The impact of individual health on relative poverty: evidence from China.

Background: Following China's historic achievement in eradicating absolute poverty, the focus of anti-poverty policies has shifted to alleviating relative poverty, with health status playing a pivotal role in sustainable poverty reduction.

Methods: Based on the 2021 Chinese General Social Survey (CGSS 2021), we employed structural equation modeling (SEM) to analyze the relationship between individual health and relative poverty.

Results: The analyses showed a significant negative correlation between individual health and relative poverty.

Dysbiotic gut fungi exacerbate Klebsiella peumoniae lung infection via Dectin-1-mediated alveolar macrophage hyperactivation.

Escalating antibiotic resistance of Klebsiella pneumoniae underscores the urgent need for therapeutic strategies. Whereas gut bacterial dysbiosis exacerbates pulmonary infections, the role of gut fungi in modulating lung immunity remains understudied. Here, we demonstrate that antibiotic-induced gut fungal expansion aggravates pneumonia by enhancing alveolar macrophage-driven inflammation via Dectin-1 signaling.

Role of AQP1 in the Ameliorating Effect of Electroacupuncture in a Rodent Model of Visceral Hypersensitivity.

Background: Aquaporins 1 (AQP1), the first water channel protein, is involved in central and peripheral nociception. However, it remains unclear whether AQP1 contributes to visceral hypersensitivity. We hypothesize that AQP1 contributes to acetic acid-induced visceral hypersensitivity in a rat model of irritable bowel syndrome (IBS) and that electroacupuncture (EA) improves visceral hypersensitivity by down-regulating the expression of AQP1 in enteric glial cells (EGCs) and dorsal root ganglion (DRG).

aGenome-scale activation screen reveals lncRNA HNF1A-AS1 promotes pancreatic cancer metastasis through interacting with U2SURP to increase CD44 alternative splicing.

Background: Pancreatic cancer (PC) has a strong ability to invade and metastasize, which has brought insurmountable obstacles to the treatment of PC. Exploring the molecular mechanism of PC metastasis is still the focus of PC research. The purpose of this study was to explore the molecular mechanism of long noncoding RNA HNF1A-AS1 in promoting PC metastasis, hoping to provide help for the diagnosis and treatment of PC.

ABC-seq Expands Small RNAs Profiling with Successive Nucleic Acid Structure-Differentiated Enzymatic Recognition.

Small RNAs (smRNAs) play crucial roles in gene regulation, but current sequencing methods face a set of tangled challenges, including adapter ligation bias, high adapter dimer byproducts, and amplification variability, which limit their capacity to fully capture smRNA diversity. Here, we develop ABC-seq, a general strategy to enhance smRNA recognition through successive structure-differentiated recognition. We designed two randomized adapters, each containing a restriction enzyme recognition motif or a cleavage site.

Identification of the clinical value and biological effects of TTN mutation in liver cancer.

Liver cancer, a malignant tumor of the digestive system, is a leading cause of cancer‑related mortality globally. Numerous genetic mutations associated with tumorigenesis have been identified, stemming from genomic instability. However, the clinical implications and therapeutic relevance of these mutations remain poorly understood.

Association between AHR in EGCs and IBS-D patients: the indole pathway of tryptophan metabolism.

Background: The pathophysiological mechanisms of irritable bowel syndrome (IBS) are intricate, and associated with tryptophan metabolites. This study was designed to investigate the relationship between indole metabolites in the feces and intestinal function in patients with IBS.

Methods: In this study, 42 patients with diarrhea-predominant IBS (IBS-D) and 36 healthy controls were recruited.

Identification of Polyamines in Human Milk, Formula Milk, and Other Dairy Products: a Special Method Based on Precolumn Derivatization, Double-Florisil Purification, and Gas Chromatography-Triple Quadrupole Mass Spectrometry.

Polyamines in human milk are essential for the rapid growth and development of neonates and infants. However, the concentrations of polyamines in human milk have not been well characterized and the special methods for detecting polyamines in human milk, formula milk, or other dairy products remain largely unavailable to date. In this study, an accurate and sensitive method based on trifluoroacetic acid anhydride (TFAA) derivatization, double solid-phase extraction (SPE) purification, and gas chromatography-triple quadrupole mass spectrometry (GC-QqQ MS) was established for the evaluation of polyamines in human milk, formula milk, and other dairy products.

Effects of trigger-day progesterone in c-IVF/ICSI cycles on blastocyst culture outcomes.

Objective: To assess whether trigger-day progesterone (P) levels in conventional fertilization (c-IVF)/intracytoplasmic sperm injection (ICSI) cycles are associated with blastocyst culture outcomes.

Methods: In this retrospective analysis, 747 eligible patients (747 cycles) who adopted the gonadotropin-releasing hormone (GnRH) antagonist protocol and underwent c-IVF/ICSI between January 2021 to June 2024 were recruited. The P cutoff values were 1.

Proteome-Wide Mendelian Randomization Analysis to Identify Potential Plasma Biomarkers and Therapeutic Targets for Epithelial Ovarian Cancer Subtypes.

Background: Epithelial ovarian cancer (EOC) remains an unmet medical challenge due to its insidious onset, atypical symptoms, and increasing resistance to conventional chemotherapeutic agents. It is imperative to explore novel biomarkers and generate innovative target drugs.

