Pd, S co-modified Prussian blue analogues nanocomposites for MRI guided combined mitochondria-targeting cancer therapy with tumor microenvironment remodeling, multienzyme-like catalysis and mild photothermal therapeutic effect.

Developing appropriate nanoplatforms with enhanced properties to increase the efficiency of the nano-based strategies is an urgent challenge for cancer therapy. In this work, a S, Pd modified hollow CoNiMnFe Prussian blue analogue nanocomposite (Pd-S-CNMF) was prepared as multifunctional nanoplatform for magnetic resonance imaging (MRI) guided for combined cascade catalyzed therapy and low-temperature photothermal therapy. We found that the co-modification of S and Pd on CNMF could enhance the responsive feature the as-prepared nanocomposite to acidic environment, which endowed the Pd-S-CNMF with multiple enzyme mimicking activities and enhanced NIR light absorption.

DNA self-assembled FeNC nanocatalytic network for ultrasensitive electrochemical detection of microRNA.

Accurate detection of microRNA (miRNA) is challenging but essential for disease diagnostics and therapeutics. To meet the high demands of miRNA analysis, we proposed a highly sensitive and specific electrochemical strategy based on duplex-specific nuclease (DSN)-assisted target recycling and DNA self-assembled FeNC nanocatalytic network for precise quantitation of miRNA-21 as a model. FeNC nanospherical catalyst with high peroxidase-mimicking activity was synthesized through high-temperature pyrolysis and modified with DNA.

Site-specific Umpolung amidation of carboxylic acids via triplet synergistic catalysis.

Development of catalytic amide bond-forming methods is important because they could potentially address the existing limitations of classical methods using superstoichiometric activating reagents. In this paper, we disclose an Umpolung amidation reaction of carboxylic acids with nitroarenes and nitroalkanes enabled by the triplet synergistic catalysis of FeI, P(V)/P(III) and photoredox catalysis, which avoids the production of byproducts from stoichiometric coupling reagents. A wide range of carboxylic acids, including aliphatic, aromatic and alkenyl acids participate smoothly in such reactions, generating structurally diverse amides in good yields (86 examples, up to 97% yield).

A highly selective decarboxylative deuteration of carboxylic acids.

In this paper, we report a mild and practical method for precise deuteration of aliphatic carboxylic acids by synergistic photoredox and HAT catalysis. The reaction delivers excellent D-incorporation (up to 99%) at predicted sites even in substrates bearing reactive C-H bonds or versatile functional groups. The use of a recirculation reactor with a peristaltic pump supports a scalable preparative ability (up to 50 mmol) under very mild reaction conditions.

Oxidative dual C-H thiolation of imidazopyridines with ethers or alkanes using elemental sulphur.

Dual C-H thiolation reactions using elemental sulphur remain a challenge. This communication discloses an oxidative radical dual sp/sp C-H thiolation strategy for the coupling of imidazopyridines with ethers or alkanes using elemental sulphur.