Entanglement of spin transition and structural adaptability: manipulating the slow spin equilibrium by the guest-mediated fine-tuning of elastic frustration.

A comprehensive analysis of physical and chemical properties using the same family of spin-crossover complexes is crucial for understanding and designing structure-property relationships. However, finding an appropriate system remains challenging. Here, a series of guest-saturated states based on the 2D Hofmann-type framework [Fe(prentrz)Pd(CN)]·guest (prentrz = (1,2)-3-phenyl--(4-1,2,4-triazol-4-yl)prop-2-en-1-imine; 1·guest) is reported, exhibiting a guest-manipulated slow dynamic effect on spin equilibrium in an incomplete two-step spin-crossover (SCO) process.

Unsupervised SAM segmentation of zebrafish body: Application to melanin analysis.

Zebrafish have always been a valuable model for studies on human health. Their transparency makes it highly suitable for observing melanin synthesis. Moreover, their high genetic similarity to humans facilitates the study of human diseases, including pigmentation disorders.

Dual role of oxygen vacancies in TiO/BiO for enhanced carrier separation and PDS activation: A combined experimental and DFT study.

A layered solvothermal method to control the distribution of oxygen vacancies (O) in TiO-O/BiO was proposed. This composite was used to degrade four typical synthetic organic chemicals, and exhibited excellent degradation efficiency and stability in the photoelectrocatalysis (PEC)/peroxydisulfate (PDS) system. To clarify the mechanism of improving the PEC efficiency of this system, the O inward migration energy barriers, theoretical band gap, and adsorption energy (E) of PDS were simulated by density functional theory (DFT); at the same time, the types and contributions of the main oxidizing species were investigated by quenching experiments.

Explore the effect of HIF-PHI on blood pressure variation rate and anemia efficacy in maintenance hemodialysis patients.

Objective: This study aims to investigate the impact of hypoxia-inducing factor prolyl hydroxylase inhibitor (HIF-PHI), specifically Roxadustat, on blood pressure variability, blood pressure indices, hemoglobin, and other biochemical markers in maintenance hemodialysis (MHD) patients.

Methods: In this retrospective, self-controlled study, regular hemodialysis and consistent use of Roxadustat for at least six months were conducted at the Hemodialysis Unit of the First Affiliated Hospital of Nanchang University between June 2019 and November 2022. The study involved MHD patients who had been using erythropoiesis-stimulating agents (ESAs) for at least six months prior to transitioning to Roxadustat.

Silver doping-induced electrochemiluminescence enhancement of CdTe quantum dots combined with hairpin-fueled entropy-driven reactions strategy for ultrasensitive bioanalysis.

Herein, silver-doped cadmium telluride quantum dots (Ag-CdTe QDs) as electrochemiluminescence (ECL) emitter with intense ECL signal and hairpin-fueled entropy-driven reactions (H-EDR) as signal amplifier with high conversion efficiency and low signal leakage were exploited to construct an ECL biosensor for ultrasensitive determination of microRNA 222 (miRNA-222) related to liver cancer. Interestingly, the ECL intensity of Ag-CdTe QDs has been improved by 2.5 times compared to that of undoped CdTe QDs for improving the detection sensitivity, which attributed to the crystal shape transformation of Ag-CdTe QDs through silver doping for the reduction of band gap to change the electron-hole recombination path.

Monitoring the Growth and Habitat Shifts of Epiphyllous Liverworts in Subtropical Forests of China.

Understanding the extent to which species can adjust their ranges in response to climate change and track areas of suitable climatic conditions is vital for conservation efforts. Nonetheless, the observed changes in species distribution may also result from inadequate field data. This is particularly relevant for epiphyllous liverworts, which exhibit a poikilohydric lifestyle that makes them more vulnerable to climatic fluctuations than many other higher plants.

[Effects of Rehmanniae Radix Praeparata on striatal neuronal apoptosis in ADHD rats via Bcl-2/Bax/caspase-3 pathway].

This study investigated the effects of Rehmanniae Radix Praeparata on striatal neuronal apoptosis in rats with attention deficit hyperactivity disorder(ADHD) based on the B-cell lymphoma-2(Bcl-2)/Bcl-2-associated X protein(Bax)/caspase-3 signaling pathway. Twenty-four 3-week-old male spontaneously hypertensive rats(SHR) were randomly divided into a model group, a methylphenidate group(2 mg·kg~(-1)·d~(-1)), and a Rehmanniae Radix Praeparata group(2.4 mg·kg~(-1)·d~(-1)).

The bidirectional association between hemorrhoidal disease and varicose veins: a nationwide population-based cohort study.

Purpose: Hemorrhoidal disease (HD) and varicose veins (VV) are both common diseases. The aim was to investigate the association between them.

Methods: A nationwide cohort study was conducted using the Taiwan National Health Insurance Research Database (NHIRD) from 2005 to 2021, which included information of over 31 million beneficiaries.

Excessive screen time and problem behaviours among school-age children in Fujian, China: a cross-sectional study.

Background: Screen time encompasses activities conducted on digital devices, including traditional devices such as televisions and computers, as well as modern devices like smartphones, tablets, and other digital screens. Excessive screen time among children has been linked to a heightened likelihood of engaging in high-risk problem behaviours. This study aimed to quantify the prevalence of excessive screen time and delve into its correlation with problem behaviours among school-aged children in Fujian, thereby gaining insight into the prevalence and trends within this region.

Collagenases from hepatopancreas and muscle of Litopenaeus vannamei: Purification, characterization and comparison of their behaviors in collagen degradation.

