Causal effects and plasma protein mediators between type 2 diabetes and erectile dysfunction: a Mendelian randomization study.

Background: The linkage between type 2 diabetes (T2DM) and erectile dysfunction (ED) is not yet fully understood.

Aim: This study aims to evaluate the causal influence of T2DM on ED and to determine whether plasma proteins mediate this relationship using Mendelian randomization (MR).

Methods: We extracted data on T2DM and plasma proteins from multiple genome-wide association study databases, encompassing European and East Asian populations.

Mitochondrial SLC3A1 regulates sexual dimorphism in cystinuria.

Cystinuria is the most common inheritable cause of kidney stone disease, with males exhibiting a higher susceptibility than females. However, the cellular origin and underlying mechanisms of sex differences in cystinuria remain elusive. This study aims to investigate the mechanism using knockout mice.

Experimental Realization of On-Chip Surface Acoustic Wave Metasurfaces at Sub-GHz.

Metasurfaces, consisting of subwavelength-thickness units with different wave responses, provide an innovative possible method to manipulate elastic and acoustic waves efficiently. The application of metasurfaces to manipulate on-chip surface acoustic wave (SAW) at sub-GHz frequencies requires further exploration since their wave functions are highly demanded in nanoelectromechanical systems (NEMS), sensing, communications, microfluid control and quantum processing. Here, the experimental realization of on-chip SAW metasurfaces is reported, consisting of gradient submicron niobium (Nb) rectangular pillars positioned on a 128°Y-cut lithium niobate (LiNbO) substrate that operate at hundreds of megahertz.

Simulation and experimentation of nonlinear Rayleigh wave inspection of fatigue surface microcracks.

The nonlinear ultrasonic inspection is a method that the higher harmonics generated by the interaction of ultrasound and fatigue damage, which is used to evaluate material properties. In this paper, the difference between experimental measurement and simulation analysis was discussed, based on the simulation and experimentation. The results of simulation and experimentation both show that the nonlinear coefficient increases, reaches the maximum near the wavelength of 0.

Debonding Detection of Thin-Walled Adhesive Structure by Electromagnetic Acoustic Resonance Technology.

The detection of debonding defects in thin-walled adhesive structures, such as clad-iron/rubber layers on the leading edges of helicopter blades, presents significant challenges. This paper proposes the application of electromagnetic acoustic resonance technology (EMAR) to identify these defects in thin-walled adhesive structures. Through theoretical and simulation studies, the frequency spectrum of ultrasonic vibrations in thin-walled adhesive structures with various defects was analyzed.

Concrete Defect Localization Based on Multilevel Convolutional Neural Networks.

Concrete structures frequently manifest diverse defects throughout their manufacturing and usage processes due to factors such as design, construction, environmental conditions and distress mechanisms. In this paper, a multilevel convolutional neural network (CNN) combined with array ultrasonic testing (AUT) is proposed for identifying the locations of hole defects in concrete structures. By refining the detection area layer by layer, AUT is used to collect ultrasonic signals containing hole defect information, and the original echo signal is input to CNN for the classification of hole locations.

Landscape of peripheral immunity in patients with upper urinary tract urolithiasis and the underlying correlations with renal function.

Introduction: Inflammatory and immunological responses are reported involved in the pathogenesis and progression of obstructive nephropathy (ON). This study was designed to investigate the characteristics of peripheral immunity in patients with upper urinary tract urolithiasis and analyze the underlying associations with renal function.

Methods: Patients with unilateral upper urinary tract urolithiasis meeting the operation indications were prospectively enrolled.

Impact of habitual intake of glucosamine, fresh fruit, and tea on the risk of urolithiasis: A two-sample Mendelian randomization study.

Dietary patterns have a significant impact on the occurrence of urolithiasis. This study aimed to investigate the causal relationships between the consumption of glucosamine, fresh fruits, and tea, and the predisposition to urinary stones using a Mendelian randomization (MR) approach. Genetic proxies for these dietary factors were obtained from the UK Biobank, while the summary data for urolithiasis genome-wide association analyses were sourced from the FinnGen consortium.

