Bidirectional Hydrogen Spillover Enables High Activity Catalysts for Rechargeable Hydrogen Batteries.

Rechargeable hydrogen batteries exhibit superior electrochemical activity for hydrogen evolution and oxidation reactions (HER/HOR) in acidic media compared to alkaline counterparts, making them promising for large-scale energy storage. However, the development of efficient electrocatalysts for both HER and HOR in acidic media remains challenging, as conventional platinum-based catalysts face intrinsic limitations in simultaneously achieving high activity and long-term stability under harsh operating conditions. Herein, we introduce a bidirectional hydrogen spillover strategy to enable synergistic bifunctional HER/HOR catalysts for hydrogen batteries.

Iridium-Free High-Entropy Alloy for Acidic Water Oxidation at High Current Densities.

Designing active and cost-effective catalysts for acidic oxygen evolution reaction (OER) is critically important for improving proton exchange membrane water electrolyzers (PEMWEs) used in hydrogen production. In this study, we introduce a rapid and straightforward method to synthesize a quinary high-entropy ruthenium-based alloy (RuMnFeMoCo) for acidic OER. This iridium-free catalyst demonstrates a low overpotential of 170 mV and exceptional stability, enduring a 1000-hour durability test at 10 mA cm in 0.

Analysis and validation of programmed cell death genes associated with spinal cord injury progression based on bioinformatics and machine learning.

Background: Spinal cord injury (SCI) is a severe condition affecting the central nervous system. It is marked by a high disability rate and potential for death. Research has demonstrated that programmed cell death (PCD) plays a significant role in the death of neuronal cells during SCI.

A High-Capacity Manganese-Metal Battery with Dual-Storage Mechanism.

As a promising post lithium-ion-battery candidate, manganese metal battery (MMB) is receiving growing research interests because of its high volumetric capacity, low cost, high safety and high energy-to-price ratio. However, the low energy density, mainly constrained by scarce choices and unsatisfying capacity of cathodes, strictly bottlenecks the development of MMBs. In this work, a new class of cathodes based on novel dual-storage mechanism (DSM) are reported.

Rechargeable alkali metal-chlorine batteries: advances, challenges, and future perspectives.

The emergence of Li-SOCl batteries in the 1970s as a high-energy-density battery system sparked considerable interest among researchers. However, limitations in the primary cell characteristics have restricted their potential for widespread adoption in today's sustainable society. Encouragingly, recent developments in alkali/alkaline-earth metal-Cl (AM-Cl) batteries have shown impressive reversibility with high specific capacity and cycle performance, revitalizing the potential of SOCl batteries and becoming a promising technology surpassing current lithium-ion batteries.

Surgical Treatment of Brucellar Cervical Epidural Abscess.

Objectives: Brucellar cervical epidural abscess (CEA) is a rare condition with potentially permanent neurological damage if left untreated. This study aims to define the clinical presentation of brucellar CEA and evaluate the outcome of surgical treatment, specifically decompression and fusion surgery. The findings will contribute to understanding whether all patients with brucellar CEA could benefit from this surgical intervention.

Recent advances in nanomaterials for the treatment of spinal cord injury.

Spinal cord injuries (SCIs) are devastating. In SCIs, a powerful traumatic force impacting the spinal cord results in the permanent loss of nerve function below the injury level, leaving the patient paralyzed and wheelchair-bound for the remainder of his/her life. Unfortunately, clinical treatment that depends on surgical decompression appears to be unable to handle damaged nerves, and high-dose methylprednisolone-based therapy is also associated with problems, such as infection, gastrointestinal bleeding, femoral head necrosis, obesity, and hyperglycemia.

Hydrogels in Spinal Cord Injury Repair: A Review.

Traffic accidents and falling objects are responsible for most spinal cord injuries (SCIs). SCI is characterized by high disability and tends to occur among the young, seriously affecting patients' lives and quality of life. The key aims of repairing SCI include preventing secondary nerve injury, inhibiting glial scarring and inflammatory response, and promoting nerve regeneration.

Characterization of human induced pluripotent stem cells line JLUEYEi002-A from a 48 year old healthy male.

