Effect of balloon angioplasty on inframalleolar stenosis in patients with chronic limb-threatening ischemia.

Background: Although there are reports on angioplasty for inframalleolar (IM) occluded lesions in chronic limb-threatening ischemia (CLTI), the clinical outcomes specific to the IM stenotic lesions remain unclear. This study evaluated the effect of balloon angioplasty for IM stenotic lesions on the clinical outcomes of patients with CLTI.

Methods: This is a multicenter, retrospective, nonrandomized observational study.

Endovascular therapy outcomes in patients with the Global Limb Anatomical Staging System P2 modifier to identify the true no-option anatomic pattern in chronic limb-threatening ischemia.

Objective: In patients with chronic limb-threatening ischemia (CLTI), the Global Limb Anatomical Staging System (GLASS) P2 modifier, defined by the absence of a target artery crossing the ankle and lack of a suitable pedal or plantar artery, indicates a no-option anatomic pattern. Although several studies have reported successful endovascular therapy (EVT) in such patients, EVT outcome predictors in this high-risk population remain unclear. This study aimed to identify factors contributing to procedural failure in patients with the GLASS P2 modifier undergoing EVT.

Impact of Hemodialysis Duration on Arterial Characteristics and Patient Outcomes following Endovascular Therapy for Inframalleolar Occlusive Disease: Results from the MAVERICK Study.

Purpose: To evaluate the effect of hemodialysis (HD) in a medical history of patients with inframalleolar (IM) occlusive disease following balloon angioplasty for de novo occluded IM lesions, specifically focusing on the clinical outcomes related to their HD history.

Materials And Methods: The study had a multicenter, retrospective, nonrandomized, observational design and was performed at 4 cardiovascular centers in Japan. Patients aged ≥20 years with chronic limb-threatening ischemia (CLTI) (Rutherford Classification 5-6) who were treated with endovascular therapy for de novo IM occlusions between January 2016 and December 2022 were included.

Free Flap Limb Salvage and Ulcer Recurrence in Chronic Limb-threatening Ischemia.

Free flap transfer is a well-established treatment for foot reconstruction in patients with chronic limb-threatening ischemia (CLTI) and can achieve prolonged amputation-free survival. However, reports on ulcer recurrence after free flap transfer are scarce, with most focusing on trauma patients. Therefore, we retrospectively reviewed patients with CLTI who underwent free flap reconstruction at our institution over a 17-year period.

Outcomes of revascularization of stenotic inframalleolar lesions in chronic limb-threatening ischemia.

Background: For chronic limb-threatening ischemia, revascularization has been reported for occlusions but not for stenosis in the inframalleolar (IM) lesions. We investigated the clinical outcomes of balloon dilation for stenotic IM lesions distal to the treatment target in the infrapopliteal (IP) legion.

Methods: We conducted a retrospective analysis of patients who had chronic limb-threatening ischemia and underwent revascularization of stenotic IM lesions distal to the target IP lesions between January 2015 and August 2022.

Comparison of Subsequent Inframalleolar Bypass Surgery and Repeat Endovascular Therapy for Infrapopliteal Restenosis in Patients With Chronic Limb-Threatening Ischemia Undergoing Primary Endovascular Therapy.

Purpose: Although endovascular therapy (EVT) is considered a vital strategy for treating infrapopliteal lesions in chronic limb-threatening ischemia (CLTI), the recurrence rate after EVT exceeds that after bypass surgery (BSX). The optimal approach for managing infrapopliteal lesion recurrence in patients with CLTI and unhealed ulcers remains uncertain. This study aimed to evaluate the clinical outcomes of repeat EVT and subsequent inframalleolar BSX for CLTI with infrapopliteal lesion recurrence.

Evaluation of the efficacy of combined device strategies for long femoropopliteal artery disease.

One of the major problems associated with bare nitinol stent implantation is stent fracture, particularly in the popliteal artery. The purpose of this study was to determine whether drug coated balloons (DCB), interwoven stents (IWS), or plain old balloon angioplasty (POBA) would be suitable for use in distal femoropopliteal (FP) long lesions when an Eluvia stent was implanted proximal to a lesion. This was a multi-center retrospective study enrolling patients undergoing concomitant use of Eluvia with DCB, IWS or POBA for symptomatic atherosclerotic femoropopliteal disease (lesion length > 15 cm) [Rutherford category 2-6] between January 2018 and September 2021.

Intravascular ultrasound findings of the protrusion of the EXOSEAL plug that caused acute limb ischemia.

Vascular closure devices have become popular for rapid hemostasis and early ambulation. However, there are a few reports of complications. We presented a case with acute limb ischemia caused by the protrusion of the EXOSEAL plug into the vessel.

Effects of a proteasome inhibitor on the riboflavin production in Ashbya gossypii.

Aims: Effects of a proteasome inhibitor, MG-132, on the riboflavin production in Ashbya gossypii were investigated to elucidate the relationship of the riboflavin production with flavoprotein homeostasis.

Methods And Results: The addition of MG-132 to the liquid medium reduced the specific riboflavin production by 79% in A. gossypii at 25 μM after 24 h.

Efficacy of oral administration of Lentinula eododes mycelia extract for breast cancer patients undergoing postoperative hormone therapy.

Extract of Lentinula edodes mycelia (LEM) is currently utilized as an oral biological response modifier (BRM) medicine for cancer patients. However, its effectiveness for breast cancer patients with postoperative adjuvant hormone therapy has not yet been scientifically verified. In this study, we investigated the influence of LEM on the quality of life (QOL) and immune response in breast cancer patients undergoing postoperative adjuvant hormone therapy.

Determination of the antifungal agent voriconazole in human plasma using a simple column-switching high-performance liquid chromatography and its application to a pharmacokinetic study.

A simple column-switching high performance liquid chromatographic (HPLC) method that does not require any complicated pretreatment has been developed to determine voriconazole in human plasma samples. An internal standard (IS) and borate buffer (pH 9.0) were added to plasma samples, which were then injected directly into the column-switching HPLC system using MAYI-ODS as a pre-column.