Publications by authors named "Pedro Melo"

In recent studies, public health has been considered a key stakeholder in climate mitigation and adaptation in cities since they are more exposed to the impact of climate change. Nurses represent a vast majority of public health professionals, playing a key role in health promotion that allows them to influence individuals, families, and communities in adopting healthier behaviours and decarbonized lifestyles. Therefore, the purpose of this study is to map the existing evidence on nursing interventions, which are being led or implemented to reduce the health risks related to climate change in urban areas.

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Introduction: The contribution of respiratory models to understanding and predicting functional capacity abnormalities in chronic obstructive pulmonary disease (COPD) has not yet been investigated.

Purpose: The aims of this study were: (1) To investigate the associations between the extended Resistance-Inertance-Compliance (eRIC) and the fractional-order (FrOr) models with changes in Glittre-ADL and handgrip tests and; (2) To evaluate the accuracy of these models in predicting abnormal functional capacity in COPD.

Patients And Methods: The study was carried out in a group of 40 adults with COPD and a control group of 40 healthy individuals, both evaluated by respiratory oscillometry, spirometry, Glittre-ADL test and handgrip test.

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The Fisher information (FI) metric is a Riemannian metric that allows a geometric treatment of stochastic thermodynamics, introducing the possibility of computing thermodynamic lengths and deviations from equilibrium. At the trajectory level, a related quantity can be introduced, the stochastic Fisher information (SFI), which, on average, is equivalent to the FI. In this work, we discuss two fundamental questions regarding the SFI; namely, (i) what is the thermodynamic interpretation of the SFI, and (ii) are there any trajectory-level thermodynamic bounds.

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Background: It is unclear whether weight loss before in vitro fertilization (IVF) improves reproductive outcomes in women with obesity.

Purpose: To assess whether weight loss interventions before IVF improve reproductive outcomes.

Data Sources: Five electronic databases through 27 May 2025.

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Coronary microvascular obstruction and dysfunction (CMVO) frequently arise following primary percutaneous coronary intervention (PCI), particularly in individuals with myocardial infarction. Despite the restoration of epicardial blood flow, microvascular perfusion might still be compromised, resulting in negative clinical outcomes. CMVO is a complex condition resulting from a combination of ischemia, distal thrombotic embolization, reperfusion injury, and individual susceptibilities such as inflammation and endothelial dysfunction.

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Background: Early reperfusion after ST-segment-elevation myocardial infarction is essential for limiting infarct size. However, reperfusion injury can lead to progressive microvascular obstruction (MVO), reducing myocardial blood flow (MBF), aggravating ischemia and myocardial necrosis. We hypothesized that SuperSaturated Oxygen (SSO) Therapy may reduce infarct size by alleviating MVO, so we evaluated the effects of SSO on the time course of MBF and MVO in a preclinical ischemia/reperfusion model.

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Retained products of conception (RPOC) is a common complication following first-trimester pregnancy loss. However, there are no formal recommendations regarding the diagnosis of RPOC. This systematic review aimed to synthesise and critically appraise the existing evidence on the definition and diagnostic criteria for RPOC.

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Background: Controlled ovarian stimulation (COS) is an essential step in most assisted conception cycles. Different treatment combinations (termed protocols) exist in COS, yet there is no consensus on their relative effectiveness and safety.

Objectives: We aimed to assess the relative effectiveness and safety of COS protocols in clinical practice.

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The present study aimed to analyze changes in symptom intensity during the recovery period of COVID-19 survivors and patients with post-COVID syndrome. Initially, we described a new remote patient monitoring system to track the intensity of specific symptoms in individuals' home environments. Remote patient monitoring (RPM) was implemented over 15 days in a cohort of 133 individuals aged 20 to 78 years, divided into four groups: mild (MG, n = 40), Hospital Discharge Without Invasive Mechanical Ventilation (WIMV, n = 40), Hospital Discharge With Invasive Mechanical Ventilation (IMV, n = 13), and reinfected (RG, n = 40).

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Continuous Integration and Continuous Deployment are known methodologies for software development that increase the overall quality of the development process. Several robotic software repositories make use of CI/CD tools as an aid to development. However, very few CI pipelines take advantage of using cloud computing to run simulations.

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Drug-eluting resorbable scaffolds (DRS) are conceptually attractive for treatment of peripheral arterial disease, particularly below-the-knee. MOTIV is a peripheral variant of REVA Medical's well-established, radiopaque tyrosine-polycarbonate (Tyrocore) sirolimus-eluting DRS. The purpose of this study was to provide imaging and histopathologic data on vascular response to MOTIV in porcine peripheral arteries.

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The article by De Oliveira et al. presents an insightful systematic review and meta analysis comparing intravenous tirofiban and oral aspirin in acute ischemic stroke (AIS) patients. It has sparked substantial discussions among my colleagues and me, particularly regarding the optimal circumstances for administering intravenous tirofiban in AIS patients ineligible for reperfusion therapies.

