Cost-effectiveness analysis of a community pharmacist-based intervention to prevent cardiovascular complications in patients with type 2 diabetes in Iran.

Background: Evidence suggests that community pharmacist-led interventions in managing type 2 diabetes mellitus (T2DM) can improve clinical outcomes such as glycated hemoglobin (HbA1c), blood pressure, and lipid profiles, thereby reducing the risk of cardiovascular complications. However, limited research has evaluated the economic value of such interventions, particularly in the context of Iran.

Objective: Given the absence of well-designed studies assessing the cost-effectiveness of community pharmacist-based interventions in preventing cardiovascular complications among patients with T2DM in Iran, this study aimed to evaluate the economic and clinical impact of such an intervention.

A review of multimodule stimuli-responsive chitosan-incorporated lipid-based micro/nanocarriers for drug delivery in cancer therapy: Promises, outlooks, and prospects.

Conventional drug delivery systems for cancer therapy have faced various challenges, including side effects and inadequate drug release behavior, which require addressing. Recently, targeted nanocarriers have attracted considerable attention to overcome these challenges. Stimuli-responsive chitosan combined with lipid-based carriers (CLBCs) provides an innovative targeted system that can release its encapsulated drug in response to stimuli, such as pH and temperature, in the tumor site.

Biosynthesis of magnetic ZnO@FeO nanocomposites decorated with Ag/AgCl using Hormoz Island's red soil and Avicennia marina leaf extract.

The development of environmentally sustainable and non-toxic visible-light (VL) sensitive nanostructured photocatalysts is a significant focus in nanotechnology, necessitating safe synthesis techniques for these nanocomposites. This study introduces a straightforward and low-temperature biosynthesis process using leaf extract from the Avicennia marina mangrove (MTLE) and red soil from Hormoz Island, Iran to produce Ag/AgCl-decorated magnetic ZnO@FeO, a plasmonic triple heterojunction nanocomposite (NC). The biosynthesized Ag/AgCl/ZnO@FeO magnetic NC (BSNC) exhibited a particle size of ~ 60 nm, a magnetization of 8.

Post-traumatic Growth in the Link with Resilience, Self-compassion, and the Personal and Clinical Characteristics in Adolescents with Life-threatening Disease: A Cross-sectional Correlational Study.

Background: Post-traumatic growth (PTG) is a significant factor influencing health outcomes. This research aims to determine the status of PTG and its correlation with resilience, self-compassion (SC) and personal and clinical characteristics in adolescents with life-threatening diseases.

Methods: In this cross-sectional correlational study, 200 adolescents with life-threatening disease who were referred to clinics or hospitalized at Shohada Tajrish and children's Medical Center hospitals from June to October 2023 in Tehran, Iran, were selected through convenience sampling.

On how titanium dioxide nanoparticles attenuate the toxicity of mercuric chloride to : investigation of fatty acid composition, oxidative stress, and lipid peroxidation.

Titanium dioxide nanoparticles (TiONPs) as an emerging pollutant in aquatic environments can interact with metals reducing or enhancing their toxicity in these environments. This study examined and compared the toxic effects of mercury ions (Hg ions) on immobilization percentage, fatty acid profile, and oxidative stress of nauplii, individually (Hg) and simultaneously in the presence of 0.10 mg.

Predicting Early recurrence of atrial fibrilation post-catheter ablation using machine learning techniques.

Background: Catheter ablation is a common treatment for atrial fibrillation (AF), but recurrence rates remain variable. Predicting the success of catheter ablation is crucial for patient selection and management. This research seeks to create a machine learning model to forecast the early recurrence of atrial fibrillation following catheter ablation.

Health-Related Quality of Life Among Iranian Women With Uterine Fibroids: A Cross Sectional Study.

Objective: Uterine fibroids (UFs) are the most common benign tumors in women, and their prevalence varies between 5.4 and 77.0% in reproductive-aged women.

The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation.

