Effects of total urethral suspension combined with posterior pelvic floor reconstruction on sexual function in women with stress urinary incontinence and concomitant vaginal laxity syndrome.

Objective: To assess the impact of total urethral suspension with posterior pelvic floor reconstruction on sexual function in women with stress urinary incontinence(SUI) and concomitant vaginal laxity syndrome (VLS), including partner satisfaction.

Methods: Clinical data from 150 pelvic floor dysfunction patients were collected at the First Affiliated Hospital of Kunming Medical University (March 2023-March 2024). Preoperative assessments included demographics, obstetric/surgical history, menopausal status, sexual activity and .

The Progress in Exploratory Studies of Peripheral Blood Single Nucleated Cells as Seed Cells in Peripheral Nerve Repair.

Peripheral nerve injury (PNI) represents a prevalent clinical condition, often resulting from mechanical trauma or tumor resection, which frequently induces persistent sensory deficits, motor impairment, neuropathic pain, or paralysis. Consequently, substantial socioeconomic burdens are imposed on affected individuals. Autologous nerve transplantation is often considered the preferred approach for reconstructing peripheral nerve defects; however, this technique is associated with limitations including donor-site sensory loss, restricted graft length, and nerve mismatches.

Extramammary Paget's Disease of the Scrotal and Penile: A Case Report and Review of the Literature.

Introduction: Extramammary Paget's disease of the scrotum and penis is a relatively rare cutaneous malignant tumor. At present, its pathogenesis, and clinical and pathological characteristics are not very clear. This is controversial regarding surgical margin width to decrease the high recurrence rate.

A Comparative Study on the Clinical Efficacy of Simple Transobturator Midurethal Sling and Posterior Pelvic Floor Reconstruction.

The purpose of this study was to compare the complications, success rate and satisfaction of pelvic floor reconstruction after transobturator midurethral sling (TOT) and TOT combined with pelvic floor reconstruction in the treatment of female stress urinary incontinence. To explore the pathogenesis of stress urinary incontinence after pelvic floor stress injury and improve the surgical treatment strategy. From 15 August 2018 to 24 February 2022, patients diagnosed with stress urinary incontinence (SUI) and secondary prolapse of the anterior pelvis were selected to receive surgically.

Continuous hypergammaglobulinemia and proteinuria after the recovery of the visceral Leishmaniasis: a case report.

Background: Kidney involvement of visceral Leishmaniasis is previously reported, but knowledge is limited. Hypergammaglobulinemia is common in visceral leishmaniasis patients. Whether hypergammaglobulinemia after leishmaniasis depletion can cause kidney injury is not well reported yet.

The effect of A1 adenosine receptor in diabetic megalin loss with caspase-1/IL18 signaling.

Purpose: In our previous study, exacerbation of albuminuria was observed in A1 adenosine receptor knockout (A1AR) mice with diabetic nephropathy (DN), but the mechanism was unclear. Here, we investigated the relationship of megalin loss and albuminuria, to identify the protective effect of A1AR in megalin loss associated albuminuria by inhibiting pyroptosis-related caspase-1/IL-18 signaling of DN.

Methods: We successfully collected DN patients' samples and built diabetes mice models induced by streptozotocin.

Clinicopathological analysis of 155 patients with persistent isolated hematuria.

Objectives: To reveal etiologies of persistent isolated hematuria (PIH) through ultrastructural pathological examination, to disclose clinicopathological correlation in cases with PIH, and to summarize appropriate management of patients with PIH.

Methods: we retrospectively studied 155 PIH patients receiving renal biopsy between January, 2003 and December, 2008 in Peking Union Medical College Hospital. All the clinical data and follow-up result were analyzed.

Rapidly progressive glomerulonephritis due to anti-glomerular basement membrane disease accompanied by IgA nephropathy: a case report.

Anti-glomerular basement membrane (anti-GBM) disease is characterized by autoantibodies against antigenic site on type IV collagen of the GBM. The coexistence of anti-GBM disease and other immune complex mediated glomerulonephritis is common. Herein, we describe a patient presented with rapidly progressive glomerulonephritis, who was diagnosed as IgA-mediated nephropathy and was found to have abundant serum anti-glomerular basement membrane IgG antibodies.