Methods: To identify potential proteins with causal association to EOC subtypes, we conducted a Mendelian Randomization (MR) analysis using 15,419 protein quantitative trait loci (pQTLs) associated with 2015 proteins.

A rare prenylated isoflavone-quinone from the roots of .

In order to make more rational use of , a systematic separation from the roots of was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (), together with four known analogues (). Their structures were established by extensive physical and spectroscopic data analysis.

Proinflammatory Diet Increases the Risk of Irritable Bowel Syndrome: A Prospective Study of 129,408 UK Biobank Participants and Mendelian Randomization Analysis.

Background: Patients with irritable bowel syndrome (IBS) often have chronic low-grade inflammation in the intestinal mucosa. Some dietary components are known to be associated with inflammation. However, there is currently limited research on the relationship between dietary inflammatory potential and the risk of IBS.

Inhibition of JNK Signaling Overcomes Cancer-Associated Fibroblast-Mediated Immunosuppression and Enhances the Efficacy of Immunotherapy in Bladder Cancer.

Currently, only 20% to 40% of patients with cancer benefit from immune checkpoint inhibitors. Understanding the mechanisms underlying the immunosuppressive tumor microenvironment (TME) and characterizing dynamic changes in the immunologic landscape during treatment are critical for improving responsiveness to immunotherapy. In this study, we identified JNK signaling in cancer-associated fibroblasts (CAF) as a regulator of the immunosuppressive TME.

[Multidimensional supportive psychological intervention in clinical practice teaching of andrological nursing].

Objective: To examine the application of a novel pedagogical approach multidimensional supportive psychological intervention (MSPI) in the clinical practice teaching of andrological nursing care.

Methods: Using the Hamilton Depression Scale (HAMD), we assessed the psychology of 100 nursing interns about to enter clinical practice in the Department of Andrology from December 2021 to December 2022. We equally randomized the subjects into an experimental and a control group, the former receiving MSPI and the latter trained on the conventional teaching model without any psychological support intervention.

Effect of body mass index on progesterone level on trigger day in gonadotropin-releasing hormone antagonist cycles.

Objective: To investigate the effect of body mass index (BMI) on progesterone (P) level on trigger day in gonadotropin-releasing hormone antagonist (GnRH-ant) cycles.

Methods: This study was a retrospective cohort study. From October 2017 to April 2022, 412 fertilization (IVF)/intracytoplasmic sperm injection (ICSI) patients who were treated with GnRH-ant protocol for controlled ovarian hyperstimulation (COH) in the reproductive center of our hospital were selected as the research objects.

Trajectory-dependent threshold effects of proton stopping power in LiF nanosheets.

We conducted a study on the trajectory-dependent threshold effects of proton stopping power in LiF nanosheets using time-dependent density functional theory non-adiabatically coupled to the molecular dynamics. This study covered protons with initial velocities in the range of 0.1-1.

Type II diabetes mellitus increases the risk of inflammatory bowel disease in a prospective cohort study.

Background: Inflammatory bowel disease is a common digestive disorder and diabetes can lead to intestinal dysfunction. Patients with inflammatory bowel disease in combination with diabetes present a higher rate of hospitalization and consumption of medical resources, yet the association between type 2 diabetes and Inflammatory bowel disease remains unknown.

Methods: We studied 313,008 participants from the UK Biobank, including 5891 patients with type 2 diabetes at baseline.

Association between pro-inflammatory diet and abdominal pain: cross-sectional and case-control study from UK biobank and NHANES 2017-2020.

Background: There is a close association between diet and abdominal pain; however, relationship between inflammatory diet and characteristics of abdominal pain has not been characterized yet.

Methods: This study analyzed baseline data from the UK Biobank, 3-item DHQ-Abdominal Pain Questionnaire (DHQ-3Q), which including abdominal pain in the past 3 months, severity of abdominal pain, and frequency of abdominal pain, and data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020. Energy-adjusted Dietary Inflammatory Index (E-DII), constructed based on 26 or 27 nutrients, was analyzed using continuous or categorical methods.

Risk analysis of air pollutants and types of anemia: a UK Biobank prospective cohort study.

Previous studies have suggested that exposure to air pollutants may be associated with specific blood indicators or anemia in certain populations. However, there is insufficient epidemiological data and prospective evidence to evaluate the relationship between environmental air pollution and specific types of anemia. We conducted a large-scale prospective cohort study based on the UK Biobank.

The Effectiveness of Artificial Intelligence in Assisting Mothers with Assessing Infant Stool Consistency in a Breastfeeding Cohort Study in China.

Breastfeeding is widely recognized as the gold standard for infant nutrition, benefitting infants' gastrointestinal tracts. Stool analysis helps in understanding pediatric gastrointestinal health, but the effectiveness of automated fecal consistency evaluation by parents of breastfeeding infants has not been investigated. Photographs of one-month-old infants' feces on diapers were taken via a smartphone app and independently categorized by Artificial Intelligence (AI), parents, and researchers.

Predicting the prognosis of glioma patients with TERT promoter mutations and guiding the specific immune profile of immune checkpoint blockade therapy.

The telomerase reverse transcriptase promoter (TERTp) is frequently mutated in gliomas. This study sought to identify immune biomarkers of gliomas with TERTp mutations. Data from TCGA were used to identify and validate survival-associated gene signatures, and immune and stromal scores were calculated using the ESTIMATE algorithm.