Curcumin alleviated oxidation stress injury by mediating osteopontin in nephrolithiasis rats.

Purpose: To explore the role and mechanism of curcumin (Cur) in reducing oxidative stress damage in rats with nephrolithiasis induced by ethylene glycol (EG).

Methods: Thirty male rats were divided into normal control, model, positive (10% potassium citrate), Cur-10 (10 mg/kg curcumin) and Cur-20 (20 mg/kg curcumin) groups.

Results: The results of kidney tissue section stained by hematoxylin-eosin and von Kossa showed that curcumin treatment can inhibit the formation of kidney stones.

Fractionalization on the Surface: Is Type-II Terminated 1T-TaS_{2} Surface an Anomalously Realized Spin Liquid?

The type-II terminated 1T-TaS_{2} surface of a three-dimensional 1T-TaS_{2} bulk material realizes the effective spin-1/2 degree of freedom on each David star cluster with T^{2}=-1 such that the time-reversal symmetry is realized anomalously, despite the fact that bulk three-dimensional 1T-TaS_{2} material has an even number of electrons per unit cell with T^{2}=+1. This surface is effectively viewed as a spin-1/2 triangular lattice magnet, except with a fully gapped topological bulk. We further propose this surface termination realizes a spinon Fermi surface spin liquid with the surface fractionalization but with a nonexotic three-dimensional bulk.

[Clinical Characteristics and Risk Factors of ESKAPE Pathogens Bloodstream Infection in Cancer Patients].

Objective: To identify the risk factors of ESKAPE pathogens infection and related death in cancer patients, and to supply evidence for clinical precaution and diagnosis.

Methods: A retrospective study of clinical and experimental data of cancer patients with bloodstream infection were carried out in Sichuan Cancer Hospital from 2013 to 2018. The clinical feature, predisposing factors and risk factors of death in ESKAPE group and non-ESKAPE group were analyzed by univariate analysis and multivariate logistic regression.

Ginkgetin induces apoptosis in 786-O cell line suppression of JAK2-STAT3 pathway.

Objectives: Renal cell carcinoma (RCC) is insensitive to conventional chemotherapy. Ginkgetin effectively treats several carcinoma cells. However, little is known about effects of Ginkgetin on RCC.

Cantharidin induces G2/M arrest and triggers apoptosis in renal cell carcinoma.

The present study aimed to investigate the effects of cantharidin on cell cycle distribution, the induction of apoptosis, and Notch1 and Jagged1 expression in ACHN and Caki‑1 renal cancer cells. Cell viability assay, flow cytometry, cell cycle and western blot analyses were performed for ACHN and Caki‑1 cells. Immunohistochemistry was used to analyze the expression of Notch1 and Jagged1 in RCC tissues The results demonstrated that treatment with cantharidin exerted a dose‑ and time‑dependent effect on cell viability, apoptosis induction and G2/M phase cell cycle arrest.

Gastric metaplasia and Helicobacter pylori infection in hemodialysis patients.

Background: Upper gastrointestinal (UGI) symptoms are common in hemodialysis (HD) patients, while gastric metaplasia (GM) and Helicobacter pylori infections are key causes for UGI symptoms. This study is targeted to compare GM and H. pylori infections in patients with different durations of HD.