Publications by authors named "Yoshifumi Mizuguchi"
Objective: In patients with chronic limb-threatening ischemia (CLTI), the Global Limb Anatomical Staging System (GLASS) P2 modifier, defined by the absence of a target artery crossing the ankle and lack of a suitable pedal or plantar artery, indicates a no-option anatomic pattern. Although several studies have reported successful endovascular therapy (EVT) in such patients, EVT outcome predictors in this high-risk population remain unclear. This study aimed to identify factors contributing to procedural failure in patients with the GLASS P2 modifier undergoing EVT.
View Article and Find Full Text PDFBackground: There are little data on clinically meaningful heart failure (HF) phenogroups, which are associated with treatment response across the wide spectrum of left ventricular (LV) ejection fraction.
Objectives: The authors aimed to identify the phenotypes of patients with HF with different prognoses and responses to medical therapies.
Methods: We examined consecutive 2,301 chronic HF patients from the ELMSTAT-HF (EpidemioLogical Multicenter Study for Tailored Treatment in Heart Failure) registry, a prospective multicenter cohort in which 2,317 patients were enrolled between January 2020 and September 2024.
Purpose: To evaluate the effect of hemodialysis (HD) in a medical history of patients with inframalleolar (IM) occlusive disease following balloon angioplasty for de novo occluded IM lesions, specifically focusing on the clinical outcomes related to their HD history.
Materials And Methods: The study had a multicenter, retrospective, nonrandomized, observational design and was performed at 4 cardiovascular centers in Japan. Patients aged ≥20 years with chronic limb-threatening ischemia (CLTI) (Rutherford Classification 5-6) who were treated with endovascular therapy for de novo IM occlusions between January 2016 and December 2022 were included.
Acute coronary syndrome (ACS) requires rapid transportation by the emergency medical system (EMS). In snowy areas, traffic conditions may delay EMS transport times and increase mortality rate of ACS. However, there is a paucity of systemic data showing how snowfall affects the EMS and mortality in patients with ACS.
View Article and Find Full Text PDFBackground: Anemia is frequently observed and associated with mortality in patients with heart failure (HF). Although the quality of erythropoiesis is an intrinsic aspect of anemia's pathophysiology, its prognostic value in HF patients is unclear.
Methods: Between January 2020 and October 2023, 1328 symptomatic patients with chronic HF from a multicentre registry were prospectively examined.
Usefulness of frailty assessment using the revised Japanese version of the Cardiovascular Health Study on the prediction of clinical outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement.
Cardiovasc Interv Ther
January 2025
Article Synopsis
- Frailty assessment is important for determining treatment strategies in patients with aortic stenosis (AS) who are undergoing transcatheter aortic valve replacement (TAVR), and the revised Japanese Cardiovascular Health Study (J-CHS) criteria is being tested for its effectiveness.
- A study involving 205 severe AS patients revealed that 51% were classified as frail using the revised J-CHS criteria, which indicated a significant association with major adverse cardiac or cerebrovascular events (MACCE) during follow-up.
- The findings suggest that frailty evaluated by the revised J-CHS criteria can help predict clinical outcomes and may be a useful tool for risk stratification in Japanese patients with AS undergoing TAVR.
Article Synopsis
- - This study examined how self-care behaviors affect mortality in chronic heart failure (CHF) patients, focusing on those with and without recent hospitalizations for heart failure.
- - Researchers analyzed data from 1,907 CHF patients in Japan, finding that those with poor self-care (scores < 70 on a self-care scale) were more likely to face death or rehospitalization if they had been recently hospitalized for heart failure.
- - The results suggest that self-care education is crucial for patients who have recently been hospitalized, as it significantly impacts their health outcomes.
Article Synopsis
- The study aimed to evaluate the validity and reliability of the Needs Assessment Tool: Progressive Disease-Heart Failure (NAT: PD-HF) specifically for Japanese patients with heart failure who might require palliative care.!
- It involved 106 patients with chronic heart failure and collected data from their caregivers and healthcare providers, utilizing a translated and culturally adapted version of the tool.!
- Results indicated strong reliability statistics, with a Cronbach's alpha of 0.82, and high user feedback, as most participants found the tool easy to understand and believed it could enhance care quality.!
Machine learning-based gait analysis to predict clinical frailty scale in elderly patients with heart failure.
Eur Heart J Digit Health
March 2024
Article Synopsis
- Researchers aimed to create a machine learning tool to automatically assess frailty in elderly heart failure patients, addressing the inconsistency of subjective frailty scales.
- The study involved 417 patients aged 75 and older, using smartphone technology to analyze body motion and determine frailty scores based on key physical features.
- Results showed that the machine learning model demonstrated strong agreement with actual frailty assessments and that higher frailty scores predicted an increased risk of death over a follow-up period.
Aim: The present study aimed to investigate the impact of mild tricuspid regurgitation (TR) on the exercise capacity or clinical outcomes in patients with chronic heart failure (CHF).