"Cumulative effect" of second harmonic Lamb waves in a lossy plate.

The second harmonic Lamb waves have high sensitivity to microstructural defects in materials and are therefore promising for incipient damage detection and monitoring of thin-walled structures. Existing studies have shown that the second harmonic Lamb waves can be cumulative with increasing propagation distance under the internal resonance conditions, which is conducive to nonlinear wave measurements in view of structural health monitoring. However, when propagating in a lossy structure with damping, the cumulative properties of the second harmonic Lamb waves are affected by energy dissipation and thus need to be re-examined.

Hybrid Spin and Anomalous Spin-Momentum Locking in Surface Elastic Waves.

Transverse spin of surface waves is a universal phenomenon which has recently attracted significant attention in optics and acoustics. It appears in gravity water waves, surface plasmon polaritons, surface acoustic waves, and exhibits remarkable intrinsic spin-momentum locking, which has found useful applications for efficient spin-direction couplers. Here we demonstrate, both theoretically and experimentally, that the transverse spin of surface elastic (Rayleigh) waves has an anomalous sign near the surface, opposite to that in the case of electromagnetic, sound, or water surface waves.

Elastic Valley Spin Controlled Chiral Coupling in Topological Valley Phononic Crystals.

Distinct from the phononic valley pseudospin, the real physical spin of elastic waves adds a novel tool kit capable of envisaging the valley-spin physics of topological valley phononic crystals from a local viewpoint. Here, we report the observation of local elastic valley spin as well as the hidden elastic spin-valley locking mechanism overlooked before. We demonstrate that the selective one-way routing of valley phonon states along the topological interface can be reversed by imposing the elastic spin metasource at different interface locations with opposite valley-spin correspondence.

Observation of elastic spin with chiral meta-sources.

Directional routing of one-way classical wave has raised tremendous interests about spin-related phenomena. This sparks specifically the elastic wave study of pseudo-spin in meta-structures to perform robust manipulations. Unlike pseudo-spin in mathematics, the intrinsic spin angular momentum of elastic wave is predicted quite recently which exhibits selective excitation of unidirectional propagation even in conventional solids.

Surface circular-arc defects interacted by laser-generated Rayleigh wave.

In this work, the finite element method (FEM) is used to investigate the propagation of laser-generated Rayleigh wave along the material surface at the quarter-arc transition surface under the thermoelastic regime, and to establish the relationship between the circular-arc radius and the time domain characteristics of reflected and transmitted Rayleigh waves. The simulation shows that the amplitude of the reflected Rayleigh wave decreases whereas the amplitude of the transmitted Rayleigh wave increases as the radius increases, which is significantly different from the well-studied interaction of Rayleigh waves with the perpendicular transition surface. By introducing the circular-arc defects which are easily formed in some engineering components during the material surface quenching, we find that the depth gauging of the surface circular-arc defects is more accurate in comparison to the surface rectangular defects based on the arrival time of the transmitted Rayleigh wave.

Gradient Index Devices for the Full Control of Elastic Waves in Plates.

In this work, we present a method for the design of gradient index devices for elastic waves in plates. The method allows the design of devices to control the three fundamental modes, despite the fact that their dispersion relation is managed by different elastic constants. It is shown that by means of complex graded phononic crystals and thickness variations it is possible to independently design the three refractive indexes of these waves, allowing therefore their simultaneous control.

Efficient broadband light absorption in elliptical nanohole arrays for photovoltaic application.

We propose a perpendicular elliptical silicon nanohole (PE-SiNH) array for light absorption in thin film silicon solar cells. Our analysis shows that this architecture is capable of increasing the absorption of a thin film silicon solar cell by 11.3% in comparison to that of the optimal circular SiNH array.