Encapsulation of nanoparticles with Xe adsorption sites into MOFs for enhanced Xe/Kr separation.

Xenon (Xe) and krypton (Kr) are important gases with significant industrial and medical applications. Metal-organic frameworks (MOFs) are a promising class of sorbent materials for Xe/Kr separation. To enhance the Xe/Kr separation performance of MOFs, we develop a strategy to encapsulate Pt nanoparticles into MOFs to introduce strong Xe adsorption sites.

Bacterial biofilm on peritoneal dialysis catheters: A retrospective observational study.

Biofilm formation significantly impacts infection risks in peritoneal dialysis (PD) patients. However, few studies focused on biofilms on PD catheters. This study aims to explore the formation and characteristics of bacterial biofilm on PD catheters.

A facile two-step synthesis of hollow MOF-74 for enhanced dynamic Xe/Kr separation.

Metal-organic frameworks (MOFs) with high-density uncoordinated open metal sites have been intensively investigated in Xe/Kr separation because of their strong and selective interaction with Xe. However, the dynamic Xe/Kr separation behavior of these MOFs is often unsatisfactory in practical applications due to slow diffusion kinetics. This work presents a facile two-step method to synthesize hollow Ni-MOF-74 particles with short diffusion lengths to enhance dynamic Xe/Kr separation.

Short-term peritoneal rest reduces peritoneal solute transport rate and increases ultrafiltration in high/high average transport peritoneal dialysis patients: a crossover randomized controlled trial.

Background: The peritoneal solute transport rate (PSTR) tends to increase over time in some patients undergoing peritoneal dialysis (PD), potentially leading to ultrafiltration (UF) failure. Previous case reports have shown a significant decrease in PSTR and subsequent recovery of UF after discontinuing PD for a while. Therefore, we conducted a randomized controlled crossover study to evaluate the impact of short-term peritoneal rest on PSTR.

Risk Factors of the Occurrence and Treatment Failure of Refractory Peritoneal Dialysis-Associated Peritonitis: A Single-Center Retrospective Study From China.

Background: This study aimed to investigate the clinical characteristics and prognosis of refractory peritoneal dialysis (PD)-associated peritonitis as well as the risk factors of its occurrence and treatment failure.

Methods: A single-center retrospective cohort study was conducted among 519 patients undergoing PD from January 2007 to October 2021. According to the International Society for Peritoneal Dialysis guidelines, all episodes occurred in our center were divided into two groups: refractory and nonrefractory.

Effect of different dialysis duration on the prognosis of peritoneal dialysis-associated peritonitis: a single-center, retrospective study.

Background: Peritoneal dialysis (PD)-associated peritonitis is a serious complication observed in peritoneal dialysis patients. Herein, we investigated the clinical characteristics and treatment outcomes of PD peritonitis in patients with different PD durations.

Methods: All peritonitis episodes from January 2007 to December 2020 at Peking University People's hospital PD center were retrospectively analyzed and divided into the long-dialysis duration (≥60 months, LDD) and short-dialysis duration (<60 months, SDD) groups.

High Hydrogen Isotope Separation Efficiency: Graphene or Catalyst?

Single-layer graphene has been demonstrated to be a high-efficiency hydrogen isotope sieving membrane in the electrochemical hydrogen pumping system. In this work, we transferred this membrane to proton exchange membrane water electrolysis (PEMWE), which has wide industrial applications. Two membrane electrode assemblies with decorated Pt and ink-coated Pt were investigated.

A microporous Ce-based MOF with the octahedron cage for highly selective adsorption towards xenon over krypton.

The collection of high-purity noble gases with recyclable nuclides provides substantial economic benefits and minimizes the risk of environmental pollution, which is a future development tendency for nuclear industries. Here, Ce-SINAP-1, with its radiation-resistance (up to 20 kGy of γ-ray irradiation) and suitable pore channels for the separation of noble gases (Ar, Kr and Xe), was synthesized. Ce-SINAP-1 exhibited the selective adsorption of Xe (2.

A comparison of coupled microeconomic and mental health devastating alterations between low-income and affluent countries afflicted with COVID-19.

Background: The exponential increase in the rate of individuals' affliction by SARS-CoV-2 (COVID-19) has put extreme strains on health care systems worldwide and has sparked fears of an impending economic recession and mental turmoil.

Objective: The review discusses the impact of COVID-19 on medical crises in two sections, focusing on the evidence presented from both neuropathological and epidemiological perspectives. First, this paper outlines how countries have implemented containment and appraises its effect on the microeconomy.

Enhanced Adsorption and Separation of Xenon over Krypton via an Unsaturated Calcium Center in a Metal-Organic Framework.

Krypton (Kr) and xenon (Xe) are nowadays widely applied in technical and industrial fields. Separating and collecting highly pure Xe from nuclear facilities are necessary and urgent. However, the technology is limited due to the inert nature of Xe and other interferential factors.

Discovery of an Orally Bioavailable Dual PI3K/mTOR Inhibitor Based on Sulfonyl-Substituted Morpholinopyrimidines.

The discovery and optimization of a series of 2-morpholino-pyrimidine derivatives containing various sulfonyl side chains at the C position led to the identification of compound as a potent dual PI3K/mTOR inhibitor. It exhibited high inhibitory activity against PI3Kα/β/γ/δ (IC = 20/376/204/46 nM) and mTOR (IC = 189 nM), potent functional suppression of AKT phosphorylation (IC = 196 nM), and excellent antiproliferative effects on a panel of cancer cells. Enzymic data and modeling simulation indicate that a cyclopropyl ring on the C sulfone chain and a fluorine on the C aminopyridyl moiety are responsible for its maintained PI3K activity and enhanced mTOR potency, respectively.

Hypolipidemic activity and mechanisms of the total phenylpropanoid glycosides from Ligustrum robustum (Roxb.) Blume by AMPK-SREBP-1c pathway in hamsters fed a high-fat diet.

The aim of this study was to evaluate the hypolipidemic effect and mechanisms of total phenylpropanoid glycosides extracted from Ligustrum robustum (Roxb.) Blume (LRTPG) in hamsters fed a high-fat diet and to discover bioactive components in HepG2 cell model induced by oleic acid. LRTPG of high (1.

The Development of Protein Chips for High Throughput Screening (HTS) of Chemically Labeling Small Molecular Drugs.

How to construct protein chips and chemically labeling drug molecules without disrupting structures for HTS is still a challenging area. There are two main obstacles, one is that human multitrans membrane receptors, which are major drug targets, exhibit distinct motifs, and fold structures, and they will collapse unfold without membrane support in vitro; another one is that there still lack effective chemical labeling method for small drugs for detection. Therefore, how to acquire high detecting sensitivity for small molecules and to immobilize membrane protein receptors in native conformation with uniform direction on the chip, need to be solved for drug HTS.

Anti-obesity effect of total phenylpropanoid glycosides from Ligustrum robustum Blume in fatty diet-fed mice via up-regulating leptin.

Ethnopharmacological Relevance: In Chinese folk medicine, the leaves of Ligustrum robustum Blume (LR) were commonly used in the treatment of obesity and hyperlipidemia. This study aimed to evaluate the anti-obesity effect and mechanisms of total phenylpropanoid glycosides from Ligustrum robustum Blume (LRTPG) in fatty diet-fed C57BL/6J mice.

Materials And Methods: C57BL/6J mice were divided randomly into 6 groups, i.