Peripheral blood was extracted from a 48-year old healthy male donor. Induced pluripotent stem cells (iPSC) were reprogrammed by sendai virus encoding Klf-4, c-Myc, Oct-4, and Sox-2. The iPSC line showed pluripotency, which was verified by immunofluorescence staining.

Generation and characterization of human induced pluripotent stem cells line JLUEYEi001-A from a 45 year old female with Stickler syndrome.

Peripheral blood was extracted from a 45-year old female patient clinically diagnosed with Stickler syndrome harboring a heterozygous splicing mutation in COL2A1 (NM_033150, IVS22-1C>T). Induced pluripotent stem cells (iPSC) were reprogrammed by sendai virus encoding Klf-4, c-Myc, Oct-4, and Sox-2. The iPSC line showed pluripotency, which was verified by immunofluorescence staining.

Evaluation of microstructural changes in spinal cord of patients with degenerative cervical myelopathy by diffusion kurtosis imaging and investigate the correlation with JOA score.

Background: To explore the feasibility of the metrics of diffusion kurtosis imaging (DKI) for investigations of the microstructural changes of spinal cord injury in patients with degenerative cervical myelopathy (DCM) and the correlation between Japan Orthopaedic Association (JOA) scores and DKI metrics.

Methods: Fifty-seven patients with DCM and 38 healthy volunteers underwent 3.0 T magnetic resonance (MR) imaging with routine MRI sequences and DKI from echo-planar imaging sequence.

Circular RNA PVT1 promotes metastasis via regulating of miR-526b/FOXC2 signals in OS cells.

As a class of covalently closed non-coding RNAs, circular RNAs (circRNAs) are key regulators in various malignancies including osteosarcoma (OS). In the present study, we found that circular RNA PVT1 (circPVT1) was up-regulated in OS and correlated with poor prognosis of patients with OS. Functionally, we showed that knockdown of circPVT1 suppressed OS cells metastasis.

Percutaneous endoscopic lumbar discectomy by transfacet joint approach: A case report.

Rationale: The accurate and smooth establishment of a working cannula guarantees rapid and minimally invasive treatment effects using percutaneous endoscopic lumbar discectomy (PELD) for lumbar disc herniation (LDH). With anatomic variations such as a hyperplastic superior articular process (SAP), the conventional transforaminal approach cannot achieve an ideal result.

Patient Concerns: A 48-year-old male patient suffered waist and left lower limb pain, with exacerbation of symptoms after exertion.

Generation of a human induced pluripotent stem cell (iPSC) line from a 64year old male patient with multiple schwannoma.

Peripheral blood was collected from a clinically diagnosed 64-year old male multiple schwannoma patient. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining for pluripotency markers, and the iPSC line was able to differentiate into the 3 germ layers in vivo.

Derivation of human induced pluripotent stem cell (iPSC) line from a 79year old sporadic male Parkinson's disease patient.

Peripheral blood was collected from a clinically diagnosed 79-year old male sporadic Parkinson's disease patient. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining for pluripotency markers, and the iPSC line was able to differentiate into the 3 germ layers in vivo.

Characterization of human induced pluripotent stem cell (iPSC) line from a 72year old male patient with later onset Alzheimer's disease.

Peripheral blood was collected from a clinically diagnosed 72-year old male patient with later onset Alzheimer's disease. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining for pluripotency markers, and the iPSC line was able to differentiate into the 3 germ layers in vivo.

Development of human induced pluripotent stem cell (iPSC) line from a 60year old female patient with multiple schwannoma.

Peripheral blood was collected from a clinically diagnosed 60-year old female patient with multiple schwannoma. Peripheral blood mononuclear cells (PBMCs) were reprogrammed with the Yamanaka KMOS reprogramming factors using the Sendai-virus reprogramming system. The transgene-free iPSC line showed pluripotency verified by immunofluorescent staining for pluripotency markers, and the iPSC line was able to differentiate into the 3 germ layers in vivo.

MicroRNA-342-3p Inhibits the Proliferation, Migration, and Invasion of Osteosarcoma Cells by Targeting Astrocyte-Elevated Gene-1 (AEG-1).

Recent studies suggest that microRNAs (miRNAs) are critical regulators in many types of cancer, including osteosarcoma. miR-342-3p has emerged as an important cancer-related miRNA in several types of cancers. However, the functional significance of miR-342-3p in osteosarcoma is unknown.