Snhg18 regulates Yap subcellular localization to maintain bone homeostasis.

Osteoporosis treatments commonly mitigate bone loss but rarely restore lost bone mass. Yes-associated protein (Yap) nuclear translocation is crucial for the osteogenic differentiation of bone marrow stromal cells (BMSCs), but is disrupted by many factors under osteoporotic conditions. Long non-coding RNAs (lncRNAs) regulate BMSCs differentiation and Yap localization across diseases, exhibiting tissue- and cell-specific effects.

Hierarchical Nanocellulose-Based Functional Films: A Sustainable and High-Performance Alternative to Conventional Plastic Films.

The rapid increase in plastic production has led to significant environmental challenges due to the accumulation of nondegradable plastic waste, underscoring the urgent need for sustainable alternatives. Nanocellulose, the most abundant renewable biopolymer on Earth, has emerged as a promising candidate for next-generation film materials. This review explores the potential of nanocellulose films as a sustainable replacement for conventional oil-derived plastic films, focusing on its hierarchical structure, tunable properties, and diverse functionalities.

Sword and Board in One: A Bioinspired Nanocomposite Membrane for Guided Bone Regeneration.

Guided bone regeneration (GBR) faces far from a one-dimensional challenge. It demands a multifunctional membrane to possess paradoxical but essential properties in sophisticated clinical scenarios. Drawing inspiration from natural biological structures and superior properties, through a combination of structure innovation and composition regulation, a multicomponent nacre-inspired discontinuous Bouligand structure is devised and transcribed into a bioinspired Janus nanocomposite membrane with comprehensive properties for GBR, identical to "sword and board.

A novel Liesegang-patterned mineralized hydrogel drives bone regeneration with microstructure control.

Bone regeneration remains a critical challenge in modern medicine. Recent advancements have focused on incorporating hierarchical microstructures into biomaterials to enhance osteogenesis. Mineralized hydrogels, while promising, face limitations in precise microstructure control due to technical complexities.

Zfp260 choreographs the early stage osteo-lineage commitment of skeletal stem cells.

The initial fine-tuning processes are crucial for successful bone regeneration, as they guide skeletal stem cells through progenitor differentiation toward osteo- or chondrogenic fate. While fate determination processes are well-documented, the mechanisms preceding progenitor commitment remain poorly understood. Here, we identified a transcription factor, Zfp260, as pivotal for stem cell maturation into progenitors and directing osteogenic differentiation.

Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer.

Therapeutic resistance represents a bottleneck to treatment in advanced gastric cancer (GC). Ferroptosis is an iron-dependent form of non-apoptotic cell death and is associated with anti-cancer therapeutic efficacy. Further investigations are required to clarify the underlying mechanisms.

A Bioinspired Gelatin-Amorphous Calcium Phosphate Coating on Titanium Implant for Bone Regeneration.

Biocompatible and bio-active coatings can enhance and accelerate osseointegration via chemical binding onto substrates. Amorphous calcium phosphate (ACP) has been shown as a precursor to achieve mineralization in vertebrates and invertebrates under the control of biological macromolecules. This work presents a simple bioinspired Gelatin-CaPO (Gel-CaP) composite coating on titanium surfaces to improve osseointegration.

Organized mineralized cellulose nanostructures for biomedical applications.

Cellulose is the most abundant naturally-occurring polymer, and possesses a one-dimensional (1D) anisotropic crystalline nanostructure with outstanding mechanical robustness, biocompatibility, renewability and rich surface chemistry in the form of nanocellulose in nature. Such features make cellulose an ideal bio-template for directing the bio-inspired mineralization of inorganic components into hierarchical nanostructures that are promising in biomedical applications. In this review, we will summarize the chemistry and nanostructure characteristics of cellulose and discuss how these favorable characteristics regulate the bio-inspired mineralization process for manufacturing the desired nanostructured bio-composites.

Amorphous Precursor-Mediated Calcium Phosphate Coatings with Tunable Microstructures for Customized Bone Implants.

Calcium phosphate (CaP) is frequently used as coating for bone implants to promote osseointegration. However, commercial CaP coatings via plasma spraying display similar microstructures, and thus fail to provide specific implants according to different surgical conditions or skeletal bone sites. Herein, inspired by the formation of natural biominerals with various morphologies mediated by amorphous precursors, CaP coatings with tunable microstructures mediated by an amorphous metastable phase are fabricated.

A novel lineage of osteoprogenitor cells with dual epithelial and mesenchymal properties govern maxillofacial bone homeostasis and regeneration after MSFL.

Bone regeneration originates from proliferation and differentiation of osteoprogenitors via either endochondral or intramembranous ossification; and the regeneration capacities decline with age and estrogen loss. Maxillary sinus floor lifting (MSFL) is a commonly used surgical procedure for guiding bone regeneration in maxilla. Radiographic analysis of 1210 clinical cases of maxilla bone regeneration after MSFL revealed that the intrasinus osteogenic efficacy was independent of age and gender, however; and this might be related to the Schneiderian membrane that lines the sinus cavity.

Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment.

Periodontitis is the sixth most prevalent diseases around the globe, which is closely related to many systemic diseases and affects general health. As the leading cause of tooth loss, periodontitis is characterized by irreversible alveolar bone loss and activated osteoclastogenic process, which might be closely related to the activated intracellular reactive oxygen species (ROS) in osteoclasts. Here, we demonstrated triggering receptor expressed on myeloid cells 2 (Trem2) as a key regulator of osteoclastogenesis with the regulation of intracellular ROS signals in periodontitis.

Coronectomy: A Useful Approach in Minimizing Nerve Injury Compared With Traditional Extraction of Deeply Impacted Mandibular Third Molars.

Purpose: A surgical procedure to minimize the incidence of inferior alveolar nerve injury (IANI) in deeply impacted mandibular third molars (IMTMs) has been proposed. Our study compared the near-term outcomes between coronectomy and traditional extraction of IMTMs and evaluated the long-term complications after coronectomy using cone-beam computed tomography (CBCT).

Patients And Methods: A prospective study was performed of patients with IMTMs at high-risk of IANI using radiographic examination and CBCT.

Dual micelles-loaded gelatin nanofibers and their application in lipopolysaccharide-induced periodontal disease.

Introduction: Combined therapies utilizing inhibitors to remove pathogens are needed to suppress lipopolysaccharide (LPS)-induced periodontal disease. We prepared a novel, multi-agent delivery scaffold for periodontal treatment.

Methods: In this study, we synthesized SP600125 (a JNK inhibitor) and SB203580 (a p38 inhibitor) drug-loaded poly(ethylene glycol)-block-caprolactone copolymer via dialysis method.

Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls.

Altered gut microbiota is associated with autism spectrum disorders (ASD), a group of complex, fast growing but difficult-to-diagnose neurodevelopmental disorders worldwide. However, the role of the oral microbiota in ASD remains unexplored. Via high-throughput sequencing of 111 oral samples in 32 children with ASD and 27 healthy controls, we demonstrated that the salivary and dental microbiota of ASD patients were highly distinct from those of healthy individuals.