Exploring the mechanism of Danshen in treating Kawasaki disease through network pharmacology and molecular docking approaches.

This study aims to identify the primary active components of Danshen (Salvia miltiorrhiza) and explore the potential mechanisms underlying its therapeutic effect on Kawasaki disease (KD). Active components of Danshen and their action targets were screened using traditional Chinese medicine systems pharmacology and SwissTargetPrediction databases. KD-related targets were retrieved from Online Mendelian Inheritance in Man, Pharmacogenomics Knowledge Base, and GeneCards databases.

A population-based analyses of the evolving management of cN1M0 prostate cancer in the PSMA-PET era.

Objectives: To evaluate the patterns of management of clinical node-positive non-metastatic prostate cancer (cN1M0PC) at a population-based level over time, and to identify factors associated with the different management approaches.

Patients And Methods: The study included men diagnosed with cN1M0PC in Prostate Cancer Outcome Registry Victoria (PCOR-Vic) in Australia between 2008 and 2022. The primary outcome was the use of local therapy (radical prostatectomy or prostate+/- pelvic radiation therapy) within the first 12 months of diagnosis.

Midwives' experiences in the clinical management of oxytocin infusion for labor induction and augmentation: a qualitative study.

Background: Midwives play a central role in administering oxytocin for labor induction and augmentation. Understanding their experiences with oxytocin management can provide valuable insights for refining administration protocols and improving clinical outcomes.

Methods: This exploratory qualitative study, guided by a descriptive phenomenological approach, employed semi-structured interviews to explore midwives' experiences with oxytocin infusion for labor induction and augmentation.

Exploring attentional bias in nursing students under sadness priming: A dot-probe study.

This study aims to examine how sadness primed in nursing students, influences attentional bias using the dot-probe task. Sixty nursing students who have experienced patient deaths were randomly assigned to either a sadness priming group or a control group in a dot-probe study. Results indicated that, under emotional priming, the sadness priming group had longer reaction times to sad faces in the inconsistent condition compared to the consistent condition ( = 0.

Circular RNA pappalysin-1 enhances glycolysis via microRNA-656-3p targeting G-protein subunit gamma-5 to promote colon cancer progression.

Background And Objective: Colon Cancer (CC) is a common malignant tumor. The aim of this study was to investigate the role and regulatory mechanism of circular RNA pappalysin-1 (circ-PAPPA; hsa_circ_0088233) in CC.

Methods: In cancer tissues from CC patients, circ-PAPPA expression was measured and its relationship with patients' clinical features was analyzed.

Sebaceous Carcinoma in the Right Inguinal Region with Multiple Metastases and a Poor Prognosis: A Case Report.

Introduction: Sebaceous carcinoma (SC) is a rare malignancy and can be divided into two types, ocular and extra-ocular SC. Extra-ocular SC is typically associated with a better prognosis than ocular SC. However, extra-ocular SCs located in atypical areas, such as the inguinal region, along with multiple metastases, are uncommon and present significant challenges, often leading to poorer outcomes.

Prevalence and risk factors of cognitive frailty among pre-frail and frail older adults in nursing homes.

Background: The purpose of this research was to stratify the level of frailty to examine the risk factors associated with reversible cognitive frailty (RCF) and potentially reversible cognitive frailty (PRCF) in nursing homes to provide a basis for hierarchical management in different stages of frailty.

Methods: The study was a cross-sectional study conducted from September to November 2022; 504 people were selected by stratified random sampling after convenience selection from the Home for the Aged Guangzhou. The structured questionnaire survey was conducted through face-to-face interviews using the general data questionnaire, Fried Frailty Phenotype, Montreal Cognitive Assessment Scale.

Pathologic Complete Response and Oncologic Outcomes in Locally Advanced Breast Cancers Treated With Neoadjuvant Radiation Therapy: An Australian Perspective.

Purpose: To assess the degree of pathologic complete response (pCR), postoperative surgical complication rates, and oncological outcomes in women with locally advanced breast cancer or high-risk breast cancers treated with neoadjuvant radiation therapy (NART).

Methods And Materials: This retrospective, multi-institutional review involved 138 clinically staged patients with 140 breast cancers treated with NART between January 2014 and February 2021. Treatments involved sequential neoadjuvant chemotherapy and NART, followed by mastectomy with or without axillary surgery and immediate autologous breast reconstruction.

Incidence and Predictors of Cardiac Implantable Electronic Devices Malfunction with Radiotherapy Treatment.

Aims: To investigate the incidence of cardiac implantable electronic devices (CIED) malfunction with radiotherapy (RT) treatment and assess predictors of CIED malfunction.

Methods: A 6-year retrospective analysis of patients who underwent RT with CIED identified through the radiation oncology electronic database. Clinical, RT (cumulative dose, dose per fraction, beam energy, beam energy dose, and anatomical area of RT) and CIED details (type, manufacturer, and device malfunction) were collected from electronic medical records.

Impact of hydrogel and hyaluronic acid rectal spacer on rectal dosimetry and toxicity in low-dose-rate prostate brachytherapy: a multi-institutional analysis of patients' outcomes.

Purpose: To report on rectal dosimetry and toxicity outcomes in men with prostate cancer (PCa) treated with iodine-125 low-dose-rate brachytherapy (LDR-BT) with or without polyethylene glycol hydrogel (HS) or hyaluronic acid (HA) rectal spacer (RS) insertion.

Material And Methods: Seventy consecutive men treated with LDR-BT between December 2017 and July 2019 were included in this study, including twenty-eight (40%) men who had RS insertion according to the preference of referring urologist, compared to a group of forty-two men (60%) without RS. Descriptive statistics were used to compare RS safety, dosimetric effects on organs at risk (rectum and urethra), and gastrointestinal (GI) and genitourinary toxicities (GU) (assessed using the CTCAE v.

Current clinical practice in patients with cardiac implantable electronic devices undergoing radiotherapy: a literature review.

Patients with cardiac implantable electronic devices (CIED) undergoing radiotherapy (RT) are more common due to the ageing of the population. With newer CIEDs' implementing the complementary metal-oxide semiconductor (CMOS) technology which allows the miniaturization of CIED, it is also more susceptible to RT. Effects of RT on CIED ranges from device interference, device operational/memory errors of permanent damage.

Phantom simulation of liver metastasis on a positron emission tomography with computed tomography scan after neoadjuvant chemoradiotherapy for distal esophageal cancer: a case report.

Background: Neoadjuvant chemoradiotherapy is currently the gold standard treatment for esophageal cancer prior to surgery. This radiation therapy will sometimes lead to liver damage parallel to esophageal lesions, which mimics liver metastasis visualized by F-fluorodeoxyglucose positron emission tomography with computed tomography. In this report, we publish virtual radiation-induced liver damage images obtained during surgery, along with the coherent pathology, in order to confirm the false-positive result through an optimally decisive radiological examination.

Down-regulation of LncRNA CCAT1 enhances radiosensitivity via regulating miR-148b in breast cancer.

LncRNA colon-cancer-associated transcript-1 (CCAT1) was proved to be a potential prognostic biomarker for breast cancer progression. However, the role of CCAT1 in regulating radiosensitivity of breast cancer and its underlying mechanism have not been investigated. The present study showed that CCAT1 was up-regulated and miR-148b was down-regulated in radioresistant breast cancer tissues compared with radiosensitive breast cancer tissues.