Impact of glucagon-like peptide-1 receptor agonists on the incidence of inflammatory bowel disease in people with type 2 diabetes.

Aims: To evaluate the association between the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and the likelihood of developing inflammatory bowel disease (IBD) and medical utilisation in individuals with type 2 diabetes mellitus (T2DM).

Materials And Methods: We used the TriNetX US collaborative network to identify 3 165 521 patients with T2DM from 1 January 2014 to 31 December 2022. Of these, we selected 69 874, 109 922 and 88 079 matched pairs of GLP-1 RA and basal insulin users, dipeptidyl peptidase-4 inhibitor (DPP-4i) and sodium-glucose co-transporter 2 inhibitor (SGLT2i) users, respectively, based on propensity scores.

The Association of HPV Vaccination and Risk of Immune-Mediated Diseases.

Background: Whether prior human papillomavirus vaccination (HPVV) can influence later development of immune-mediated diseases remain controversial. We aim to examine HPVV 's association with various immune-mediated diseases among females aged 9-45 years, considering age, vaccine types, and racial disparities.

Methods: Based on data from the US Collaborative Network in TriNetX spanning from January 1, 2018, to December 20, 2022, we enrolled 208,638 females aged 9-45 years who had received HPVV and matched them with 208,638 individuals who had never received HPVV, using propensity scores.

Diabetic Microvascular Disease and Risk of Peripheral Artery Disease, Foot Ulcer, Leg Infection, and Amputation.

Patients with diabetes are at risk for developing peripheral artery disease, foot ulcer, and amputation. We conducted this study to compare the risk of peripheral artery disease, foot ulcer, and amputation between patients with type 2 diabetes with and without microvascular disease.We identified 1,013,154 patients aged 18 to 80 years and newly diagnosed with type 2 diabetes between January 1, 2008, and December 31, 2018, as the study participants.

Comparative Effectiveness of TNF-α and IL-6 Inhibitors on Bone Health Outcomes and Mortality in Rheumatoid Arthritis Patients: A Retrospective Cohort Study.

Background: Rheumatoid arthritis (RA) significantly impacts bone health, leading to osteoporosis and increased fracture risks. This study aims to compare the effects of TNF-α and IL-6 inhibitors on the incidence of fractures, osteoporosis, and mortality among RA patients.

Methods: We conducted a retrospective cohort study using the TriNetX database, spanning from January 1, 2015, to December 31, 2022.

Varicose vein is associated with an increased risk of ischemic stroke: a population-based matched cohort study.

Importance: The association between varicose veins (VVs) and stroke, and the influence of VV management on the risk of stroke remained unclear.

Objective: To evaluate whether VVs are associated with an elevated risk of stroke and assess if interventions for VVs alter this risk.

Design: From 1 January 2000 to 31 December 2015, adults with VVs were matched by propensity score with those without VVs.

Risk of acute myocardial infarction in patients with non-typhoidal Salmonella infection: A nationwide matched population-based cohort study.

Objectives: We used a nationwide cohort to explore the association of non-typhoidal Salmonella (NTS) with risk of incident acute myocardial infarction (AMI).

Study Design: Nationwide matched population-based cohort study.

Methods: We retrospectively analyzed a national insurance database, in which the NTS cohort (N = 15,152) and non-NTS cohort (N = 60,608) were individually-matched at 1:4 ratio by the index date, age, gender, and propensity score of comorbidities.

Obstructive Sleep Apnea and Risk of Respiratory Syncytial Viral Infection: A Retrospective Multi-Institution Cohort Study.

This retrospective cohort study evaluated the association between obstructive sleep apnea (OSA) and the risk of respiratory syncytial virus (RSV) infection and its complications using data from the TriNetX US Collaborative Database. Patients diagnosed with OSA (n = 1 061 261) and matched controls (n = 3 479 494) were identified via ICD-10-CM codes. Propensity score matching adjusted for 19 covariates to balance baseline characteristics.

Effects of SGLT2 inhibitors on transplant survival and key clinical outcomes in heart transplant recipients with diabetes.

Background: Chronic kidney disease and heart allograft vasculopathy are the primary causes of morbidity and mortality after cardiac transplant. This study aimed to evaluate the impact of sodium-glucose cotransporter-2 inhibitors (SGLT2i) on transplant survival, cardiovascular events, dialysis, and all-cause mortality in diabetes patients who have undergone heart transplantation.

Methods: In this research, we adopted data from the TriNetX collaborative network to observe outcomes in patients who underwent heart transplants between January 01, 2015 and December 31, 2022.

Association between obstructive sleep apnea and migraine: A United States population-based cohort study.

Objective: To determine the association between obstructive sleep apnea (OSA) and the incidence of migraine using a large population-based dataset, as well as to identify the at-risk target groups.

Background: Epidemiological and biochemical studies have provided evidence for the close connection between sleep disorders and migraine. Understanding the connections between OSA and migraine, as well as their shared risk factors, may provide new perspectives on the pathophysiology of both OSA and migraine and novel approaches to managing and treating these conditions.

Risk of SARS-CoV-2 infection and adverse outcomes among vaccinated patients with tuberculosis.

