ZUL-100) enable unprecedented carbon dioxide/methane and acetylene/methane separation performance. Taking advantage of its rich anion, functional ligand ,and rigid 3D interpenetrated ultramicroporous channels, ZUL-100 achieved record IAST selectivities for equimolar carbon dioxide/methane (3.

Cost-Effectiveness Ratio Analysis of LBBaP Versus BVP in Heart Failure Patients With LBBB.

Background: For the initial treatment strategy for patients with cardiac resynchronization therapy (CRT) indications, whether to choose left bundle branch area pacing (LBBaP) or biventricular pacing (BVP) remains controversial. We aimed to investigate the cost-effectiveness ratio (CER) of LBBaP and BVP in heart failure (HF) patients with left bundle branch block (LBBB).

Methods: This observational study included HF patients with LBBB who underwent successful LBBaP or BVP.

Predictors of functional mitral regurgitation improvement in patients with left bundle branch block treated with left bundle branch area pacing.

Background: Functional mitral regurgitation (FMR) and its severity are associated with adverse outcomes in heart failure patients. This study aims to analyze the predictors of FMR improvement after successful left bundle branch area pacing (LBBAP) in patients with LVEF < 50% and complete left bundle branch block (CLBBB).

Methods: Consecutive patients with LVEF < 50% and CLBBB who underwent successful LBBAP from July 2018 to July 2023 were retrospectively identified.

2D metal-organic frameworks bearing butterfly-shaped metal-bis(dithiolene) linkers from dithiol-functionalized benzenedicarboxylic acid.

An assembly between 1,4-dicarboxylbenzene-2,3-dithiol (Hdcbdt) and different transition metal ions successfully produced 2D metal-organic frameworks (M-dcbdt, M = Ni, Co or Fe) composed of unprecedented butterfly-shaped metal-bis(dithiolene) (MS) linkers in one-pot fashion. Such strategy provides easier access to the [MS]-rich network and lowers the prerequisite to explore their applications.

Molecular hydrogen promotes retinal vascular regeneration and attenuates neovascularization and neuroglial dysfunction in oxygen-induced retinopathy mice.

Background: Retinopathy of Prematurity (ROP) is a proliferative retinal vascular disease occurring in the retina of premature infants and is the main cause of childhood blindness. Nowadays anti-VEGF and retinal photocoagulation are mainstream treatments for ROP, but they develop a variety of complications. Hydrogen (H) is widely considered as a useful neuroprotective and antioxidative therapeutic method for hypoxic-ischemic disease without toxic effects.

MicroRNA-204-5p Attenuates Oxidative Stress, Apoptosis and Inflammation by Targeting TXNIP in Diabetic Cataract.

Diabetic cataract (DC) is a major cause of blindness in diabetic patients and it is characterized by early onset and rapid progression. MiR-204-5p was previously identified as one of the top five down-regulated miRNAs in human DC lens tissues. We aimed to determine the expression of miR-204-5p in human lens epithelial cells (HLECs) and explore its effects and mechanisms in regulating the progression of DC.

Dual-mode nanoprobe strategy integrating ultrasound and near-infrared light for targeted and synergistic arterial thrombolysis.

Efficient thrombolysis in time is crucial for prognostic improvement of patients with acute arterial thromboembolic disease, while limitations and complications still exist in conventional thrombolytic treatment methods. Herein, our study sought to investigate a novel dual-mode strategy that integrated ultrasound (US) and near-infrared light (NIR) with establishment of hollow mesoporous silica nanoprobe (HMSN) which contains Arginine-glycine-aspartate (RGD) peptide (thrombus targeting), perfluoropentane (PFP) (thrombolysis with phase-change and stable cavitation) and indocyanine green (ICG) (thrombolysis with photothermal conversion). HMSN is used as the carrier, the surface is coupled with targeted RGD to achieve high targeting and permeability of thrombus, PFP and ICG are loaded to achieve the collaborative diagnosis and treatment of thrombus by US and NIR, so as to provide a new strategy for the integration of diagnosis and treatment of arterial thrombus.