A Porous MOF Containing Accessible Open Metal Sites with Low Steric Hindrance for Selective Separation of Hydrocarbons.

Conventional hydrocarbon production yields impure products, while solvent-based purification techniques emit volatile pollutants and are energy-intensive. Metal-organic frameworks (MOFs) with open metal sites (OMSs) offer an energy-efficient and eco-friendly alternative, yet steric hindrance from OMSs with traditional geometries restricts multimolecule adsorption. Herein, a stable incorporating novel seesaw-geometry OMSs was constructed using a 1,3,5-tris(pyrazolyl)benzene ligand.

Terpene and lignan glycosides from the leaves of Cyclocarya paliurus and their anti-inflammatory activity.

Nine undescribed glycosides including five terpene glycosides (1-5) and four lignan glycosides (6-9), together with thirteen known compounds, were isolated from the n-BuOH fraction of the leaves of Cyclocarya paliurus. Their structures including absolute configuration were elucidated by extensive spectroscopic analysis and computational methods including NMR and ECD calculations. All isolates were screened for inhibitory effect against LPS-induced nitric oxide production in RAW 264.

Comparisons of Whole Saliva and Cell Free Saliva by DIA-Based Proteome Profiling.

Background: Saliva has emerged as a promising diagnostic resource due to its accessibility, noninvasiveness, and repeatability, enabling early disease detection and timely intervention. However, current studies often overlook the distinction between whole saliva (WS) and cell-free saliva (CFS). Objective This study aims to compare the proteomic profiles of WS and CFS.

Systematic and practical solvent system selection strategy based on the nonrandom two-liquid segment activity coefficient model for real-life counter-current chromatography separation.

Solvent system selection is the first step toward a successful counter-current chromatography (CCC) separation. This paper introduces a systematic and practical solvent system selection strategy based on the nonrandom two-liquid segment activity coefficient (NRTL-SAC) model, which is efficient in predicting the solute partition coefficient. Firstly, the application of the NRTL-SAC method was extended to the ethyl acetate/n-butanol/water and chloroform/methanol/water solvent system families.

Using nonrandom two-liquid model for solvent system selection in counter-current chromatography.

Selection of an appropriate solvent system is of great importance for a successful counter-current chromatography separation. In this work, the nonrandom two-liquid (NRTL) model, a thermodynamic method, was used for predicting the partition coefficient based on a few measured partition coefficients. The NRTL method provides quite satisfactory results for model solutes in first correlating measured partition coefficient in a few representative biphasic liquid systems and then successfully predicting partition coefficient in other two-phase liquid systems.

Separation of nine compounds from Salvia plebeia R.Br. using two-step high-speed counter-current chromatography with different elution modes.

Nine compounds were successfully separated from Salvia plebeia R.Br. using two-step high-speed counter-current chromatography with three elution modes.

Thaxtomin A-deficient endophytic Streptomyces sp. enhances plant disease resistance to pathogenic Streptomyces scabies.

Each plant species in nature harbors endophytes, a community of microbes living within host plants without causing any disease symptom. However, the exploitation of endophyte-based phytoprotectants is hampered by the paucity of mechanistic understandings of endophyte-plant interaction. We here reported two endophytic Streptomyces isolates IFB-A02 and IFB-A03 recovered from a stress-tolerant dicotyledonous plant Artemisia annua L.

Polyphenolic acetylcholinesterase inhibitors from Hopea chinensis.

Bioassay-guided investigation of the stem bark of Hopea chinensis led to the isolation of two new polyphenols, hopeachinols C(1) and D(2), together with ten known compounds (3-12). Compounds 1 and 2 were determined by extensive analysis of spectroscopic data and computational methods. All of these phytochemicals were tested for acetylcholinesterase inhibitory activity, and five resveratrol-derived compounds (1 and 7-10) exhibited significant activity with their IC₅₀ values ranging from 4.

Relative and absolute configuration of vatiparol (1 mg): a novel anti-inflammatory polyphenol.

Bioactive natural products offer multiple opportunities for the discovery of novel chemical entities with potential pharmaceutical, nutraceutical and agrochemical applications. Many new organic compounds with novel scaffolds are isolated in small quantities and established methods often fail to determine the structure and bioactivity of such novel natural products. To meet this challenge, we present here a new methodology combining RDC (residual dipolar coupling)-based NMR spectroscopy in microtubes, with a motif-inspired biological assessment strategy.