Methods And Results: The study enrolled 511 patients with CHF who underwent cardiopulmonary exercise testing (CPET) between 2013 and 2018. The primary outcome was a composite of heart failure hospitalization and death.
Article Synopsis
- * The study analyzed the relationship between levels of inflammatory biomarkers and coronary plaque characteristics in 30 patients who underwent a procedure called percutaneous coronary intervention (PCI).
- * Findings showed that a higher coronary plaque risk score (CPRS) was significantly associated with TLR and that serum levels of monocyte chemoattractant protein-1 (MCP-1) correlated with CPRS, suggesting it could help identify severe coronary plaque conditions.
Differences in blood flow dynamics between balloon- and self-expandable valves in patients with aortic stenosis undergoing transcatheter aortic valve replacement.
J Cardiovasc Magn Reson
October 2023
Background: The differences in pre- and early post-procedural blood flow dynamics between the two major types of bioprosthetic valves, the balloon-expandable valve (BEV) and self-expandable valve (SEV), in patients with aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR), have not been investigated. We aimed to investigate the differences in blood flow dynamics between the BEV and SEV using four-dimensional flow cardiovascular magnetic resonance (4D flow CMR).
Methods: We prospectively examined 98 consecutive patients with severe AS who underwent TAVR between May 2018 and November 2021 (58 BEV and 40 SEV) after excluding those without CMR because of a contraindication, inadequate imaging from the analyses, or patients' refusal.
Less data are available regarding the impact of cardiac power output on exercise capacity or clinical outcome in patients with chronic heart failure (CHF). The study enrolled 280 consecutive patients with CHF referred for cardiopulmonary exercise testing and right-sided heart catheterization between 2013 and 2018. The primary outcome was composite of heart failure hospitalization or death.
View Article and Find Full Text PDFSeveral liver fibrotic markers are associated with prognosis in patients with heart failure (HF). However, the optimal markers for outcome prediction remain unclear. This study aimed to simultaneously investigate the prognostic value of liver fibrotic markers and the associations between these markers and clinical parameters in patients with HF without organic liver disease.
View Article and Find Full Text PDFThe global coronavirus disease-2019 (COVID-19) pandemic is associated with reduced rate of percutaneous coronary intervention (PCI). However, there were a few data showing how emergency medical system (EMS) and management strategies for acute coronary syndrome (ACS) changed during the pandemic. We sought to clarify changes on characteristics, treatments, and in-hospital mortality of patients with ACS transported via EMS between pre- and post-pandemic.
View Article and Find Full Text PDFThe prognostic impact of peak workload-to-weight ratio (PWR) during cardiopulmonary exercise testing (CPET) and its determinants in patients with chronic heart failure (CHF) are not well understood. Consecutive 514 patients with CHF referred for CPET at the Hokkaido University Hospital between 2013 and 2018 were identified. The primary outcome was a composite of hospitalization because of worsening heart failure and death.
View Article and Find Full Text PDFImpact of right ventricular reserve on exercise capacity and quality of life in patients with left ventricular assist device.
Am J Physiol Heart Circ Physiol
March 2023
Article Synopsis
- Measuring right ventricular (RV) function during exercise provides more insights than resting measurements, particularly in patients using left ventricular assist devices (LVAD).
- The study aimed to determine the correlation between changes in RV stroke work index (ΔRVSWI) during exercise and both exercise capacity and health-related quality of life (HRQoL).
- Results indicated that higher ΔRVSWI correlated positively with better exercise performance (measured by 6-minute walk distance and peak oxygen consumption) and improved HRQoL, suggesting its importance for risk assessment in LVAD patients.
Article Synopsis
- The study investigates the applicability of new iron deficiency (ID) criteria in Japanese patients with heart failure (HF), shifting focus from previously established guidelines.
- Out of 763 chronic HF patients, 28% met the new criteria while 58% met the guideline criteria, with the study finding no significant difference in all-cause mortality between those who met the guideline ID criteria and those who didn't.
- However, the proposed criteria were linked to higher mortality risk, indicating that they may be more applicable and beneficial for assessing ID in the Japanese HF population.
Objectives: Evaluation of liver stiffness (LS) by magnetic resonance elastography (MRE) is useful for estimating right atrial pressure (RAP) in patients with heart failure (HF). However, its prognostic implications are unclear. We sought to investigate whether LS measured by MRE (LS-MRE) could predict clinical outcomes in patients with HF.
View Article and Find Full Text PDFBackground: Cardiac power output is a measure of cardiac performance, and its prognostic significance has been shown in heart failure (HF) with reduced ejection fraction. Patients with HF with preserved ejection fraction may have altered cardiac performance, but the prognostic relevance of cardiac power output is unknown. This study sought to determine the association between cardiac power output and clinical outcomes in HF with preserved ejection fraction and to compare its prognostic effect to other measures of cardiac performance including ventricular-arterial coupling and mechanical efficiency.
View Article and Find Full Text PDFErratum to: Pseudo-cardiac tamponade owing to a large hiatal hernia.
Oxf Med Case Reports
December 2021
[This corrects the article DOI: 10.1093/omcr/omab090.].
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