Simulation Use within Respiratory Therapy Education Programs: A Review.

Simulation-based education (SBE) refers to the use of specialized equipment in a controlled setting to enable learners to safely practice real-life procedures and scenarios. Though the respiratory therapy (RT) profession was an early-adopter of SBE and many RT education programs report its use, there have been few attempts to examine the related literature and report on broad themes in this area. Hence, the purpose of this explorative paper is to provide readers with an enhanced understanding of SBE trends within RT academic education, which may help promote a more informed use and encourage more scholarly work in this area.

Breast cancer and microbiome: a systematic review highlighting challenges for clinical translation.

Purpose: Breast cancer, the most common cancer in women worldwide, is linked to microbiome imbalances. This suggests the potential for microbiome-based breast cancer management. However, a comprehensive and reproducible understanding of the microbiome's role in breast cancer is lacking.

PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation.

Hearing loss is one of the most prevalent sensory disorders, but no commercial biological treatments are currently available. Here, we identify an East Asia-specific founder mutation, the homozygous c.220 C > T mutation in MPZL2, that contributes to a significant proportion of hereditary deafness cases in our cohort study.

Use of cultural appropriateness strategies and behavioral frameworks in behavioral interventions for black and hispanic cancer survivors: a systematic review.

Background: Black and Hispanic cancer survivors experience significant inequities in supportive cancer care. Incorporating cultural appropriateness strategies and behavioral frameworks into supportive care interventions can improve cancer outcomes of Black and Hispanic survivors. This review evaluated behavioral oncology trials for Black and Hispanic cancer survivors to assess their use of cultural appropriateness strategies and behavioral frameworks.

Validation of suitable reference microRNAs for qRT-PCR in under abiotic stress, hormone and metal ion treatments.

Introduction: Sweet osmanthus () is a prominent woody ornamental plant extensively utilized in horticulture, the food industry, cosmetics, and traditional Chinese medicine. MicroRNAs (miRNAs) are crucial regulators of gene regulation, playing a vital role in enabling plants to adapt to environmental fluctuations. Despite their significance, research on miRNA expression in under adverse stress conditions remains limited.

Selection of suitable reference lncRNAs for gene expression analysis in under abiotic stresses, hormone treatments, and metal ion treatments.

Intoduction: , a well-regarded traditional flower in China, holds extensive applications in gardening, food, cosmetics, and traditional Chinese medicine. Despite its importance, research on long non-coding RNAs (lncRNAs) in has been constrained by the absence of reliable reference genes (RGs).

Methods: We employed five distinct algorithms, i.

The impact of ACOG's 39-week rule on fetal death rates in the United States: A systematic review.

Objective: The "39-week rule," implemented in August 2009, strongly discouraged early term deliveries before 39 weeks without accepted ACOG delivery indications. In this study, we evaluated fetal death rates before and after the 39-week rule in the United States (US) by review of published series.

Study Design: Systematic literature searches were performed in PubMed, Cochrane Central Register of Controlled Trials, Embase, Cumulative Index to Nursing and Allied Health Literature, Web of Science, and Scopus databases (January 2009-June 2023).

Effectiveness of a theory-based tailored mHealth physical activity intervention for women undergoing chemotherapy for breast cancer: A quasi-experimental study.

Objectives: This study aimed to explore the effectiveness of the theory-based tailored mHealth physical activity (PA) intervention among patients with breast cancer undergoing chemotherapy.

Methods: A quasi-experimental study design was adopted. A total of 60 breast cancer patients were selected from two tertiary hospitals in Shanghai and Hangzhou City from September 2019 to August 2021.

CfSGR1 and CfSGR2 from Cryptomeria fortunei exhibit contrasting responses to hormones and abiotic stress in transgenic Arabidopsis.

Stay-green (SGR) genes are pivotal regulatory genes in the context of plant chlorophyll metabolism, but few studies on SGR homologues in Cryptomeria fortunei have been previously reported. We cloned two CfSGR genes and overexpressed them in Arabidopsis to explore their functions. Full-length CfSGR1 and CfSGR2 are 1265 and 1197 bp, encompassing open reading frames (ORFs) encoding 274 and 276 amino acids, respectively.

Comparative Cardiovascular Safety of Gonadotropin-releasing Hormone Antagonists and Agonists Among Patients Diagnosed with Prostate Cancer: A Systematic Review and Meta-analysis of Real-world Evidence Studies.

Background And Objective: Gonadotropin-releasing hormone (GnRH) antagonists and agonists are cornerstone treatments in prostate cancer. However, evidence regarding the comparative cardiovascular safety of these drugs from clinical trials is inconclusive. The objective of this study was to systematically assess the risk of adverse cardiovascular events of GnRH antagonists compared with GnRH agonists across real-world evidence studies.

Targeting SIRT2 in Aging-Associated Fibrosis Pathophysiology.

Aging is a complex biological process that involves multi-level structural and physiological changes. Aging is a major risk factor for many chronic diseases. The accumulation of senescent cells changes the tissue microenvironment and is closely associated with the occurrence and development of tissue and organ fibrosis.

Targeting inhibition of TCTP could inhibit proliferation and induce apoptosis in AML cells.