Objectives: Limited data are available to assess breakthrough SARS-CoV-2 infections, medical utilization, and mortality in patients with tuberculosis (TB). The aim of this study was to examine the risk of COVID-19 and severe outcomes in patients with TB between January 2020 and March 2022.

Study Design: US electronic medical records were used to identify TB and non-TB patients who completed the primary series of vaccination and had no prior COVID-19.

Acarbose might be associated with reduced risk of gastric cancer in patients with diabetes mellitus: A nationwide population-based cohort study.

Background: Several epidemiologic studies have revealed a higher risk of cancer in patients with diabetes mellitus (DM) relative to the general population. To investigate whether the use of acarbose was associated with higher/lower risk of new-onset cancers.

Method: We conducted a retrospective cohort study, using a population-based National Health Insurance Research Database of Taiwan.

Risks of Kawasaki disease and multisystem inflammatory syndrome in pediatric patients with COVID-19 infection: A TriNetX based cohort study.

Background: The associations of coronavirus disease (COVID-19) with Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) remain unclear. Few large-scale studies have estimated the cumulative incidence of MIS-C and KD after COVID-19 in children.

Methods: Data were obtained from TriNetX.

Prior COVID-19 vaccination and reduced risk of cerebrovascular diseases among COVID-19 survivors.

The effects of COVID-19 vaccination on short-term and long-term cerebrovascular risks among COVID-19 survivors remained unknown. We conducted a national multi-center retrospective cohort study with 151 597 vaccinated and 151 597 unvaccinated COVID-19 patients using the TriNetX database, from January 1, 2020 to December 31, 2023. Patients baseline characteristics were balanced with propensity score matching (PSM).

Increased Risk of Inflammatory Bowel Disease Among Patients With Nontyphoidal Salmonella Infections: A Population-Based Cohort Study.

Background: Despite the known association between microorganisms and development of inflammatory bowel disease (IBD), the role of nontyphoidal Salmonella (NTS) in IBD is not adequately addressed. We aimed at elucidating the relationship between NTS infection and the risk of IBD.

Methods: Based on the National Health Insurance Research Database in Taiwan, this retrospective cohort study enrolled patients with NTS infection (exposure group; n = 4651) and those without NTS infection (comparator group; n = 4651) who were propensity score matched (1:1) by demographic data, medications, comorbidities, and index date.

Time-dependent risk of atopic dermatitis following nontyphoidal Salmonella infection.

Background: The pathogenesis of atopic dermatitis (AD) remains unclear. Nontyphoidal Salmonella (NTS) infection might trigger immune-mediated reactions. We aimed to examine NTS and the risk of subsequent AD.

Maternal human papillomavirus infection and the risk of congenital malformations: A nationwide population-based cohort study.

Previous research has explored theories regarding the vertical transmission of human papillomavirus (HPV) infection and its association with adverse pregnancy and perinatal outcomes. However, the impact of maternal HPV infection on congenital anomalies (CAs) in offspring remains relatively understudied. We conducted a population-based cohort study linking the Taiwan Birth Registry, Taiwan Death Registry, and National Health Insurance Research Database, in which newborns born in Taiwan between 2009 and 2015 were included.

Association of diverticulitis and potential risk of ischemic stroke: population-based matched cohort study in Taiwan.

Background: Previous studies have suggested relationship between diverticular disease and cardiovascular disease. Since cardiovascular disease and cerebrovascular accident share a lot of pathogenesis, diverticulitis could also be a risk factor for stroke. This study tried to establish epidemiological evidence of the relationship between colon diverticulitis and ischemic stroke.

COVID-19 Vaccination Prior to SARS-CoV-2 Infection Reduced Risk of Subsequent Diabetes Mellitus: A Real-World Investigation Using U.S. Electronic Health Records.

Objective: Previous studies have indicated a bidirectional correlation between diabetes and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, no investigation has comprehensively explored the potential of coronavirus disease 2019 (COVID-19) vaccination to reduce the risk of new-onset diabetes in infected individuals.

Research Design And Methods: In the first of 2 cohorts, we compared the risk of new-onset diabetes between individuals infected with SARS-CoV-2 and noninfected individuals (N = 1,562,606) using the TriNetX database to validate findings in prior literature.

Absence of an association between gastrointestinal tract surgery and newly diagnosed psoriasis: A nationwide, population-based, nested, case-control study.

Background: Gastrointestinal tract surgeries could disrupt the microbiome and simultaneously cause trauma, which may result in psoriasis.

Objective: To examine associations between gastrointestinal tract surgeries and newly diagnosed psoriasis.

Methods: This nested case-control study included patients with newly diagnosed psoriasis from 2005 to 2013, retrieved from the Taiwan National Health Insurance Research Database.

Recent Human Papillomavirus Vaccination is Associated with a Lower Risk of COVID-19: A US Database Cohort Study.

Objective: To explore the association between human papillomavirus (HPV) vaccination and risk of coronavirus disease 2019 (COVID-19). Specifically, our study aimed to test the hypothesis that HPV vaccination may also induce trained immunity, which would potentially reduce the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and improve clinical outcomes.

Background: Several vaccines have been reported to trigger non-specific immune reactions that could offer protection from heterologous infections.