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In this manuscript, we investigate the stochastic thermodynamics of Fisher information (FI), meaning we characterize both the fluctuations of FI, introducing a statistics of that quantity, and thermodynamic quantities. We introduce two initial conditions: an equilibrium initial condition and a minimum entropy initial condition, both under a protocol that drives the system to equilibrium. Its results indicate a dependence of the average FI on both the initial condition and path taken.

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Background: Sarcoidosis is a multisystemic syndrome of uncertain etiology with abnormal respiratory findings in approximately 90% of cases. Spirometry is the most common lung function test used for assessing lung function in diagnosis and monitoring pulmonary health. Respiratory oscillometry allows a simple alternative for the analysis of respiratory abnormalities.

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Objective: To examine the association between periconceptual maternal diet and miscarriage risk among women with recurrent miscarriages.

Design: Prospective multicentre cohort study (Tommy's Net).

Setting: Three university hospital research centres in the United Kingdom.

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Article Synopsis
  • * Methods: Conducted at a referral center in Portugal, the study involved RP patients who completed a questionnaire about their vision and underwent detailed eye scans. Morphometric parameters were analyzed, and correlations between clinical data and questionnaire responses were examined.
  • * Results: The study involved 23 RP patients with CME and 69 without it, showing no significant differences in self-reported visual function. While age positively correlated with vision-related quality of life, visual acuity
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Background: Asthma onset or worsening of the disease in adulthood may be associated with occupational asthma (OA) or work-exacerbated asthma (WEA). Oscillometry and respiratory modeling offer insight into the pathophysiology and contribute to the early diagnosis of respiratory abnormalities.

Purpose: This study aims to compare the changes due to OA and WEA and evaluate the diagnostic accuracy of this method.

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The Brazil-Malvinas Confluence (BMC) is a significant biological frontier where distinct currents meet, fostering optimal conditions for phytoplankton development. In this study we tested the hypothesis that eddys promote an increase in phytoplankton biomass at the Brazil-Malvinas Confluence (BMC), altering species diversity. Phytoplankton were collected with Niskin bottles and nutrient concentrations assessed at two depths (Surface and Deep Chlorophyll Maximum Layer - DCML) in areas outside and under the influence of Cold-Core (CCE) and Warm-Core (WCE) Eddies.

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Additive manufacturing (AM), also known as 3D printing, offers many advantages and, particularly in the medical field, it has stood out for its potential for the manufacture of patient-specific implantable devices. Thus, the unique properties of 3D-printed biocompatible polymers such as Polylactic Acid (PLA) and Polyetheretherketone (PEEK) have made these materials the focus of recent research where new post-processing and joining techniques need to be investigated. This study investigates the weldability of PLA and PEEK 3D-printed plates through stationary shoulder friction stir welding (SS-FSW) with assisted heating.

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Oceanic oil spills present significant ecological risks that have the potential to contaminate extensive areas, including coastal regions. The occurrence of the 2019 oil spill event in Brazil resulted in over 3000 km of contaminated beaches and shorelines. While assessing the impact on benthic and beach ecosystems is relatively straightforward due to direct accessibility, evaluating the ecotoxicological effects of open ocean oil spills on the pelagic community is a complex task.

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Article Synopsis
  • Colloidal nanocrystals have advanced in size and surface properties, leading to potential applications in optoelectronics and quantum materials.
  • The study focuses on two-dimensional BiSe crystals with controlled thickness, exploring the transition of a topological insulator as it shifts from three to two dimensions.
  • Results reveal an 8 nm wide edge state around specific BiSe structures and discuss its characteristics using advanced theoretical models, also suggesting the possible state density for future devices.
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Purpose: Chronic obstructive pulmonary disease (COPD) phenotypes may introduce different characteristics that need to be known to improve treatment. Respiratory oscillometry provides a detailed analysis and may offer insight into the pathophysiology of COPD. In this paper, we used this method to evaluate the differences in respiratory mechanics of COPD phenotypes.

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Article Synopsis
  • Some women trying to get pregnant with embryo transfers have a hard time, known as recurrent implantation failure (RIF), and doctors are looking for ways to help them.
  • This study looked at whether a special type of medicine, called immunomodulators, could increase the chances of having a baby for women with RIF who were undergoing treatment.
  • The results showed that women who took immunomodulators had a better chance of having a baby compared to those who only received standard treatment, with a live birth rate of 20.9% versus 15.8%.
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Hyperglycaemia affects more than 30% of adults hospitalized for non-critical illness and is associated with an increased risk of adverse clinical outcomes. Insulin therapy is widely used for its safety and efficacy. However, given the growing availability of new drugs and new classes of antidiabetic agents with benefits beyond glycaemic control, challenges arise regarding their use in the hospital setting.

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Background: The efficacy of coronary computed tomography angiography (CCTA) versus invasive coronary angiography (ICA) among patients with stable chest pain has been studied in several trials with conflicting results.

Methods: We performed a systematic review and meta-analysis comparing CCTA first versus direct ICA among patients with stable chest pain, who were initially referred to ICA. PubMed, EMBASE, and Cochrane Central were searched for randomized controlled trials comparing the 2 strategies.

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