Collagenases are responsible for collagen degradation, resulting in shrimp muscle softening after death. In this study, biochemical characteristics of collagenases purified from hepatopancreas (CPH) and muscle (CPM) of Litopenaeus vannamei were comparatively investigated. Changes of enzyme activity in shrimp hepatopancreas and muscle presented totally different tendencies, which decreased and increased respectively.

Prediction and mechanism of combined toxicity of surfactants and antibiotics in aquatic environment based on in silico method.

The coexistence of surfactants and antibiotics in aquatic environments can potentially trigger combined toxic effects on aquatic organisms. Unfortunately, the effects of these joint toxins and the corresponding mechanism remain unclear. In this study, we performed individual and combined toxicity experiments involving surfactants and antibiotics.

Predictive model in silicon and pathogenicity mechanism of metabolic syndrome: Impacts of heavy metal exposure.

Although the association between heavy metals in human and the development of metabolic syndrome (MetS) have been extensively studied, the pathogenic mechanism of MetS affected by metals is not clear to date. In this study, a predictive model was developed with machine learning base on the large-scale dataset. These proposed models were evaluated via comparatively analysis of their accuracy and robustness.

Grain engineering for efficient near-infrared perovskite light-emitting diodes.

Metal halide perovskites show promise for next-generation light-emitting diodes, particularly in the near-infrared range, where they outperform organic and quantum-dot counterparts. However, they still fall short of costly III-V semiconductor devices, which achieve external quantum efficiencies above 30% with high brightness. Among several factors, controlling grain growth and nanoscale morphology is crucial for further enhancing device performance.

Toxicological interactions of cosmetic and personal care additives mixtures: An update based on measurement and simulation.

The toxicity of chemical mixtures may be misestimated, as the assessment of individual chemicals may not adequately reflect their combined toxic effects. However, numerous combinations of chemicals and various interactions make it impossible to measure all possible mixtures. Computational toxicology can help to mitigate this issue, particularly with new methodologies that rely upon alternatives to animal testing.

Exciton Dynamics in Layered Halide Perovskite Light-Emitting Diodes.

Layered halide perovskites have garnered significant interest due to their exceptional optoelectronic properties and great promises in light-emitting applications. Achieving high-performance perovskite light-emitting diodes (PeLEDs) requires a deep understanding of exciton dynamics in these materials. This review begins with a fundamental overview of the structural and photophysical properties of layered halide perovskites, then delves into the importance of dimensionality control and cascade energy transfer in quasi-2D PeLEDs.

The effect of folate deficiency and different doses of folic acid supplementation on liver diseases.

The liver has multiple functions such as detoxification, metabolism, synthesis and storage. Folate is a water-soluble vitamin B, which participates in one-carbon transfer reactions, maintains methylation capacity and improves oxidative stress. Folic acid is a synthetic form commonly used as a dietary supplement.

Anti-flammable, anti-fouling, anti-bacterial treatment of cotton fabrics with MOF-based hybrid coatings for highly efficient oil-water separation.

A flame-retardant and hydrophobic coating was deposited on the surface of the cotton fabric via a two-step spray deposition technique. Specifically, the coating was composed of flame-retardant component (guanidine phosphate) and hydrophobic components (Ti-MOF and bis(3-aminopropyl)-terminated poly(dimethylsiloxane) (PDMS)) and crosslinked with glutaraldehyde. The limiting oxygen index (LOI) of the coated cotton fabrics increased from 18.

Self-management experiences in fall prevention among community-dwelling older adults in China: a descriptive qualitative study.

Background: Falls are the most common injuries in older adults, and fall prevention is one of the primary measures to achieve healthy aging. Self-management refers to the measures taken by individuals to avoid various adverse factors and health damage to protect and promote their health. This study aimed to explore the factors and measures of self-managed fall prevention among community-dwelling older adults.

Aberrant cortical morphology patterns are associated with cognitive impairment in patients with chronic heart failure.

A mounting body of evidences suggests that patients with chronic heart failure (HF) frequently experience cognitive impairments, but the neuroanatomical mechanism underlying these impairments remains elusive. In this retrospective study, 49 chronic HF patients and 49 healthy controls (HCs) underwent brain structural MRI scans and cognitive assessments. Cortical morphology index (cortical thickness, complexity, sulcal depth and gyrification) were evaluated.

Polymerized carbon dots with high electrochemiluminescence efficiency and long wavelength ECL emission for ultrasensitive detection of MicroRNA-222.

Herein, a new electrochemiluminescence (ECL) biosensor was constructed with highly efficient polymerized carbon dots (PCDs) as ECL emitter and the improved localized catalytic hairpin assembly (L-CHA) as signal amplifier for ultrasensitive detection of microRNA-222 (miRNA-222). Impressively, compared to the traditional carbon dots with inefficient blue region ECL emission, PCDs with N, O co-dope and large conjugated π-system showed high electrical conductivity, narrow band gap and strong radiative transition, which could exhibit high ECL efficiency to improve the sensitivity of detection and long wavelength ECL emission to achieve deep tissue penetration for reducing biological damage. Furthermore, the trace target miRNA-222 could be efficiently converted into large amounts of output DNA labelled with the quencher dopamine (S-DA) through the L-CHA reaction to significantly enhance the target amplification efficiency for further improving the sensitivity of detection.

Arenobufagin regulates the p62-Keap1-Nrf2 pathway to induce autophagy-dependent ferroptosis in HepG2 cells.

Hepatocellular carcinoma (HCC) is the most prevalent type of primary liver cancer, accounting for the overwhelming majority of malignant liver tumors. Therefore, how to effectively prevent and cure HCC has become a research hotspot. Many studies have shown that arenobufagin can induce apoptosis, ferroptosis, and autophagy of tumor cells.