Isolated renal pelvis rupture due to blunt trauma presenting with low-density fluid accumulation around kidney on initial CT: A case report.

Back Ground: Renal pelvis rupture due to trauma is commonly diagnosed in an excretory phase CT scan, which is not be applied in substantial proportion of trauma patients during initial evaluation. Since renal pelvis rupture has no specific findings, there is no clear indication to perform an excretory phase CT scan in the evaluation of trauma patients. We experienced a case presented with low-density fluid accumulation around kidney on plain CT imaging, subsequently diagnoses as having isolated renal pelvis injury.

Course of Multimodal Therapy and Genetic Profile of Hereditary Leiomyomatosis and Renal Cell Carcinoma with Early Recurrence during Adjuvant Therapy after Radical Nephrectomy: A Case Report.

Introduction: Fumarate hydratase-deficient renal cell carcinoma is a rare and aggressive subtype associated with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome, characterized by germline mutations in the fumarate hydratase (FH) gene. Here, we report a case of HLRCC with early recurrence during adjuvant therapy following radical nephrectomy.

Case Presentation: A 34-year-old woman with FH-deficient RCC presented with fever, right flank pain, and a large renal mass with a tumor thrombus.

Trends in the use and efficacy of adjuvant immunotherapy in muscle-invasive urothelial carcinoma.

We investigated trends in the use of perioperative therapy and the efficacy of adjuvant immunotherapy on the prognosis of patients with muscle-invasive urothelial carcinoma (MIUC). The usage and trends in neoadjuvant and adjuvant therapy were examined, and the efficacy of adjuvant immunotherapy was assessed using propensity score-adjusted Cox multivariate analysis. We investigated 1383 patients with muscle-invasive bladder cancer and 1124 patients with upper tract urothelial carcinoma; 1095 (43.

Immune-Related Fulminant Myocarditis Revealed Using Myocardial Histopathology at Autopsy in the Treatment of Advanced Renal Cell Carcinoma: A Case Report.

Introduction: Although immune checkpoint inhibitor-associated myocarditis is relatively rare, it has the highest mortality rate among all immune-related adverse events, at 30-50%.

Case Presentation: We encountered a case of advanced renal cancer in which immune checkpoint inhibitor-associated myocarditis was confirmed on autopsy. A 78-year-old man was diagnosed with a left renal tumor secondary to hematuria.

Enfortumab Vedotin-Induced Diabetic Ketoacidosis and Acute Tubulointerstitial Nephritis Requiring Intensive Care in the Treatment of Advanced Urothelial Carcinoma: A Case Report.

Introduction: Enfortumab vedotin (EV) has been approved for the treatment of many types of cancer, and its use is still expanding. It is an essential drug used as a standard treatment for advanced and metastatic urothelial carcinoma but is known to cause various adverse events (AEs).

Case Presentation: We report a patient with metastatic urothelial carcinoma who experienced multiple AEs associated with diabetic ketoacidosis (DKA) during EV treatment.

Fulminant lymphocytic myocarditis with unusual giant cell detection: a case report.

Background: An accurate and rapid pathologic diagnostic in fulminant myocarditis is crucial for appropriate therapeutic decision-making. Since giant cells can appear in various conditions, careful judgment based on repeated imaging, pathological analysis, and close clinical follow-up is essential to make precise decisions.

Case Summary: A previously healthy 36-year-old woman was admitted to the hospital with haemodynamic compromise requiring mechanical circulatory support.

Impact of right ventricular reserve function during exercise on aortic valve opening in patients with left ventricular assist device.

Background: Although aortic valve (AV) opening during exercise has fewer adverse events in patients with a left ventricular (LV) assist device (LVAD), factors associated with it remain unclear. We hypothesized that right ventricular (RV) reserve function is associated with the AV opening status. This study aimed to explore the hemodynamic parameters observed at rest and during maximal exercise and investigate the association between the RV reserve function and AV opening status in patients with an LVAD.

Association Between Daily Mode of Transportation and Cognitive Function Among Older Adults With Mild Cognitive Impairment: A Cross-Sectional Observational Study.

Background Changes in mode of transportation, such as driving cessation, elevate the risk of mild cognitive impairment (MCI) and Alzheimer's disease among older adults residing in communities. However, the association between transportation-related lifestyles and cognitive function in older adults with MCI remains unclear. This study aimed to explore the relationship between mobility independence and cognitive dysfunction among older patients with MCI.

2-(Cyanomethyl)benzimidazole Derivatives as 1,3-Dicarbonyl Analogues for a Kinetically Controlled Diastereo- and Enantioselective Mannich-Type Reaction Catalyzed by Chiral Phosphoric Acid.

An asymmetric Mannich-type reaction of -protected 2-(cyanomethyl)benzimidazoles with -benzoyl imines was developed by using chiral phosphoric acid as a chiral Brønsted acid catalyst. Products having vicinal trisubstituted carbon stereogenic centers were formed in a highly diastereo- and enantioselective manner, even though one of the stereogenic centers had an active methine proton. Comprehensive control experiments revealed that high stereoselectivity was achieved through a kinetically controlled process.