The precise organization of pre- and postsynaptic terminals is crucial for normal synaptic function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine kinase, postsynaptic TrkC promotes excitatory synapse organization through interaction with presynaptic receptor-type tyrosine phosphatase PTPσ. To isolate the synaptic organizer function of TrkC from its role as a neurotrophin-3 receptor, we generated mice carrying TrkC point mutations that selectively abolish PTPσ binding.

Systemic and Lung Inflammation and Oxidative Stress Associated With Behavioral Changes Induced by Inhaled Paraquat Are Ameliorated by Carvacrol.

Paraquat (PQ) is an herbicide toxin that induces injury in different organs. The anti-inflammatory and antioxidant effects of carvacrol were reported previously. The effects of carvacrol and pioglitazone (Pio) alone and their combination on inhaled PQ-induced systemic and lung oxidative stress and inflammation as well as behavioral changes were examined in rats.

Breast cancer immunotherapy using scFv antibody-based approaches, a systematic review.

Breast cancer is considered as the most common malignancy in women and the second leading cause of death related to cancer. Recombinant DNA technologies accelerated the development of antibody-based cancer therapy, which is effective in a broad range of cancers. The objective of the present study was to perform a systematic review on breast cancer immunotherapy using single-chain fragment variable (scFv) antibody formats.

Drug-resistant oral candidiasis in patients with HIV infection: a systematic review and meta-analysis.

Background: Oral candidiasis (OC) is a prevalent opportunistic infection in patients with human immunodeficiency virus (HIV) infection. The increasing resistance to antifungal agents in HIV-positive individuals suffering from OC raised concerns. Thus, this study aimed to investigate the prevalence of drug-resistant OC in HIV-positive patients.

An overview of pharmacological effects of Crocus sativous and its constituents.

L. was used for the treatment of a wide range of disorders in traditional medicine. Due to the extensive protective and treatment properties of and its constituents in various diseases, the purpose of this review is to collect a summary of its effects, on experimental studies, both and .

Feasibility Study of Convolutional Long ShortTerm Memory Network for Pulmonary Movement Prediction in CT Images.

Background: During X-ray imaging, pulmonary movements can cause many image artifacts. To tackle this issue, several studies, including mathematical algorithms and 2D-3D image registration methods, have been presented. Recently, the application of deep artificial neural networks has been considered for image generation and prediction.

Ionic and nanoparticulate silver alleviate the toxicity of inorganic mercury in marine microalga Chaetoceros muelleri.

Toxicological effects of silver nanoparticles (SNPs) in different organisms have been studied; however, interactions of SNPs with other environmental pollutants such as mercury are poorly understood. Herein, bioassay tests were performed according to ΟECD 201 guideline to assess the toxic effects induced by mercury ions (mercury chloride, MCl) on the marine microalga Chaetoceros muelleri in the presence of SNPs or silver ions (silver nitrate, SN). Acute toxicity tests displayed that the presence of SNPs or SN (0.

Toxicological Impacts of TiO Nanoparticles on Growth, Photosynthesis Pigments, and Protein and Lipid Content of the Marine Microalga Tetraselmis Suecica.

Regarding the widespread use of titanium dioxide nanoparticles (TiONPs) in industry, many concerns have been raised about the risks of their potential release into aquatic ecosystems. Among the marine primary producers, Tetraselmis suecica is an ecologically important microalgae species used also as live feed in the shrimp culture industry. In the present study, the impacts of TiONPs on growth performance, photosynthetic pigments, lipid and protein content and its interaction with the cells of T.

Current status of nano-vaccinology in veterinary medicine science.

Vaccination programmes provide a safe, effective and cost-efficient strategy for maintaining population health. In veterinary medicine, vaccination not only reduces disease within animal populations but also serves to enhance public health by targeting zoonoses. Nevertheless, for many pathogens, an effective vaccine remains elusive.

Neurostimulation as a Putative Method for the Treatment of Drug-resistant Epilepsy in Patient and Animal Models of Epilepsy.

