Harnessing Biomaterials for Gene Therapy in Autoimmune Disease.

The integration of biomaterials and gene therapy heralds a transformative approach for treating autoimmune diseases, which are characterized by immune dysregulation and chronic inflammation. Conventional therapies often suffer from systemic toxicity and nonspecific immunosuppression, highlighting the need for precision medicine strategies. This review highlights recent breakthroughs in biomaterial-assisted delivery of gene therapy tools, such as small interfering RNA (siRNA), messenger RNA (mRNA), and clustered regularly interspaced short palindromic repeats-CRISPR-associated 9 (CRISPR-Cas9).

Clinical value of serum iPTH, ALP and serum markers levels in patients with secondary hyperparathyroidism receiving paricalcitol combined with cinacalcet.

Background: This study aimed to evaluate the effect of combining paricalcitol with cinacalcet on the levels of intact parathyroid hormone (iPTH) and alkaline phosphatase (ALP) in patients with secondary hyperparathyroidism undergoing maintenance hemodialysis (MHD).

Methods: A retrospective analysis was conducted on the clinical records of 129 patients diagnosed with chronic kidney disease (CKD) and secondary hyperparathyroidism who received MHD between June and December 2022. The patients were categorised into three groups based on their treatment regimen: Group A (paricalcitol alone, n=43), Group B (cinacalcet alone, n=43), and Group C (combined paricalcitol and cinacalcet, n=43).

Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction.

Tissue damage and functional abnormalities in organs have become a considerable clinical challenge. Organoids are often applied as disease models and in drug discovery and screening. Indeed, several studies have shown that organoids are an important strategy for achieving tissue repair and biofunction reconstruction.

The calcium concentration of peritoneal dialysis solution modifies levels of key mediators of peritoneal fibrosis.

Background: To explore the effects of different calcium concentrations of peritoneal dialysis solution (PDS) on continuous ambulatory peritoneal dialysis (CAPD) and expression of vimentin (VIM), fibroblast-specific protein (FSP1), and E-cadherin.

Materials And Methods: This was a pilot study (#ChiCTR1900021387) conducted from January 2017 to December 2019 at the Hospital. The patients were randomized to undergo CAPD using PDS with a calcium concentration of 1.

Impact of twice- or three-times-weekly maintenance hemodialysis on patient outcomes: A multicenter randomized trial.

Aim: Maintenance hemodialysis (MHD) frequency is associated with survival and complication rates. Achieving the optimal balance between healthcare, quality of life (QOL), and medical costs is challenging. We compared complications, inflammatory status, nutritional status, and QOL between patients with different MHD frequencies.