Effect of imipramine on ejaculatory dysfunction in a rat hypogastric nerve injury model.

Background: Peripheral sympathetic nerve injury, resulting from surgery around the abdominal aorta, including retroperitoneal lymph node dissection for testicular cancer, often causes ejaculatory dysfunction (EjD). EjD reduces sexual activity and male fertility. Imipramine (IMI) has been empirically used for EjD.

A severe case of the bladder inversion treated by total cystectomy and hysterectomy with ileal conduit.

Introduction: Female pelvic organ prolapse (POP) is considered a borderline disease between urology and gynecology and is treated by reconstructive surgery, which restores the organs to their original positions.

Case Presentation: An 82-year-old woman with bladder and uterine prolapse at POP-Q Stage IV was treated with an indwelling catheter for voiding dysfunction. Eventually, the catheter has been often spontaneously removed when pelvic organ prolapse occurs, resulting in a diagnosis of bladder inversion.

Synthesis and crystal structure of 5,10-bis-(phenyl-sulfon-yl)tetra-hydro-dibenzo-penta-lene.

5,10-Bis(phenyl-sulfon-yl)tetra-hydro-dibenzo-penta-lene, CHOS, , was suc-cessfully synthesized the photocatalyst-promoted hy-dro-genative transannulation of di-sulfonyl-cyclo-octa-tetra-ene, , using perylene as the photocatalyst in the presence of (-Pr)NEt under UV-light irradiation (398 nm, 30 W). In this reaction, the cyclo-octa-tetra-ene moiety of underwent hy-dro-genative transannulation, yielding . Single-crystal X-ray analysis revealed that both enanti-omers of are arranged alternately along the axis of the unit cell.

Ultrasound irradiation in the presence of microbubbles may enhance the antitumor effect of chemotherapeutic agents against bladder cancer.

Intravesical instillation of chemotherapy has been performed to reduce the risk of intravesical recurrence of bladder cancer. However, its antitumor effect is not necessarily sufficient, which may be partially due to inadequate delivery of intravesically administered chemotherapeutic agents to bladder tumors. Ultrasound irradiation to target tissues in the presence of microbubbles is a technique to transiently enhance cell membrane permeability and achieve efficient drug delivery to the desired sites without damage to non-target areas; this technique has been used in chemotherapy, immunotherapy, gene therapy, and radiotherapy for the treatment of various cancers.

Suppression of Bone Formation and Resorption by the Deletion of Complex Gangliosides.

Background/aim: Gangliosides regulate bone formation and resorption. Bone formation is reduced in mice lacking ganglioside GM2/GD2 synthase due to a decrease in osteoblasts. However, the effects of the loss of complex gangliosides by the deletion of both GM2/GD2 and GD3 synthases are unknown.

[Clinical Study of Lymph Node Dissection in Robot-Assisted Radical Prostatectomy for High-Risk Prostate Cancer].

We retrospectively analyzed the regions and perioperative outcomes associated with lymph node dissection in patients with prostate cancer. Of 543 patients who underwent robot-assisted radical prostatectomy for prostate cancer with or without lymph node dissection according to the modified D'Amico criteria, 333 (61.3%), 128 (23.

Osteoprotegerin secretion and its inhibition by RANKL in osteoblastic cells visualized using bioluminescence imaging.

Bone remodeling is regulated by the interaction between receptor activator of nuclear factor kappa-B ligand (RANKL) and its receptor RANK on osteoblasts and osteoclasts, respectively. Osteoprotegerin (OPG) is secreted from osteoblasts and inhibits osteoclast differentiation by acting as a decoy receptor for RANKL. Despite its importance, the mechanism underlying the secretion of OPG remains poorly understood.

Mechanical loading-induced alveolar bone remodeling is suppressed in the diabetic state via the impairment of the specificity protein 1/vascular endothelial growth factor (SP1/VEGF) axis.

Aims/introduction: Orthodontic treatment involves alveolar bone remodeling in response to mechanical loading, resulting in tooth movement through traction-side bone formation and compression-side bone resorption. However, there are conflicting reports regarding alveolar bone resorption during the orthodontic treatment of patients with diabetes.

Materials And Methods: Diabetes was induced in 8-week-old C56BL/6J mice using streptozotocin (STZ).

Assessment of Clinicopathological Characteristics and Clinical Outcomes of Patients Who Developed Non-Muscle-Invasive Bladder Cancer After Radiotherapy for Prostate Cancer: A Retrospective Multicenter Study.

Radiotherapy for prostate cancer may induce the development of secondary bladder cancer. However, the clinicopathological characteristics and clinical outcomes of this entity have not been fully elucidated. Therefore, this study compared the clinicopathological characteristics and clinical outcomes of patients who developed secondary bladder cancer after radiotherapy with those of controls.