Comparison of biparameter and multiparameter MRI in detection of clinically significant prostate cancer across PSA stratifications.

Background: The comparative diagnostic performance of biparametric MRI (bpMRI) versus multiparametric MRI (mpMRI) for clinically significant prostate cancer (csPCa) continues to be debated. This study aimed to compare mpMRI and bpMRI in detecting csPCa across prostate-specific antigen (PSA) strata and identify supplementary tools comparable to dynamic contrast-enhanced (DCE) imaging.

Methods: Images were evaluated using mpMRI-based mp-PI-RADS and bpMRI-based bp-PI-RADS and simplified PI-RADS (S-PI-RADS) schemes.

Mesenchymal stem cell membrane camouflaged mesoporous polydopamine for Parkinson's disease treatment via alleviating oxidative stress mediated neuroinflammation.

Excessive accumulation of reactive oxygen species (ROS) in Parkinson's disease (PD) leads to oxidative stress, which induces neuroinflammation and accelerates disease progression. To address this, we developed mPDA@MSC, a nanosystem consisting of mesoporous polydopamine (mPDA) nanoparticles coated with a mesenchymal stem cell membrane (MSCm), which exhibits ROS-scavenging properties. The mPDA structure significantly enhanced ROS-scavenging and anti-inflammatory activities, while the surface-encapsulated MSCm enabled effective blood-brain barrier traversal and targeted the lesion site in the PD brain.

A comprehensive scoring system integrating clinical and radiological variables for the detection of clinically significant prostate cancer on bi-parameter MRI: multi-center comparison with multi-parametric MRI.

Purpose: To develop and validate a scoring system that combines clinical and radiological variables to predict the likelihood of clinically significant prostate cancer (csPCa, which is defined as Gleason Grade group ≥ 2) before biopsy and stratify patients by predicted risk.

Methods: This retrospective study enrolled 788 patients. Data were stratified into a derivation cohort and two validation cohorts by institutions.

Evolution of cooperation with Q-learning: The impact of information perception.

The inherent complexity of human beings manifests in a remarkable diversity of responses to intricate environments, enabling us to approach problems from varied perspectives. However, in the study of cooperation, existing research within the reinforcement learning framework often assumes that individuals have access to identical information when making decisions, which contrasts with the reality that individuals frequently perceive information differently. In this study, we employ the Q-learning algorithm to explore the impact of information perception on the evolution of cooperation in a two-person prisoner's dilemma game.

Endovascular Treatment and Hybrid Surgery for Extracranial Internal Carotid Artery Aneurysms.

Background: Extracranial internal carotid artery aneurysms (EICAAs) are rare, and both endovascular treatment and hybrid surgery have been used to treat them. Herein, we evaluated the outcomes of endovascular treatment and hybrid surgery for EICAAs treated at our institution.

Methods: Twenty-eight patients diagnosed with EICAA and treated with endovascular treatment or hybrid surgery in our center from January 2013 to June 2023 were retrospectively reviewed.

Long-term Outcomes of Endovascular Versus Medical Treatment for Isolated Superior Mesenteric Artery Dissection: A 10-Year Retrospective Study.

Purpose: Isolated superior mesenteric artery dissection (IMAD) is increasing in prevalence. Both endovascular and medical treatments are frequently used, but based on studies with relatively small sample sizes and limited follow-up. This article aims to compare the long-term outcomes of medical treatment versus endovascular treatment for isolated superior mesenteric artery dissection.

Development and validation of risk-stratified biopsy decision pathways incorporating MRI and PSA-derived indicators.

Objectives: Develop risk-adapted conditional biopsy pathways utilizing MRI in combination with prostate-specific antigen (PSA) density (PSAD) and the ratio of free to total PSA (f/tPSA), respectively, to enhance the detection of clinically significant prostate cancer (csPCa) while minimizing 'negative' biopsies in low-risk patients.

Methods: The Prostate Imaging Reporting and Data System (PI-RADS) category, PSAD, f/tPSA and biopsy-pathology of 1018 patients were collected retrospectively. Subsequently, PSAD and f/tPSA were divided into four intervals, which were then combined with the MRI findings to construct two risk stratification matrix tables.

Neural function of Bmal1: an overview.

Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor central to the transcription/translation feedback loop of the biologic clock. Although Bmal1 is well-established as a major regulator of circadian rhythm, a growing number of studies in recent years have shown that dysfunction of Bmal1 underlies a variety of psychiatric, neurodegenerative-like, and endocrine metabolism-related disorders, as well as potential oncogenic roles. In this review, we systematically summarized Bmal1 expression in different brain regions, its neurological functions related or not to circadian rhythm and biological clock, and pathological phenotypes arising from Bmal1 knockout.

[Preparation and characterization of a polyclonal antibody against mouse NH2;-terminal domain of polycystin-1].

Objective: To produce a rabbit polyclonal antibody, mPkd1-Np, against the extracellular portions of polycystin-1 (PC1) in order to explore the functional roles of the PC1 NH2;-terminus.

Methods: Based on hydrophobic/hydrophilic analyses, we chose a cDNA fragment that encodes amino acids 474E-640L on PC1 and amplified it via RT-PCR. The PCR product was then cloned into a prokaryotic expression vector pGEX-GST.

[Preparation and characterization of a polyclonal antibody against human Fibrocystin-L].

Aim: PKHDL1 (the gene for Polycystic Kidney and Hepatic Disease Like-1) had been recently identified, but characteristics of the gene product, Fibrocystin-L (FPC-L), still remain unknown. We therefore produced a rabbit polyclonal antibody hFL-Np to explore the cellular characteristics of this novel protein.

Methods: Based on the hydrophobic/hydrophilic analyses, chose a cDNA fragment which encodes 633L-768K amino acids of the FPC-L and amplified it by RT-PCR.

Age scope of high-risk population for esophageal cancer in Ci county.

Aim: To define the age scope of high-risk population for esophageal cancer (EC) in Ci county.

Methods: The results of endoscopic examination of 2 013 subjects, cytological screening of 16 763 persons and records of 9 265 patients with EC were analyzed by Ridit methods, the standard age group was 45-49 year group.

Results: The average age of patients with moderate esophageal epithelium dysplasia by endoscopic examination was 53.

Field population-based blocking treatment of esophageal epithelia dysplasia.

Aim: To confirm the value of blocking treatment by zenshengping (ZSP), a Chinese herb composite, and Riboflavin for esophageal epithelia dysplasia cases screened out in high risk area in northern china by exfoliative balloon cytology (EBC), so to reduce the incidence rate of esophageal cancer(EC).

Methods: Esophageal epithelium dysplasia cases including mind esophageal epithelium dysplasia (MEED), stage one severe esophageal epithelium dysplasia (SEED I), and stage two severe esophageal epithelium dysplasia (SEED II) were screened out from people aged 40 years and older in the high risk area of Chixian. These cases were randomly divided into a treatment and control group.