Publications by authors named "Yujin Baek"
Skin aging causes reduced hydration, elasticity, and increased wrinkles. Recent safety and compliance concerns over oral collagen supplements have increased interest in plant-based alternatives like with antioxidant and anti-aging properties. However, clinical evidence regarding its efficacy remains limited.
View Article and Find Full Text PDFHydrogen Bond-Assisted PCET and Formation of W─OH in Bis(Dithiolene) Complex.
Angew Chem Int Ed Engl
July 2025
The redox non-innocent nature of dithiolene ligands is well known for stabilizing high-valent metal ions and facilitating proton-coupled electron transfer (PCET) processes. Until now, proton reactivity at the dithiolene site has been primarily associated with low-valent metal centers, as high-valent metal-dithiolene complexes were not considered viable for such reactivity. This study introduces high-valent bis(dithiolene) tungsten (W)-oxo complexes featuring hydrogen-bonding interactions, unveiling a novel proton reduction mechanism mediated by the dithiolene moiety.
View Article and Find Full Text PDFCytotoxic chemotherapy that kills cancer cells can also elicit antitumor immune responses. Therefore, understanding the immunogenic context of cytotoxic chemotherapy can improve combination immunotherapies. In this study, we sought to improve our understanding of dendritic cell (DC) dynamics in cytotoxic chemotherapy-treated tumor tissues by developing three-dimensional (3D) microfluidic devices that enable high-resolution visualization of cellular dynamics.
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- Lipid-coated microbubbles are commonly used for ultrasound imaging and drug delivery, but their effectiveness is limited by their short lifespan in the bloodstream and challenges with targeting specific cells.
- This study introduces exosome-fused microbubbles (Exo-MBs), which combine microbubbles with exosome membrane proteins, enhancing stability and targeting ability.
- Exo-MBs can then transform into nanoparticles (Exo-NPs) under ultrasound, allowing for improved therapeutic delivery of chlorin e6, leading to increased effectiveness in cancer treatments via photodynamic therapy and immunotherapy.
Gold Nanoparticle-Carrying T Cells for the Combined Immuno-Photothermal Therapy.
Small
November 2023
Article Synopsis
- Cancer immunotherapy shows promise for treating cancer with low toxicity, but many patients don't respond effectively to it alone.
- This study explores a combination treatment using adoptive cell therapy (ACT) with photothermal therapy (PTT), employing smart gold nanoparticles (sAuNPs) to enhance the effectiveness of T cells against tumors.
- The results indicate that while the T cells can infiltrate tumors and initially control growth, the tumors eventually regrow; thus, combining ACT with PTT leads to significantly better outcomes compared to using either treatment on its own.
activation of dendritic cells coacervate-mediated exogenous tumor cell lysate delivery.
Biomater Sci
June 2023
For the successful development of various cellular products in cancer immunotherapy, an effective priming technique for immune cells is often required. Among a variety of immunomodulatory substances, tumor cell lysates (TCLs) have been considered a robust immune activator with high adjuvanticity and tumor antigen population. Therefore, the present study suggests a novel dendritic cell (DC) priming technique that utilizes (1) squaric acid (SqA)-mediated oxidation of source tumor cells to obtain antigenic TCLs with an increased immunogenic potential and (2) a coacervate (Coa) colloidal complex as an exogenous TCL carrier.
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- The study presents an innovative implantable ionic device designed to deliver targeted light directly to tumor tissues, overcoming the limitations of external light sources that have low penetration.
- The device incorporates a wireless power transfer system to eliminate the need for battery replacements, ensuring stable light delivery while preventing mechanical inconsistencies often found in traditional systems.
- Testing showed that the device enhances antitumor effects effectively compared to conventional light treatments, demonstrating its potential for long-term exposure and clinical applications in managing residual tumors.
Natural killer (NK) cells are a subset of innate lymphoid cells playing an important role in immune surveillance and early defense against infection and cancer. They recognize and directly kill infected or transformed cells. At the same time, they produce various cytokines and chemokines to regulate other immune cells.
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