Publications by authors named "Yongwang Zhao"
Design of fish-scale microstructured stents and their biomechanical effects on cerebral aneurysm.
Comput Methods Biomech Biomed Engin
February 2025
The addition of microstructures to the inner surface of the stent reduces resistance and inhibits the phenomenon of blood adhesion. In this study, the design of a fish-scale microstructured vascular stent was proposed based on bionics, and its main design parameters were optimized using the finite element method. In addition, the hemodynamic effects of a standard stent and a fish-scale microstructured stent on an ideal cerebral aneurysm were comparatively analyzed.
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- The human retina has various specialized cells that work together to transmit visual signals, but genetic and age-related issues can lead to serious vision impairment or blindness.
- Current treatment options for retinal diseases are limited, highlighting the need for new therapeutic strategies, particularly cell and gene therapies that target retinal cells.
- Two main types of gene delivery systems—viral (like lentiviruses and adeno-associated viruses) and non-viral (such as liposomal technology)—are being explored for effectively delivering therapeutic genes to treat retinal diseases, each with its unique advantages and limitations.
Article Synopsis
- Duck hepatitis virus 1 (DHV-1) poses a serious risk to the poultry industry, leading to high mortality rates in young ducklings and substantial economic losses.
- A phylogenetic analysis identified three distinct groups of DHV-1, each showing unique genetic diversity and preferences in codon usage, notably favoring A/U-ending codons and underscoring the influence of mutation and natural selection.
- The study's findings reveal different evolutionary trends among DHV-1 groups, suggesting that understanding these adaptations could help inform new strategies for controlling the virus and developing vaccines.
Association of Childhood IgA Vasculitis With Allergic Rhinitis and Chronic Rhinosinusitis.
Kidney Int Rep
September 2024
Article Synopsis
- Immunoglobulin A vasculitis (IgAV) in children may be linked to allergic rhinitis (AR) and chronic rhinosinusitis (CRS), as a study analyzed the condition and its associations in hospitalized patients from January to December 2019.
- Among 504 children with IgAV, a significant portion (70.8%) had AR or CRS, with higher occurrences of renal issues and recurrent rashes noted particularly in the simple AR and AR + CRS groups compared to those without AR or CRS.
- The findings suggest that chronic rhinitis could contribute to the development of IgAV, making AR a potential risk factor for more severe symptoms like renal involvement and rashes
The biomechanical effects of different membrane layer structures and material constitutive modeling on patient-specific cerebral aneurysms.
Front Bioeng Biotechnol
January 2024
The prevention, control and treatment of cerebral aneurysm (CA) has become a common concern of human society, and by simulating the biomechanical environment of CA using finite element analysis (FEA), the risk of aneurysm rupture can be predicted and evaluated. The target models of the current study are mainly idealized single-layer linear elastic cerebral aneurysm models, which do not take into account the effects of the vessel wall structure, material constitution, and structure of the real CA model on the mechanical parameters. This study proposes a reconstruction method for patient-specific trilaminar CA structural modeling.
View Article and Find Full Text PDFBackground: Diabetic retinopathy (DR) is a common cause of visual impairment. Apigenin has been shown to have antiangiogenic effects in various diseases. Our study aimed to investigate the role of apigenin in DR and elucidate the underlying mechanism.
View Article and Find Full Text PDFMIAPS: a web-based system for remotely accessing and presenting medical images.
Comput Methods Programs Biomed
July 2014
MIAPS (medical image access and presentation system) is a web-based system designed for remotely accessing and presenting DICOM image. MIAPS is accessed with web browser through the Internet. MIAPS provides four features: DICOM image retrieval, maintenance, presentation and output.
View Article and Find Full Text PDFMolecular genetics of familial nystagmus complicated with cataract and iris anomalies.
Mol Vis
February 2012
Purpose: Familial nystagmus complicated with cataract and iris anomalies are genetically heterogeneous, and the pathophysiological mechanisms remain unclear. It is anticipated that mutations in the paired box 6 (PAX6) gene play a major role in pathogenesis of malformations in anterior segment of the eye. In this study, we analyzed PAX6 in a Chinese pedigree of nystagmus, cataract and iris anomalies.
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Int J Ophthalmol
August 2012
Aim: To analyze mutations in transforming growth factor beta-induced (TGFBI) gene in a Chinese pedigree with Reis-Bücklers corneal dystrophy (RBCD, also known as GCD3).
Methods: In a five-generation Chinese family, eight members were identified with RBCD and the rest were unaffected. All members of the family underwent complete ophthalmologic examinations.