A patient with epilepsy was shown to have neurobiological, psychological, cognitive, and social issues as a result of recurring seizures, which is regarded as a chronic brain disease. However, despite numerous drug treatments, approximately, 30%-40% of all patients are resistant to antiepileptic drugs. Therefore, newer therapeutic modalities are introduced into clinical practice which involve neurostimulation and direct stimulation of the brain.

High and Low-Frequency Stimulation Effect on Epileptiform Activity in Brain Slices.

Background: Neurostimulation is one of the new therapeutic approaches in patients with drug-resistant epilepsy, and despite its high efficiency, its mechanism of action is still unclear. On the one hand, electrical stimulation in the human brain is immoral; on the other hand, the creation of the epilepsy model in laboratory animals affects the entire brain network. As a result, one of the ways to achieve the neurostimulation mechanism is to use epileptiform activity models In vitro.

MiR-548 K regulatory effect on the ABCG2 gene expression in MDR breast cancer cells.

Background: multidrug resistance (MDR) is One of the foremost challenges in overcoming breast cancer. Various molecular processes are involved in the development of MDR in breast cancer cells, including over expression of ABC transporters such as ABCG2 (BCRP), increase breast cancer stem cells drug resistance, and epithelial mesenchymal transition.

Aims: In the present study, we used bioinformatics and experimental analysis to investigate the role of miR-548 K, in the modulating of ABCG2, in MDR breast cancer cells.

Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications.

Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development during which epithelial cells acquire mesenchymal characteristics, and the underlying mechanisms confer malignant features to carcinoma cells such as dissemination throughout the organism and resistance to anticancer treatments. During the past decades, an entire class of molecules, called non-coding RNA (ncRNA), has been characterized as a key regulator of almost every cellular process, including EMT. Like protein-coding genes, ncRNAs can be deregulated in cancer, acting as oncogenes or tumor suppressors.

A Review of Recent Advances in Natural Polymer-Based Scaffolds for Musculoskeletal Tissue Engineering.

The musculoskeletal (MS) system consists of bone, cartilage, tendon, ligament, and skeletal muscle, which forms the basic framework of the human body. This system plays a vital role in appropriate body functions, including movement, the protection of internal organs, support, hematopoiesis, and postural stability. Therefore, it is understandable that the damage or loss of MS tissues significantly reduces the quality of life and limits mobility.

Anti-inflammatory, anti-oxidant, and immunomodulatory activities of the genus and their constituents: A review.

is a genus of the family and it includes around 170 species of flowering plants mostly native to the Mediterranean region and eastern to central Asia. In Iran, spp. are widely used in cuisine and traditional medicine.

Toxicity of TiO nanoparticles to the marine microalga Chaetoceros muelleri Lemmermann, 1898 under long-term exposure.

Titanium dioxide nanoparticles (TiONPs) have been extensively used in industry, raising many concerns about their release into the aquatic environments. In marine ecosystems, microalgae are major primary producers; among them, Chaetoceros muelleri is an important microalga in the aquaculture industry as live feed. The impacts of TiONPs on the growth, photosynthetic pigments, protein and lipid contents, and the interaction of TiONPs with the cell wall of C.

ESRG, LINC00518 and PWRN1 are newly-identified deregulated lncRNAs in colorectal cancer.

Colorectal cancer is the 2nd leading cause of death in humans because of cancer. This rank of death could be due to the high rate of incidence from one hand, and the lack of sufficient diagnostic and therapeutic approaches from the other hand. Thus, molecular tools have been emerging as the potential biomarker to improve the early diagnosis and therapeutic management that subsequently could lead to the heightened survival rate of colorectal cancer patients.

Group I metabotropic glutamate receptors contribute to the antiepileptic effect of electrical stimulation in hippocampal CA1 pyramidal neurons.

Low-frequency deep brain stimulation (LFS) inhibits neuronal hyperexcitability during epilepsy. Accordingly, the use of LFS as a treatment method for patients with drug-resistant epilepsy has been proposed. However, the LFS antiepileptic mechanisms are not fully understood.