Translationally controlled tumor protein (TCTP) is a highly conserved multifunctional protein, which participates in many important physiological processes. Recently, the roles of TCTP in cell proliferation and apoptosis, especially its close relationship with various tumors, have attracted widespread attention. In this study, we found that the protein level of TCTP was significantly reduced in acute promyelocytic leukemia cell line NB4 transfected with retinoic acid-induced gene G (RIG-G).

Impact of the COVID-19 pandemic on brachytherapy and cancer patient outcomes: A systematic review.

Purpose/objective(s): To assess the impact of the COVID-19 pandemic on the use of brachytherapy in patients with gynecologic and prostate cancers including treatment delays, increased burden of mortality, and associated clinical outcomes.

Materials/methods: A comprehensive search of PubMed, Cochrane Library, CINAHL, Scopus, and Web of Science was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Databases were searched for studies published through September 2023 using MeSH terms and keywords related to "COVID and brachytherapy.

Extracervical Approaches to Substernal Thyroid Goiter Resection: A Systematic Review and Meta-Analysis.

Objective: To evaluate the prevalence of extracervical approaches (ECAs) for substernal goiter (SSG) excision.

Data Sources: Search strategies created in collaboration with a medical librarian were implemented using PubMed, Cochrane, Scopus, Web of Science, and Google Scholar from inception to July 2021.

Review Methods: Participants included adults ages >18 years undergoing SSG excision.

Describing the evidence linking interprofessional education interventions to improving the delivery of safe and effective patient care: a scoping review.

Empirical evidence indicates that collaborative interprofessional practice leads to positive health outcomes. Further, there is an abundance of evidence examining student and/or faculty perceptions of learning or satisfaction about the interprofessional education (IPE) learning experience. However, there is a dearth of research linking IPE interventions to patient outcomes.

Acid-suppressive medication and incidence of chronic childhood immune-mediated diseases: A scoping review.

Background: Use of acid-suppressive medications (ASMs), for example, proton pump inhibitors (PPIs) and histamine-2 receptor antagonists (H2RAs), has been rising along with the incidence of pediatric immune-mediated diseases (IMDs). We conducted a scoping review to characterize the literature about prenatal or pediatric exposure to ASMs in relation to incident pediatric IMDs.

Methods: Electronic searches were conducted to identify studies from 2001 to 2023 on (a) prenatal or pediatric exposure to PPIs and/or H2RAs and (b) the risk of developing chronic IMDs during childhood.

Two R2R3-MYB transcription factors from Chinese cedar (Cryptomeria fortunei Hooibrenk) are involved in the regulation of secondary cell wall formation.

As the most abundant renewable energy source, wood comprises the secondary cell wall (SCW). SCW biosynthesis involves lignin and cellulose deposition. Increasing studies have illustrated that R2R3-MYB transcription factors (TFs) play pivotal roles in affecting lignin accumulation and SCW formation.

SIRT2 regulates extracellular vesicle-mediated liver-bone communication.

The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 expression is increased in aged mice and elderly humans.

Trends In... Librarians and Faculty Status.

Within academic libraries there are a variety of models for faculty status or classification applicable to librarians within their institutions. Some librarian positions are tenure track, some are non-tenure track, and some are classified as non-faculty administrative staff roles. This column will outline things to consider when a librarian classified as staff, professional or non-faculty is approached to take on a faculty role in an academic department outside of the library or is presented with the opportunity to pursue faculty status as a librarian.

Physiological and gene expression changes of Hooibrenk families under heat stress.

Heat stress is one of the major abiotic stresses affecting plant growth and productivity. (Chinese cedar) is an excellent timber and landscaping tree species in southern China thanks to its beautiful appearance, straight texture and ability to purify the air and improve the environment. In this study, we first screened 8 excellent families (#12, #21, #37, #38, #45, #46, #48, #54) in a second generation seed orchard.

Preparation of Au-RGO/TiO nanotubes and study on the photocatalytic degradation of ciprofloxacin.

Au-RGO/TiO nanotubes were prepared by anodic oxidation and electrochemical deposition, and their performance in the photocatalytic degradation of ciprofloxacin was investigated. The results showed that, compared with TiO nanotubes and RGO/TiO nanotubes, the Au-RGO/TiO nanotubes had the highest ciprofloxacin degradation rate, reaching 96.93% in 180 min of photocatalysis.

Emerging role of aging in the progression of NAFLD to HCC.

With the aging of global population, the incidence of nonalcoholic fatty liver disease (NAFLD) has surged in recent decades. NAFLD is a multifactorial disease that follows a progressive course, ranging from simple fatty liver, nonalcoholic steatohepatitis (NASH) to liver cirrhosis and hepatocellular carcinoma (HCC). It is well established that aging induces pathological changes in liver and potentiates the occurrence and progression of NAFLD, HCC and other age-related liver diseases.

Overexpression of from Enhances Cold, Drought and Salt Stress in Poplar.

, a regulator of the cold-inducible transcriptome and freezing tolerance, is currently widely believed to be involved in plant resistance to cold stress. In this study, from was transformed into poplar. Physiological indicators of transgenic, empty vector and wild-type poplar after abiotic stress (cold, drought and salt) were determined.