Fexuprazan mitigates NSAID-induced small intestinal injury by restoring intestinal barrier integrity in mice.

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used but frequently cause gastrointestinal (GI) side effects, including ulcers and mucosal erosion. Proton pump inhibitors (PPIs), while effective in preventing NSAID-induced upper GI injury, can worsen small intestinal damage. Potassium-competitive acid blockers (P-CABs), such as fexuprazan, offer potential advantages over PPIs, but their effects on NSAID-induced enteropathy remain unclear.

Skin microbiome-biophysical association: a first integrative approach to classifying Korean skin types and aging groups.

Introduction: The field of human microbiome research is rapidly expanding beyond the gut and into the facial skin care industry. However, there is still no established criterion to define the objective relationship between the microbiome and clinical trials for developing personalized skin solutions that consider individual diversity.

Objectives: In this study, we conducted an integrated analysis of skin measurements, clinical Baumann skin type indicator (BSTI) surveys, and the skin microbiome of 950 Korean subjects to examine the ideal skin microbiome-biophysical associations.

The effects of candidate probiotic strains on the gut environment in dextran sulfate sodium-induced colitis mouse.

Inflammatory bowel disease (IBD) is a chronic condition characterized by intestinal inflammation and dysbiosis, with limited treatment options and significant challenges in long-term management. This study investigated the therapeutic potential of novel strains belonging to Bifidobacterium longum and Limosilactobacillus species, in a dextran sodium sulfate (DSS)-induced mouse model of colitis. In this study, our primary objective was to determine whether ingestion of these strains alleviates colitis symptoms and, if so, to elucidate how they restored gut microbial balance and modulated microbial metabolic functions.

Effect of Helicobacter pylori on sleeve gastrectomy and gastric microbiome differences in patients with obesity and diabetes.

Background: Obesity and diabetes mellitus (DM) have become public health concerns worldwide. Both conditions have severe consequences and are associated with significant medical costs and productivity loss. Additionally, Helicobacter pylori infection may be a risk factor for the development of these conditions.

Alterations in gastric and gut microbiota following sleeve gastrectomy in high-fat diet-induced obese rats.

Obesity is considered a high-risk disease and a global epidemic, and the number of obese patients is rising at an alarming rate worldwide. High-fat diet-induced dysbiosis of the intestinal microbiota is considered an essential factor related to obesity. Bariatric surgery induces a sharp decrease in fat content and effectively improves the metabolism of obese individuals.

The effects of long-pulsed alexandrite laser therapy on facial redness and skin microbiota compositions in rosacea: A prospective, multicentre, single-arm clinical trial.

Background: Rosacea is a chronic skin disorder characterised by abnormal neurovasculature and inflammation in the central region of the face. The efficacy of pulsed-dye laser and intense pulsed light treatments for rosacea have been demonstrated in several clinical trials. However, there is currently no research on the efficacy of long-pulsed alexandrite laser (LPAL) therapy alone for rosacea-related facial redness and its effect on skin microbiota.

A Real-Time Detection Device for the Rapid Quantification of Skin Casual Sebum Using the Oil Red O Staining Method.

The human skin sebum suggests that it (along with other epidermal surface lipids) plays a role in skin barrier formation, the moderation of cutaneous inflammation, and antimicrobial defense. Various methods have been developed for collecting and measuring skin sebum. We tested methods of detection using "color intensity", by staining the skin casual sebum.

Effect of Supplementation on the Gut Microbial Composition of Healthy Korean Adults: A Single-Group Pilot Study.

is a type of meal-replacement product or dietary supplement comprising an uncooked and dried plant-based food mixture with various health-promoting properties, such as antidiabetic, anti-dyslipidemic, antioxidant, and anticancer properties. Although these properties are considered attributable to the various bioactive components absorbed through the intestine and its remolding effect on intestinal microorganisms, the effect of supplementation on gut microbiota profiles has not yet been studied. In this study, we investigated the effect of administration on the composition of gut microbiota.

The effect of taxonomic classification by full-length 16S rRNA sequencing with a synthetic long-read technology.

Characterizing the microbial communities inhabiting specimens is one of the primary objectives of microbiome studies. A short-read sequencing platform for reading partial regions of the 16S rRNA gene is most commonly used by reducing the cost burden of next-generation sequencing (NGS), but misclassification at the species level due to its length being too short to consider sequence similarity remains a challenge. Loop Genomics recently proposed a new 16S full-length-based synthetic long-read sequencing technology (sFL16S).

Performance comparison of fecal preservative and stock solutions for gut microbiome storage at room temperature.

The gut microbiome, which is symbiotic within the human body, assists in human digestion. It plays significant roles in identifying intestinal disease as well as in maintaining a healthy body with functional immune and metabolic activities. To confirm the consistency of fecal intestinal microbial research, it is necessary to study the changes in intestinal microbial flora according to the fecal collection solution and storage period.

Comparative transcriptome analysis identified candidate genes involved in mycelium browning in Lentinula edodes.

Background: Lentinula edodes is one of the most popular edible mushroom species in the world and contains useful medicinal components, such as lentinan. The light-induced formation of brown film on the vegetative mycelial tissues of L. edodes is an important process for ensuring the quantity and quality of this edible mushroom.

TaF: a web platform for taxonomic profile-based fungal gene prediction.

Introduction: The accurate prediction and annotation of gene structures from the genome sequence of an organism enable genome-wide functional analyses to obtain insight into the biological properties of an organism.

Objectives: We recently developed a highly accurate filamentous fungal gene prediction pipeline and web platform called TaF. TaF is a homology-based gene predictor employing large-scale taxonomic profiling to search for close relatives in genome queries.

An efficient and tunable parameter to improve variant calling for whole genome and exome sequencing data.

Next generation sequencing (NGS) has traditionally been performed in various fields including agricultural to clinical and there are so many sequencing platforms available in order to obtain accurate and consistent results. However, these platforms showed amplification bias when facilitating variant calls in personal genomes. Here, we sequenced whole genomes and whole exomes from ten Korean individuals using Illumina and Ion Proton, respectively to find the vulnerability and accuracy of NGS platform in the GC rich/poor area.

Long-read transcriptome data for improved gene prediction in .

is one of the most popular edible mushrooms in the world and contains useful medicinal components such as lentinan. The whole-genome sequence of has been determined with the objective of discovering candidate genes associated with agronomic traits, but experimental verification of gene models with correction of gene prediction errors is lacking. To improve the accuracy of gene prediction, we produced 12.

Isoform Sequencing Provides a More Comprehensive View of the Panax ginseng Transcriptome.

Korean ginseng ( C.A. Meyer) has been widely used for medicinal purposes and contains potent plant secondary metabolites, including ginsenosides.