Controlled ovarian stimulation protocols for assisted reproduction: a network meta-analysis.

Background: Controlled ovarian stimulation (COS) is an essential step in most assisted conception cycles. Different treatment combinations (termed protocols) exist in COS, yet there is no consensus on their relative effectiveness and safety.

Objectives: We aimed to assess the relative effectiveness and safety of COS protocols in clinical practice.

The Association Between Periconceptual Maternal Dietary Patterns and Miscarriage Risk in Women With Recurrent Miscarriages: A Multicentre Cohort Study.

Objective: To examine the association between periconceptual maternal diet and miscarriage risk among women with recurrent miscarriages.

Design: Prospective multicentre cohort study (Tommy's Net).

Setting: Three university hospital research centres in the United Kingdom.

The association between dietary patterns and risk of miscarriage: a systematic review and meta-analysis.

Importance: The evidence on the association between diet and miscarriage risk is scant and conflicting.

Objective: To summarize the evidence on the association between periconceptual diet and miscarriage risk in healthy women of reproductive age.

Data Sources: Electronic databases were searched from inception to August 2022 without restriction of regions, publication types, or languages.

The effect of frozen embryo transfer regimen on the association between serum progesterone and live birth: a multicentre prospective cohort study (ProFET).

Study Question: What is the association between serum progesterone levels on the day of frozen embryo transfer (FET) and the probability of live birth in women undergoing different FET regimens?

Summary Answer: Overall, serum progesterone levels <7.8 ng/ml were associated with reduced odds of live birth, although the association between serum progesterone levels and the probability of live birth appeared to vary according to the route of progesterone administration.

What Is Known Already: Progesterone is essential for pregnancy success.

Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.

Some neuropsychiatric disease, including schizophrenia, may originate during prenatal development, following periods of gestational hypoxia and placental oxidative stress. Here we investigated if gestational hypoxia promotes damaging secretions from the placenta that affect fetal development and whether a mitochondria-targeted antioxidant MitoQ might prevent this. Gestational hypoxia caused low birth-weight and changes in young adult offspring brain, mimicking those in human neuropsychiatric disease.

Current pregnancy outcomes in women with cystic fibrosis.

Objectives: Women with cystic fibrosis (CF) now achieve a greater life expectancy and therefore have greater expectations from life. Literature reporting pregnancy outcomes in CF is still sparse. There remains a legacy of advising women with significant disease to avoid pregnancy.

Validation and compliance of a home monitoring device in pregnancy: microlife WatchBP home.

Objective: To assess the accuracy and patient compliance in using a novel home blood pressure monitoring device in high-risk pregnancy.

Methods: Device accuracy was assessed according to the British Hypertension Society protocol in 45 pregnant women, including 15 with preeclampsia. Twenty-one high-risk pregnant women used the device in addition to their antenatal care.